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Fusion gene ID: 13243 |
FusionGeneSummary for FCGRT_PRMT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FCGRT_PRMT1 | Fusion gene ID: 13243 | Hgene | Tgene | Gene symbol | FCGRT | PRMT1 | Gene ID | 2217 | 3276 |
| Gene name | Fc fragment of IgG receptor and transporter | protein arginine methyltransferase 1 | |
| Synonyms | FCRN|alpha-chain | ANM1|HCP1|HRMT1L2|IR1B4 | |
| Cytomap | 19q13.33 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | IgG receptor FcRn large subunit p51Fc fragment of IgG, receptor, transporter, alphaFcRn alpha chainIgG Fc fragment receptor transporter alpha chainheavy chain of the major histocompatibility complex class I-like Fc receptorimmunoglobulin receptor, in | protein arginine N-methyltransferase 1HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2histone-arginine N-methyltransferase PRMT1interferon receptor 1-bound protein 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P55899 | Q99873 | |
| Ensembl transtripts involved in fusion gene | ENST00000221466, ENST00000426395, ENST00000594823, ENST00000599988, ENST00000596975, | ENST00000532489, ENST00000391851, ENST00000454376, ENST00000527866, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: FCGRT [Title/Abstract] AND PRMT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRMT1 | GO:0016571 | histone methylation | 19405910 |
| Tgene | PRMT1 | GO:0018216 | peptidyl-arginine methylation | 18657504|19460357 |
| Tgene | PRMT1 | GO:0043985 | histone H4-R3 methylation | 11448779 |
| Tgene | PRMT1 | GO:0045653 | negative regulation of megakaryocyte differentiation | 20442406 |
| Tgene | PRMT1 | GO:0051260 | protein homooligomerization | 26876602 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-20-1683-01A | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000221466 | ENST00000532489 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 5CDS-5UTR | ENST00000221466 | ENST00000391851 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 5CDS-5UTR | ENST00000221466 | ENST00000454376 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 5CDS-intron | ENST00000221466 | ENST00000527866 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 5CDS-5UTR | ENST00000426395 | ENST00000532489 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 5CDS-5UTR | ENST00000426395 | ENST00000391851 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 5CDS-5UTR | ENST00000426395 | ENST00000454376 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 5CDS-intron | ENST00000426395 | ENST00000527866 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 3UTR-5UTR | ENST00000594823 | ENST00000532489 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 3UTR-5UTR | ENST00000594823 | ENST00000391851 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 3UTR-5UTR | ENST00000594823 | ENST00000454376 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| 3UTR-intron | ENST00000594823 | ENST00000527866 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| intron-5UTR | ENST00000599988 | ENST00000532489 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| intron-5UTR | ENST00000599988 | ENST00000391851 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| intron-5UTR | ENST00000599988 | ENST00000454376 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| intron-intron | ENST00000599988 | ENST00000527866 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| intron-5UTR | ENST00000596975 | ENST00000532489 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| intron-5UTR | ENST00000596975 | ENST00000391851 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| intron-5UTR | ENST00000596975 | ENST00000454376 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
| intron-intron | ENST00000596975 | ENST00000527866 | FCGRT | chr19 | 50017743 | + | PRMT1 | chr19 | 50183744 | + |
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FusionProtFeatures for FCGRT_PRMT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FCGRT | PRMT1 |
| Binds to the Fc region of monomeric immunoglobulinsgamma (PubMed:7964511, PubMed:10933786). Mediates the selectiveuptake of IgG from milk and helps newborn animals to acquirepassive immunity. IgG in the milk is bound at the apical surfaceof the intestinal epithelium. The resultant FcRn-IgG complexes aretranscytosed across the intestinal epithelium and IgG is releasedfrom FcRn into blood or tissue fluids (By similarity). Possiblerole in transfer of immunoglobulin G from mother to fetus(PubMed:7964511). {ECO:0000250|UniProtKB:P13599,ECO:0000269|PubMed:10933786, ECO:0000269|PubMed:7964511}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FCGRT_PRMT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FCGRT_PRMT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FCGRT | ALB, ATG16L1, CD1B, A4GALT, HLA-B, HLA-E, ATP1B4, B2M, THBS1, DUSP9, PRTG, CD1E, SGCE, FGFR4, HGFAC, PCDHGA11, XPO6, PODXL2, PCDH10, PDSS1, GAL, SH3GLB1, KIF14, LDLR, DYNC2H1, C3orf52, FGFR2, TNFSF9, ULBP3, COG6, B4GALT5, TIMELESS, PTPRS, RTN4R, TMEM30B, ULBP2, IQCB1, LRP4, SERPINC1, NCAPD2, EXOC7, C1orf112, SNX3, ANTXR1, MPZL1, APLP2, SLC39A1, SCGB1D1, FGFR1, LRP5, TNPO2, LRP6, FURIN, ITM2B, HBA2, PCDH7, GOLIM4, TNPO3 | PRMT1 | BTG1, SSSCA1, TP53, DHX9, FBL, PRMT1, SUPT5H, IFNAR1, ILF3, KHDRBS1, KHDRBS3, HNRNPK, BTG2, HNRNPA1, NCOA3, NCOA2, NCOA1, ESR1, THRB, AR, CARM1, HNRNPR, ZBTB14, SYNCRIP, CAPRIN1, TAF15, FUS, HNRNPU, CIRBP, ARPC3, S100A8, YLPM1, HABP4, IGSF21, MED31, WDR33, LRIF1, HNRNPUL1, KHDRBS2, NR1I2, TERF1, TERF2, NRIP1, HNF4A, HIST1H4A, MBD2, EIF4A1, YY1, NR1H4, STAT5A, MRE11A, PARP1, EP300, RELA, HIST2H4A, GRIP1, SH3GL1, USF1, CNOT8, HIST4H4, BRCA1, ASH2L, HDAC5, AXIN1, CDC37, ARRB2, RUNX1, HIST1H3A, CUL3, CUL2, CDK2, CAND1, COIL, STAT1, GLTSCR2, MAGOH, EIF4A3, SMURF1, FN1, PRMT8, FGF2, RNF187, EWSR1, FAM9A, OFCC1, SPSB1, SPSB2, VHL, DCAF8, CLK3, GPATCH2L, C17orf53, C20orf196, C4orf17, DCAF16, DAXX, FAM83D, MLST8, GRHL3, CEP162, MECOM, PPARA, SAMD3, SPAG8, TBX6, VPS72, WDFY3, ZMYM5, ZNF451, ACLY, COPS7B, NCL, KPNA2, MCM4, MCM7, CSNK2A2, DGCR8, HUWE1, SPEG, WDYHV1, SHMT2, MOV10, NXF1, CUL7, OBSL1, SUZ12, RPS6KB2, GAR1, NSUN5, CTPS1, KPNA6, SNRNP70, NTRK1, HSF2, BCLAF1, THOC1, RNPS1, FBXO7, CERK, CHTOP, GAN, CRY2, MCM2, UBAP2L, RBM15, SMURF2, CDC25B, TENC1, VIM, DYNLT1, CYLD, DNM1L, TRIM25, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FCGRT_PRMT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FCGRT_PRMT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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