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Fusion gene ID: 13234 |
FusionGeneSummary for FBXW9_PRDX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXW9_PRDX2 | Fusion gene ID: 13234 | Hgene | Tgene | Gene symbol | FBXW9 | PRDX2 | Gene ID | 84261 | 7001 |
| Gene name | F-box and WD repeat domain containing 9 | peroxiredoxin 2 | |
| Synonyms | Fbw9 | HEL-S-2a|NKEF-B|NKEFB|PRP|PRX2|PRXII|PTX1|TDPX1|TPX1|TSA | |
| Cytomap | 19p13.13 | 19p13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/WD repeat-containing protein 9F-box and WD-40 domain protein 9F-box and WD-40 domain-containing protein 9F-box and WD-40 repeat containing protein 9specificity factor for SCF ubiquitin ligase | peroxiredoxin-2epididymis secretory sperm binding protein Li 2anatural killer cell-enhancing factor Bthiol-specific antioxidant 1thioredoxin peroxidase 1thioredoxin-dependent peroxide reductase 1torin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5XUX1 | P32119 | |
| Ensembl transtripts involved in fusion gene | ENST00000544494, ENST00000380339, ENST00000393261, ENST00000587955, | ENST00000334482, ENST00000301522, ENST00000435703, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 4=48 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FBXW9 [Title/Abstract] AND PRDX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRDX2 | GO:0019430 | removal of superoxide radicals | 20978343 |
| Tgene | PRDX2 | GO:0034599 | cellular response to oxidative stress | 20978343 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-26-5136-01B | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000544494 | ENST00000334482 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000544494 | ENST00000301522 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000544494 | ENST00000435703 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000380339 | ENST00000334482 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000380339 | ENST00000301522 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000380339 | ENST00000435703 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000393261 | ENST00000334482 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000393261 | ENST00000301522 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000393261 | ENST00000435703 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000587955 | ENST00000334482 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000587955 | ENST00000301522 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
| 5CDS-5UTR | ENST00000587955 | ENST00000435703 | FBXW9 | chr19 | 12805408 | - | PRDX2 | chr19 | 12912084 | - |
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FusionProtFeatures for FBXW9_PRDX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXW9 | PRDX2 |
| Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. | Thiol-specific peroxidase that catalyzes the reductionof hydrogen peroxide and organic hydroperoxides to water andalcohols, respectively. Plays a role in cell protection againstoxidative stress by detoxifying peroxides and as sensor ofhydrogen peroxide-mediated signaling events. Might participate inthe signaling cascades of growth factors and tumor necrosisfactor-alpha by regulating the intracellular concentrations ofH(2)O(2). {ECO:0000269|PubMed:9497357}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBXW9_PRDX2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBXW9_PRDX2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FBXW9 | COPS6, SKP1, CUL1, COPS5, APP | PRDX2 | UCHL5, PPP2R1A, PPP2R1B, CUL2, CDK2, CUL1, CAND1, APP, A2M, CDC37, ECSIT, EXOC6, IFIT5, MAST1, RNF32, APOE, PSEN1, PRDX1, URM1, PRDX5, SGSH, TPM3P4, UBA3, TIPRL, TMEM9, RIF1, SEC23IP, PRDX6, ATP6V1A, UBE2H, PKM, SOD1, PARK7, CYCS, FN1, VCAM1, ITGA4, RAD52, CD320, BAD, CA4, SAT1, UTY, YWHAZ, PRDX4, COPS5, NLGN3, ESR1, HECW2, CACYBP, IPO11, METTL1, PPP2R5D, PPT1, ANXA2, DUT, MSH6, PCBP1, PDCD6IP, ANXA11, ASS1, BAX, CARKD, CAT, CDK1, DAZAP1, FSCN1, FUBP1, GAPDH, GLOD4, GPX4, HINT1, KHSRP, LAP3, LDHA, NANS, PAICS, PCMT1, PGAM1, PPA1, SPR, TXN, UBE2T, PRDX3, TALDO1, TPI1, ANKRA2, EWSR1, MPP1, RNASEH2A, NES, ANAPC15, FAM134A, MCM2, OTUB1, U2AF2, COL14A1, RGAG1, KCTD5, MAK, CYLD, DLD, DNM1L, HSD17B10, FOXA1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBXW9_PRDX2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXW9_PRDX2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PRDX2 | C0003949 | Asbestosis | 1 | CTD_human |
| Tgene | PRDX2 | C0013080 | Down Syndrome | 1 | CTD_human |
| Tgene | PRDX2 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Tgene | PRDX2 | C0022548 | Keloid | 1 | CTD_human |
| Tgene | PRDX2 | C0023470 | Myeloid Leukemia | 1 | CTD_human |
| Tgene | PRDX2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | PRDX2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | PRDX2 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | PRDX2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | PRDX2 | C0029463 | Osteosarcoma | 1 | CTD_human |
| Tgene | PRDX2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | PRDX2 | C2239176 | Liver carcinoma | 1 | CTD_human |
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