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Fusion gene ID: 13219 |
FusionGeneSummary for FBXW5_PSMB10 |
Fusion gene summary |
Fusion gene information | Fusion gene name: FBXW5_PSMB10 | Fusion gene ID: 13219 | Hgene | Tgene | Gene symbol | FBXW5 | PSMB10 | Gene ID | 54461 | 5699 |
Gene name | F-box and WD repeat domain containing 5 | proteasome subunit beta 10 | |
Synonyms | Fbw5 | LMP10|MECL1|beta2i | |
Cytomap | 9q34.3 | 16q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | F-box/WD repeat-containing protein 5F-box and WD-40 domain-containing protein 5WD repeat-containing F-box protein FBW5 | proteasome subunit beta type-10low molecular mass protein 10macropain subunit MECl-1multicatalytic endopeptidase complex subunit MECl-1proteasome (prosome, macropain) subunit, beta type, 10proteasome MECl-1proteasome catalytic subunit 2iproteasome | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q969U6 | P40306 | |
Ensembl transtripts involved in fusion gene | ENST00000325285, ENST00000483559, | ENST00000358514, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: FBXW5 [Title/Abstract] AND PSMB10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FBXW5 | GO:0016567 | protein ubiquitination | 18381890|21725316 |
Hgene | FBXW5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 21725316 |
Hgene | FBXW5 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 18381890 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE832990 | FBXW5 | chr9 | 139835187 | + | PSMB10 | chr16 | 67970383 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000325285 | ENST00000358514 | FBXW5 | chr9 | 139835187 | + | PSMB10 | chr16 | 67970383 | - |
intron-3CDS | ENST00000483559 | ENST00000358514 | FBXW5 | chr9 | 139835187 | + | PSMB10 | chr16 | 67970383 | - |
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FusionProtFeatures for FBXW5_PSMB10 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FBXW5 | PSMB10 |
The proteasome is a multicatalytic proteinase complexwhich is characterized by its ability to cleave peptides with Arg,Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral orslightly basic pH. The proteasome has an ATP-dependent proteolyticactivity. This subunit is involved in antigen processing togenerate class I binding peptides. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBXW5_PSMB10 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBXW5_PSMB10 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBXW5_PSMB10 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PSMB10 | P40306 | DB08889 | Carfilzomib | Proteasome subunit beta type-10 | small molecule | approved|investigational |
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RelatedDiseases for FBXW5_PSMB10 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PSMB10 | C0019693 | HIV Infections | 1 | CTD_human |
Tgene | PSMB10 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |