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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13219

FusionGeneSummary for FBXW5_PSMB10

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXW5_PSMB10
Fusion gene ID: 13219
HgeneTgene
Gene symbol

FBXW5

PSMB10

Gene ID

54461

5699

Gene nameF-box and WD repeat domain containing 5proteasome subunit beta 10
SynonymsFbw5LMP10|MECL1|beta2i
Cytomap

9q34.3

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 5F-box and WD-40 domain-containing protein 5WD repeat-containing F-box protein FBW5proteasome subunit beta type-10low molecular mass protein 10macropain subunit MECl-1multicatalytic endopeptidase complex subunit MECl-1proteasome (prosome, macropain) subunit, beta type, 10proteasome MECl-1proteasome catalytic subunit 2iproteasome
Modification date2018052220180523
UniProtAcc

Q969U6

P40306

Ensembl transtripts involved in fusion geneENST00000325285, ENST00000483559, 
ENST00000358514, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: FBXW5 [Title/Abstract] AND PSMB10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXW5

GO:0016567

protein ubiquitination

18381890|21725316

HgeneFBXW5

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

21725316

HgeneFBXW5

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

18381890


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE832990FBXW5chr9

139835187

+PSMB10chr16

67970383

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000325285ENST00000358514FBXW5chr9

139835187

+PSMB10chr16

67970383

-
intron-3CDSENST00000483559ENST00000358514FBXW5chr9

139835187

+PSMB10chr16

67970383

-

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FusionProtFeatures for FBXW5_PSMB10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXW5

Q969U6

PSMB10

P40306

The proteasome is a multicatalytic proteinase complexwhich is characterized by its ability to cleave peptides with Arg,Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral orslightly basic pH. The proteasome has an ATP-dependent proteolyticactivity. This subunit is involved in antigen processing togenerate class I binding peptides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXW5_PSMB10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXW5_PSMB10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXW5_PSMB10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePSMB10P40306DB08889CarfilzomibProteasome subunit beta type-10small moleculeapproved|investigational

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RelatedDiseases for FBXW5_PSMB10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePSMB10C0019693HIV Infections1CTD_human
TgenePSMB10C0023893Liver Cirrhosis, Experimental1CTD_human