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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13214

FusionGeneSummary for FBXW4_ANKRD44

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXW4_ANKRD44
Fusion gene ID: 13214
HgeneTgene
Gene symbol

FBXW4

ANKRD44

Gene ID

6468

91526

Gene nameF-box and WD repeat domain containing 4ankyrin repeat domain 44
SynonymsDAC|FBW4|FBWD4|SHFM3|SHSF3PP6-ARS-B
Cytomap

10q24.32

2q33.1

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 4F-box and WD-40 domain protein 4F-box and WD-40 domain-containing protein 4F-box/WD repeat protein 4dactylinserine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit Bankyrin repeat domain-containing protein 44protein phosphatase 6 ankyrin repeat subunit Bserine/threonine-protein phosphatase 6 regulatory subunit ARS-B
Modification date2018052320180519
UniProtAcc

P57775

Q8N8A2

Ensembl transtripts involved in fusion geneENST00000331272, ENST00000470093, 
ENST00000282272, ENST00000337207, 
ENST00000450567, ENST00000328737, 
ENST00000409153, ENST00000539527, 
ENST00000409919, ENST00000477852, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 3 X 2=18
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FBXW4 [Title/Abstract] AND ANKRD44 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA640671FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000331272ENST00000282272FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000331272ENST00000337207FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000331272ENST00000450567FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000331272ENST00000328737FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000331272ENST00000409153FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000331272ENST00000539527FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000331272ENST00000409919FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000331272ENST00000477852FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000470093ENST00000282272FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000470093ENST00000337207FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000470093ENST00000450567FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000470093ENST00000328737FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000470093ENST00000409153FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000470093ENST00000539527FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000470093ENST00000409919FBXW4chr10

103411583

+ANKRD44chr2

197969512

+
intron-intronENST00000470093ENST00000477852FBXW4chr10

103411583

+ANKRD44chr2

197969512

+

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FusionProtFeatures for FBXW4_ANKRD44


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXW4

P57775

ANKRD44

Q8N8A2

Probably recognizes and binds to some phosphorylatedproteins and promotes their ubiquitination and degradation. Likelyto be involved in key signaling pathways crucial for normal limbdevelopment. May participate in Wnt signaling. Putative regulatory subunit of protein phosphatase 6(PP6) that may be involved in the recognition of phosphoproteinsubstrates.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXW4_ANKRD44


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXW4_ANKRD44


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXW4_ANKRD44


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXW4_ANKRD44


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource