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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13195

FusionGeneSummary for FBXO7_CCT8

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO7_CCT8
Fusion gene ID: 13195
HgeneTgene
Gene symbol

FBXO7

CCT8

Gene ID

25793

10694

Gene nameF-box protein 7chaperonin containing TCP1 subunit 8
SynonymsFBX|FBX07|FBX7|PARK15|PKPSC21orf112|Cctq|D21S246|PRED71
Cytomap

22q12.3

21q21.3

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 7T-complex protein 1 subunit thetaCCT-thetaTCP-1-thetachaperonin containing T-complex polypeptide 1 subunit 8chaperonin containing TCP1, subunit 8 (theta)renal carcinoma antigen NY-REN-15
Modification date2018052320180523
UniProtAcc

Q9Y3I1

P50990

Ensembl transtripts involved in fusion geneENST00000266087, ENST00000382058, 
ENST00000397426, ENST00000465418, 
ENST00000470450, ENST00000286788, 
ENST00000542732, ENST00000540844, 
Fusion gene scores* DoF score4 X 5 X 2=402 X 2 X 2=8
# samples 52
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: FBXO7 [Title/Abstract] AND CCT8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXO7

GO:0006511

ubiquitin-dependent protein catabolic process

25029497

HgeneFBXO7

GO:0016567

protein ubiquitination

16510124

HgeneFBXO7

GO:0031647

regulation of protein stability

15145941

HgeneFBXO7

GO:0040012

regulation of locomotion

26310625

HgeneFBXO7

GO:1903599

positive regulation of autophagy of mitochondrion

26310625


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG991440FBXO7chr22

32888763

-CCT8chr21

30433614

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000266087ENST00000470450FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000266087ENST00000286788FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000266087ENST00000542732FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000266087ENST00000540844FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000382058ENST00000470450FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000382058ENST00000286788FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000382058ENST00000542732FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000382058ENST00000540844FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000397426ENST00000470450FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000397426ENST00000286788FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000397426ENST00000542732FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000397426ENST00000540844FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000465418ENST00000470450FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000465418ENST00000286788FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000465418ENST00000542732FBXO7chr22

32888763

-CCT8chr21

30433614

-
intron-5UTRENST00000465418ENST00000540844FBXO7chr22

32888763

-CCT8chr21

30433614

-

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FusionProtFeatures for FBXO7_CCT8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO7

Q9Y3I1

CCT8

P50990

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation oftarget proteins. Recognizes BIRC2 and DLGAP5. Plays a roledownstream of PINK1 in the clearance of damaged mitochondria viaselective autophagy (mitophagy) by targeting PRKN to dysfunctionaldepolarized mitochondria. Promotes MFN1 ubiquitination.{ECO:0000269|PubMed:15145941, ECO:0000269|PubMed:16510124,ECO:0000269|PubMed:23933751}. Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXO7_CCT8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXO7_CCT8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXO7_CCT8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXO7_CCT8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBXO7C1850100PARKINSON DISEASE 15, AUTOSOMAL RECESSIVE (disorder)2CTD_human;ORPHANET;UNIPROT