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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13191

FusionGeneSummary for FBXO46_LGALS4

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO46_LGALS4
Fusion gene ID: 13191
HgeneTgene
Gene symbol

FBXO46

LGALS4

Gene ID

23403

3960

Gene nameF-box protein 46galectin 4
Synonyms20D7-FC4|FBXO34L|Fbx46GAL4|L36LBP
Cytomap

19q13.32

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 46galectin-4L-36 lactose-binding proteinantigen NY-CO-27gal-4lactose-binding lectin 4lectin, galactoside-binding, soluble, 4
Modification date2018051920180519
UniProtAcc

Q6PJ61

P56470

Ensembl transtripts involved in fusion geneENST00000317683, ENST00000307751, 
ENST00000597803, 
Fusion gene scores* DoF score4 X 1 X 4=165 X 4 X 4=80
# samples 45
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO46 [Title/Abstract] AND LGALS4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A8PE-01AFBXO46chr19

46234107

-LGALS4chr19

39297235

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000317683ENST00000307751FBXO46chr19

46234107

-LGALS4chr19

39297235

-
5UTR-5UTRENST00000317683ENST00000597803FBXO46chr19

46234107

-LGALS4chr19

39297235

-

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FusionProtFeatures for FBXO46_LGALS4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO46

Q6PJ61

LGALS4

P56470

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. Galectin that binds lactose and a related range ofsugars. May be involved in the assembly of adherens junctions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXO46_LGALS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXO46_LGALS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBXO46SKP1, COPS5, TCP1, SLC25A11, DHX9, RUVBL1, DDX5, HNRNPR, MCM4, CUL1, FSD1, LRFN4, CAPZA2, MYO1C, MYO19, MYO18A, EMILIN1, SDC1, SLC25A41, NEXN, TRIM25LGALS4ARPC3, RRAS2, MLH1, CFTR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXO46_LGALS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXO46_LGALS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource