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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13189

FusionGeneSummary for FBXO44_MTSS1L

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO44_MTSS1L
Fusion gene ID: 13189
HgeneTgene
Gene symbol

FBXO44

MTSS1L

Gene ID

93611

92154

Gene nameF-box protein 44MTSS1L, I-BAR domain containing
SynonymsFBG3|FBX30|FBX6A|Fbx44|Fbxo6aABBA|ABBA-1|ABBA1
Cytomap

1p36.22

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 44F-box gene 3F-box protein FBX30F-box/G-domain protein 3MTSS1-like proteinactin-bundling with BAIAP2 homology protein 1metastasis suppressor 1-like
Modification date2018051920180519
UniProtAcc

Q9H4M3

Q765P7

Ensembl transtripts involved in fusion geneENST00000251546, ENST00000376770, 
ENST00000376768, ENST00000251547, 
ENST00000376760, ENST00000376762, 
ENST00000338779, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO44 [Title/Abstract] AND MTSS1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXO44

GO:0010498

proteasomal protein catabolic process

25970626

TgeneMTSS1L

GO:0036120

cellular response to platelet-derived growth factor stimulus

20875796

TgeneMTSS1L

GO:0090630

activation of GTPase activity

20875796


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF822200FBXO44chr1

11716072

+MTSS1Lchr16

70698524

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000251546ENST00000338779FBXO44chr1

11716072

+MTSS1Lchr16

70698524

-
Frame-shiftENST00000376770ENST00000338779FBXO44chr1

11716072

+MTSS1Lchr16

70698524

-
Frame-shiftENST00000376768ENST00000338779FBXO44chr1

11716072

+MTSS1Lchr16

70698524

-
Frame-shiftENST00000251547ENST00000338779FBXO44chr1

11716072

+MTSS1Lchr16

70698524

-
Frame-shiftENST00000376760ENST00000338779FBXO44chr1

11716072

+MTSS1Lchr16

70698524

-
Frame-shiftENST00000376762ENST00000338779FBXO44chr1

11716072

+MTSS1Lchr16

70698524

-

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FusionProtFeatures for FBXO44_MTSS1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO44

Q9H4M3

MTSS1L

Q765P7

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia infibroblasts, acting via RAC1 activation (PubMed:14752106). Mayfunction in actin bundling (PubMed:14752106).{ECO:0000269|PubMed:14752106}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXO44_MTSS1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXO44_MTSS1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXO44_MTSS1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXO44_MTSS1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBXO44C0032460Polycystic Ovary Syndrome1CTD_human
HgeneFBXO44C0033578Prostatic Neoplasms1CTD_human