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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13176

FusionGeneSummary for FBXO38_FBXO38

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO38_FBXO38
Fusion gene ID: 13176
HgeneTgene
Gene symbol

FBXO38

FBXO38

Gene ID

81545

81545

Gene nameF-box protein 38F-box protein 38
SynonymsFbx38|HMN2D|MOKA|SP329Fbx38|HMN2D|MOKA|SP329
Cytomap

5q32

5q32

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 38modulator of KLF7 activity homologF-box only protein 38modulator of KLF7 activity homolog
Modification date2018051920180519
UniProtAcc

Q6PIJ6

Q6PIJ6

Ensembl transtripts involved in fusion geneENST00000340253, ENST00000296701, 
ENST00000394370, ENST00000509699, 
ENST00000513826, 		ENST00000340253, 
ENST00000296701, ENST00000394370, 
ENST00000509699, ENST00000513826, 
Fusion gene scores* DoF score5 X 5 X 3=753 X 3 X 3=27
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FBXO38 [Title/Abstract] AND FBXO38 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA811966FBXO38chr5

147809152

+FBXO38chr5

147763520

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000340253ENST00000340253FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000340253ENST00000296701FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000340253ENST00000394370FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000340253ENST00000509699FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000340253ENST00000513826FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-5UTRENST00000296701ENST00000340253FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000296701ENST00000296701FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000296701ENST00000394370FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000296701ENST00000509699FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000296701ENST00000513826FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-5UTRENST00000394370ENST00000340253FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000394370ENST00000296701FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000394370ENST00000394370FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000394370ENST00000509699FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000394370ENST00000513826FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-5UTRENST00000509699ENST00000340253FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000509699ENST00000296701FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000509699ENST00000394370FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000509699ENST00000509699FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000509699ENST00000513826FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-5UTRENST00000513826ENST00000340253FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000513826ENST00000296701FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000513826ENST00000394370FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000513826ENST00000509699FBXO38chr5

147809152

+FBXO38chr5

147763520

+
intron-intronENST00000513826ENST00000513826FBXO38chr5

147809152

+FBXO38chr5

147763520

+

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FusionProtFeatures for FBXO38_FBXO38


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO38

Q6PIJ6

FBXO38

Q6PIJ6

Probably recognizes and binds to some phosphorylatedproteins and promotes their ubiquitination and degradation. Maycoactivate KLF7, but does not seem to promote KLF7 ubiquitination(By similarity). {ECO:0000250}. Probably recognizes and binds to some phosphorylatedproteins and promotes their ubiquitination and degradation. Maycoactivate KLF7, but does not seem to promote KLF7 ubiquitination(By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXO38_FBXO38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXO38_FBXO38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXO38_FBXO38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXO38_FBXO38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBXO38C3888271NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IID1UNIPROT
TgeneFBXO38C3888271NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IID1UNIPROT