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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13173

FusionGeneSummary for FBXO36_ALCAM

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO36_ALCAM
Fusion gene ID: 13173
HgeneTgene
Gene symbol

FBXO36

ALCAM

Gene ID

130888

214

Gene nameF-box protein 36activated leukocyte cell adhesion molecule
SynonymsFbx36CD166|MEMD
Cytomap

2q36.3

3q13.11

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 36CD166 antigen
Modification date2018051920180519
UniProtAcc

Q8NEA4

Q13740

Ensembl transtripts involved in fusion geneENST00000373652, ENST00000283946, 
ENST00000409992, 
ENST00000306107, 
ENST00000472644, ENST00000481337, 
ENST00000486979, ENST00000389927, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 4=100
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO36 [Title/Abstract] AND ALCAM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1552-01AFBXO36chr2

230787322

+ALCAMchr3

105290693

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000373652ENST00000306107FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5UTR-3CDSENST00000373652ENST00000472644FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5UTR-intronENST00000373652ENST00000481337FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5UTR-intronENST00000373652ENST00000486979FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5UTR-intronENST00000373652ENST00000389927FBXO36chr2

230787322

+ALCAMchr3

105290693

+
Frame-shiftENST00000283946ENST00000306107FBXO36chr2

230787322

+ALCAMchr3

105290693

+
Frame-shiftENST00000283946ENST00000472644FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5CDS-intronENST00000283946ENST00000481337FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5CDS-intronENST00000283946ENST00000486979FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5CDS-intronENST00000283946ENST00000389927FBXO36chr2

230787322

+ALCAMchr3

105290693

+
Frame-shiftENST00000409992ENST00000306107FBXO36chr2

230787322

+ALCAMchr3

105290693

+
Frame-shiftENST00000409992ENST00000472644FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5CDS-intronENST00000409992ENST00000481337FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5CDS-intronENST00000409992ENST00000486979FBXO36chr2

230787322

+ALCAMchr3

105290693

+
5CDS-intronENST00000409992ENST00000389927FBXO36chr2

230787322

+ALCAMchr3

105290693

+

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FusionProtFeatures for FBXO36_ALCAM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO36

Q8NEA4

ALCAM

Q13740

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. Cell adhesion molecule that mediates both heterotypiccell-cell contacts via its interaction with CD6, as well ashomotypic cell-cell contacts (PubMed:7760007, PubMed:15496415,PubMed:15048703, PubMed:16352806, PubMed:23169771,PubMed:24945728). Promotes T-cell activation and proliferation viaits interactions with CD6 (PubMed:15048703, PubMed:16352806,PubMed:24945728). Contributes to the formation and maturation ofthe immunological synapse via its interactions with CD6(PubMed:15294938, PubMed:16352806). Mediates homotypicinteractions with cells that express ALCAM (PubMed:15496415,PubMed:16352806). Required for normal hematopoietic stem cellengraftment in the bone marrow (PubMed:24740813). Mediatesattachment of dendritic cells onto endothelial cells via homotypicinteraction (PubMed:23169771). Inhibits endothelial cell migrationand promotes endothelial tube formation via homotypic interactions(PubMed:15496415, PubMed:23169771). Required for normalorganization of the lymph vessel network. Required for normalhematopoietic stem cell engraftment in the bone marrow. Plays arole in hematopoiesis; required for normal numbers ofhematopoietic stem cells in bone marrow. Promotes in vitroosteoblast proliferation and differentiation (By similarity).Promotes neurite extension, axon growth and axon guidance; axonsgrow preferentially on surfaces that contain ALCAM. Mediatesoutgrowth and pathfinding for retinal ganglion cell axons (Bysimilarity). {ECO:0000250|UniProtKB:P42292,ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938,ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806,ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}. Isoform 3: Inhibits activities of membrane-boundisoforms by competing for the same interaction partners. Inhibitscell attachment via homotypic interactions. Promotes endothelialcell migration. Inhibits endothelial cell tube formation.{ECO:0000269|PubMed:15496415}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXO36_ALCAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXO36_ALCAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBXO36KRAS, SKP1ALCAMCD6, ART3, EGFR, LGALS3, LGALS8, LGALS9, NTRK1, CDC73, LGALS1, PCDH12, APOD, FBXO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXO36_ALCAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXO36_ALCAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneALCAMC0024667Animal Mammary Neoplasms1CTD_human
TgeneALCAMC0024668Mammary Neoplasms, Experimental1CTD_human