FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13162

FusionGeneSummary for FBXO32_MYEOV

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO32_MYEOV
Fusion gene ID: 13162
HgeneTgene
Gene symbol

FBXO32

MYEOV

Gene ID

114907

26579

Gene nameF-box protein 32myeloma overexpressed
SynonymsFbx32|MAFbxOCIM
Cytomap

8q24.13

11q13.3

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 32atrogin 1muscle atrophy F-box proteinmyeloma-overexpressed gene proteinmyeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas)oncogene in multiple myeloma
Modification date2018051920180519
UniProtAcc

Q969P5

Q96EZ4

Ensembl transtripts involved in fusion geneENST00000517956, ENST00000443022, 
ENST00000441339, ENST00000308946, 
ENST00000535407, ENST00000541137, 
Fusion gene scores* DoF score4 X 6 X 3=7213 X 4 X 7=364
# samples 714
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/364*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO32 [Title/Abstract] AND MYEOV [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXO32

GO:0016567

protein ubiquitination

26753747


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF828660FBXO32chr8

124515477

-MYEOVchr11

69155834

+
ChiTaRS3.1BF828657FBXO32chr8

124515477

-MYEOVchr11

69155834

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000517956ENST00000441339FBXO32chr8

124515477

-MYEOVchr11

69155834

+
intron-intronENST00000517956ENST00000308946FBXO32chr8

124515477

-MYEOVchr11

69155834

+
intron-intronENST00000517956ENST00000535407FBXO32chr8

124515477

-MYEOVchr11

69155834

+
intron-intronENST00000517956ENST00000541137FBXO32chr8

124515477

-MYEOVchr11

69155834

+
intron-intronENST00000443022ENST00000441339FBXO32chr8

124515477

-MYEOVchr11

69155834

+
intron-intronENST00000443022ENST00000308946FBXO32chr8

124515477

-MYEOVchr11

69155834

+
intron-intronENST00000443022ENST00000535407FBXO32chr8

124515477

-MYEOVchr11

69155834

+
intron-intronENST00000443022ENST00000541137FBXO32chr8

124515477

-MYEOVchr11

69155834

+

Top

FusionProtFeatures for FBXO32_MYEOV


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO32

Q969P5

MYEOV

Q96EZ4

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediatesthe ubiquitination and subsequent proteasomal degradation oftarget proteins. Probably recognizes and binds to phosphorylatedtarget proteins during skeletal muscle atrophy. Recognizes TERF1.{ECO:0000269|PubMed:15531760}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FBXO32_MYEOV


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FBXO32_MYEOV


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FBXO32_MYEOV


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FBXO32_MYEOV


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBXO32C0026846Muscular Atrophy1CTD_human