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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13155

FusionGeneSummary for FBXO28_LYZL2

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO28_LYZL2
Fusion gene ID: 13155
HgeneTgene
Gene symbol

FBXO28

LYZL2

Gene ID

23219

119180

Gene nameF-box protein 28lysozyme like 2
SynonymsCENP-30|Fbx28LYZD2
Cytomap

1q42.11

10p11.23

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 28centromere protein 30lysozyme-like protein 2lysozyme D2lysozyme-2
Modification date2018052220180523
UniProtAcc

Q9NVF7

Q7Z4W2

Ensembl transtripts involved in fusion geneENST00000366862, ENST00000424254, 
ENST00000375318, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: FBXO28 [Title/Abstract] AND LYZL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-7406-01AFBXO28chr1

224302098

+LYZL2chr10

30901829

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000366862ENST00000375318FBXO28chr1

224302098

+LYZL2chr10

30901829

-
Frame-shitENST00000424254ENST00000375318FBXO28chr1

224302098

+LYZL2chr10

30901829

-

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FusionProtFeatures for FBXO28_LYZL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO28

Q9NVF7

LYZL2

Q7Z4W2

Probably recognizes and binds to some phosphorylatedproteins and promotes their ubiquitination and degradation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXO28_LYZL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXO28_LYZL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBXO28TRAF2, PSMB1, HSP90AA1, LYN, GK, PAK1, GOLGA2, SKP1, SPAG5, SDCBP2, PLEKHF2, ZWINT, EGFL8, LURAP1L, HOMER1, NUP50, DCTN2, CLEC11A, PSMC3, PAK2, SMEK1, NLRP3, NEDD1, LDHD, MCM2, TRAF1, EML1, ARHGEF6, ARHGEF7, TMCC3, TCP10L, SH3KBP1, PMF1, EML4, GIT2, GIT1, NUPL1, EMILIN1, TRAF7, TRAF5, ANGPTL3, RAB11FIP4, ANGPT2, CCDC89, PFDN4, PTRF, CKAP4, POC1B, IKBIP, TEX28, C15orf27, LRRCC1, SUN1, NCKIPSD, GOPCLYZL2GALNT18, ENTPD5, LOXL2, B4GALNT4, COL6A2, FKBP14, SULF1, VWDE, PCYOX1L, TMEM67, FIGNL1, GAS6, NPTX1, EDEM1, ERO1LB, ASPH, TTC17, NLGN2, COL14A1, SEPN1, CERCAM, CRELD2, CNTNAP3, LAMB2, LRP11, TMTC3, GALNS, RSPRY1, HECTD3, ITGAV, DNAJB9, FSTL1, OS9, MAN2A2, LAMB1, ARSG, TXNDC16, C1QL4, GLB1L, NAGLU, FKBP7, IGF1R, CHST10, PROS1, ADAM9, ZZEF1, MGAT5, MAN2A1, MRC2, MANBA, TUBA4A, POGLUT1, HSP90B1, HSPA5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXO28_LYZL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXO28_LYZL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource