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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13152

FusionGeneSummary for FBXO24_RBFOX2

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXO24_RBFOX2
Fusion gene ID: 13152
HgeneTgene
Gene symbol

FBXO24

RBFOX2

Gene ID

26261

23543

Gene nameF-box protein 24RNA binding fox-1 homolog 2
SynonymsFBX24FOX2|Fox-2|HNRBP2|HRNBP2|RBM9|RTA|dJ106I20.3|fxh
Cytomap

7q22.1

22q12.3

Type of geneprotein-codingprotein-coding
DescriptionF-box only protein 24F-box protein Fbx24RNA binding protein fox-1 homolog 2RNA binding protein, fox-1 homolog 2RNA-binding motif protein 9fox-1 homolog Bfox-1 homologuehexaribonucleotide-binding protein 2repressor of tamoxifen transcriptional activity
Modification date2018051920180523
UniProtAcc

O75426

O43251

Ensembl transtripts involved in fusion geneENST00000498195, ENST00000241071, 
ENST00000360609, ENST00000465843, 
ENST00000468962, ENST00000427939, 
ENST00000405409, ENST00000414461, 
ENST00000449924, ENST00000262829, 
ENST00000397303, ENST00000359369, 
ENST00000416721, ENST00000438146, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 9 X 4=324
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXO24 [Title/Abstract] AND RBFOX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRBFOX2

GO:0030520

intracellular estrogen receptor signaling pathway

11875103

TgeneRBFOX2

GO:0045892

negative regulation of transcription, DNA-templated

11875103


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF753854FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000498195ENST00000405409FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000498195ENST00000414461FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000498195ENST00000449924FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000498195ENST00000262829FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000498195ENST00000397303FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000498195ENST00000359369FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000498195ENST00000416721FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000498195ENST00000438146FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000241071ENST00000405409FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000241071ENST00000414461FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000241071ENST00000449924FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000241071ENST00000262829FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000241071ENST00000397303FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000241071ENST00000359369FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000241071ENST00000416721FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000241071ENST00000438146FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000360609ENST00000405409FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000360609ENST00000414461FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000360609ENST00000449924FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000360609ENST00000262829FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000360609ENST00000397303FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000360609ENST00000359369FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000360609ENST00000416721FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000360609ENST00000438146FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000465843ENST00000405409FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000465843ENST00000414461FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000465843ENST00000449924FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000465843ENST00000262829FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000465843ENST00000397303FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000465843ENST00000359369FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000465843ENST00000416721FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000465843ENST00000438146FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000468962ENST00000405409FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000468962ENST00000414461FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000468962ENST00000449924FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000468962ENST00000262829FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000468962ENST00000397303FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000468962ENST00000359369FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000468962ENST00000416721FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000468962ENST00000438146FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000427939ENST00000405409FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000427939ENST00000414461FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000427939ENST00000449924FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000427939ENST00000262829FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000427939ENST00000397303FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000427939ENST00000359369FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000427939ENST00000416721FBXO24chr7

100193132

-RBFOX2chr22

36205969

-
intron-3CDSENST00000427939ENST00000438146FBXO24chr7

100193132

-RBFOX2chr22

36205969

-

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FusionProtFeatures for FBXO24_RBFOX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXO24

O75426

RBFOX2

O43251

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBXO24_RBFOX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXO24_RBFOX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBXO24_RBFOX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBXO24_RBFOX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRBFOX2C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneRBFOX2C0036095Salivary Gland Neoplasms1CTD_human