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Fusion gene ID: 13117 |
FusionGeneSummary for FBXL2_KIF9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXL2_KIF9 | Fusion gene ID: 13117 | Hgene | Tgene | Gene symbol | FBXL2 | KIF9 | Gene ID | 25827 | 64147 |
| Gene name | F-box and leucine rich repeat protein 2 | kinesin family member 9 | |
| Synonyms | FBL2|FBL3 | - | |
| Cytomap | 3p22.3 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/LRR-repeat protein 2F-box protein FBL2/FBL3F-box protein containing leucine-rich repeats | kinesin-like protein KIF9kinesin protein 9 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UKC9 | Q9HAQ2 | |
| Ensembl transtripts involved in fusion gene | ENST00000484457, ENST00000538892, ENST00000283627, ENST00000538181, ENST00000446237, ENST00000507198, ENST00000542085, | ENST00000335044, ENST00000265529, ENST00000444589, ENST00000452770, ENST00000352910, ENST00000487440, ENST00000425853, ENST00000432493, ENST00000425452, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 3 X 4 X 5=60 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FBXL2 [Title/Abstract] AND KIF9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FBXL2 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 23604317 |
| Hgene | FBXL2 | GO:0016567 | protein ubiquitination | 23604317 |
| Hgene | FBXL2 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 23604317 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-UY-A9PE-01A | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000484457 | ENST00000335044 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000484457 | ENST00000265529 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000484457 | ENST00000444589 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000484457 | ENST00000452770 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000484457 | ENST00000352910 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-5UTR | ENST00000484457 | ENST00000487440 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000484457 | ENST00000425853 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000484457 | ENST00000432493 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000484457 | ENST00000425452 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000538892 | ENST00000335044 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000538892 | ENST00000265529 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000538892 | ENST00000444589 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000538892 | ENST00000452770 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000538892 | ENST00000352910 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-5UTR | ENST00000538892 | ENST00000487440 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000538892 | ENST00000425853 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000538892 | ENST00000432493 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000538892 | ENST00000425452 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000283627 | ENST00000335044 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000283627 | ENST00000265529 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000283627 | ENST00000444589 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000283627 | ENST00000452770 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000283627 | ENST00000352910 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-5UTR | ENST00000283627 | ENST00000487440 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000283627 | ENST00000425853 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000283627 | ENST00000432493 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000283627 | ENST00000425452 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| Frame-shift | ENST00000538181 | ENST00000335044 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| Frame-shift | ENST00000538181 | ENST00000265529 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| Frame-shift | ENST00000538181 | ENST00000444589 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| Frame-shift | ENST00000538181 | ENST00000452770 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| Frame-shift | ENST00000538181 | ENST00000352910 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5CDS-5UTR | ENST00000538181 | ENST00000487440 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5CDS-intron | ENST00000538181 | ENST00000425853 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5CDS-intron | ENST00000538181 | ENST00000432493 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5CDS-intron | ENST00000538181 | ENST00000425452 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000446237 | ENST00000335044 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000446237 | ENST00000265529 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000446237 | ENST00000444589 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000446237 | ENST00000452770 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000446237 | ENST00000352910 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-5UTR | ENST00000446237 | ENST00000487440 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-intron | ENST00000446237 | ENST00000425853 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-intron | ENST00000446237 | ENST00000432493 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-intron | ENST00000446237 | ENST00000425452 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000507198 | ENST00000335044 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000507198 | ENST00000265529 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000507198 | ENST00000444589 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000507198 | ENST00000452770 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-3CDS | ENST00000507198 | ENST00000352910 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-5UTR | ENST00000507198 | ENST00000487440 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000507198 | ENST00000425853 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000507198 | ENST00000432493 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| intron-intron | ENST00000507198 | ENST00000425452 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000542085 | ENST00000335044 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000542085 | ENST00000265529 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000542085 | ENST00000444589 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000542085 | ENST00000452770 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-3CDS | ENST00000542085 | ENST00000352910 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-5UTR | ENST00000542085 | ENST00000487440 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-intron | ENST00000542085 | ENST00000425853 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-intron | ENST00000542085 | ENST00000432493 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
| 5UTR-intron | ENST00000542085 | ENST00000425452 | FBXL2 | chr3 | 33339454 | + | KIF9 | chr3 | 47299050 | - |
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FusionProtFeatures for FBXL2_KIF9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXL2 | KIF9 |
| Calcium-activated substrate recognition component of theSCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligasecomplex, SCF(FBXL2), which mediates the ubiquitination andsubsequent proteasomal degradation of target proteins. Unlike manyF-box proteins, FBXL2 does not seem to target phosphodegron withinits substrates but rather calmodulin-binding motifs and is therebyantagonized by calmodulin. This is the case for the cyclins CCND2and CCND3 which polyubiquitination and subsequent degradation areinhibited by calmodulin. Through CCND2 and CCND3 degradationinduces cell-cycle arrest in G(0) (PubMed:22020328,PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitinationand proteasomal degradation thereby regulatingphosphatidylinositol 3-kinase signaling and autophagy(PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) andsubsequent degradation regulates synthesis of phosphatidylcholine,which is utilized for formation of membranes and of pulmonarysurfactant (By similarity). {ECO:0000250|UniProtKB:Q8BH16,ECO:0000269|PubMed:22020328, ECO:0000269|PubMed:22323446,ECO:0000269|PubMed:23604317}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FBXL2_KIF9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FBXL2_KIF9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FBXL2 | SKP1, CUL1, APP, CCND2, AURKB, HSP90AA1, PIK3R1, PIK3R2, CUL2, CDC34, UBE2D3, PTPN13, RABGGTB, NLRP3, UBE2D1, UBE2G1, FOXM1, YPEL3, YPEL1, ITPR3, VCP, FBXO3 | KIF9 | PRMT6, TRIM37, TRIM27, JAKMIP2, IKZF1, ROPN1, CARD9, EFHC2, LZTS2, SSX2IP, KRTAP10-9, KRTAP10-3, ZBTB8A, FAM188A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FBXL2_KIF9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXL2_KIF9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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