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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1311

FusionGeneSummary for AKAP13_C3orf58

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP13_C3orf58
Fusion gene ID: 1311
HgeneTgene
Gene symbol

AKAP13

C3orf58

Gene ID

11214

205428

Gene nameA-kinase anchoring protein 13chromosome 3 open reading frame 58
SynonymsAKAP-13|AKAP-Lbc|ARHGEF13|BRX|HA-3|Ht31|LBC|PRKA13|PROTO-LB|PROTO-LBC|c-lbc|p47DIA1|GoPro49|HASF
Cytomap

15q25.3

3q24

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 13A kinase (PRKA) anchor protein 13LBC oncogenebreast cancer nuclear receptor-binding auxiliary proteinguanine nucleotide exchange factor Lbchuman thyroid-anchoring protein 31lymphoid blast crisis oncogenenon-oncogenic Rho Gdeleted in autism protein 1Golgi Protein of 49 kDaGolgi protein GoPro49UPF0672 protein C3orf58deleted in autism 1hypoxia and AKT-induced stem cell factorhypoxia and Akt induced stem cell factor
Modification date2018052220180523
UniProtAcc

Q12802

Q8NDZ4

Ensembl transtripts involved in fusion geneENST00000560302, ENST00000394518, 
ENST00000361243, ENST00000560579, 
ENST00000394510, 		ENST00000315691, 
ENST00000493396, ENST00000495414, 
ENST00000441925, 
Fusion gene scores* DoF score21 X 16 X 12=40321 X 1 X 1=1
# samples 221
** MAII scorelog2(22/4032*10)=-4.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: AKAP13 [Title/Abstract] AND C3orf58 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP13

GO:0007186

G-protein coupled receptor signaling pathway

11546812

HgeneAKAP13

GO:0035025

positive regulation of Rho protein signal transduction

11546812

TgeneC3orf58

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

23784961

TgeneC3orf58

GO:0060038

cardiac muscle cell proliferation

23784961


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF127481AKAP13chr15

86288841

+C3orf58chr3

143710481

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000560302ENST00000315691AKAP13chr15

86288841

+C3orf58chr3

143710481

-
intron-intronENST00000560302ENST00000493396AKAP13chr15

86288841

+C3orf58chr3

143710481

-
intron-intronENST00000560302ENST00000495414AKAP13chr15

86288841

+C3orf58chr3

143710481

-
intron-3UTRENST00000560302ENST00000441925AKAP13chr15

86288841

+C3orf58chr3

143710481

-
3UTR-3UTRENST00000394518ENST00000315691AKAP13chr15

86288841

+C3orf58chr3

143710481

-
3UTR-intronENST00000394518ENST00000493396AKAP13chr15

86288841

+C3orf58chr3

143710481

-
3UTR-intronENST00000394518ENST00000495414AKAP13chr15

86288841

+C3orf58chr3

143710481

-
3UTR-3UTRENST00000394518ENST00000441925AKAP13chr15

86288841

+C3orf58chr3

143710481

-
5CDS-3UTRENST00000361243ENST00000315691AKAP13chr15

86288841

+C3orf58chr3

143710481

-
5CDS-intronENST00000361243ENST00000493396AKAP13chr15

86288841

+C3orf58chr3

143710481

-
5CDS-intronENST00000361243ENST00000495414AKAP13chr15

86288841

+C3orf58chr3

143710481

-
5CDS-3UTRENST00000361243ENST00000441925AKAP13chr15

86288841

+C3orf58chr3

143710481

-
intron-3UTRENST00000560579ENST00000315691AKAP13chr15

86288841

+C3orf58chr3

143710481

-
intron-intronENST00000560579ENST00000493396AKAP13chr15

86288841

+C3orf58chr3

143710481

-
intron-intronENST00000560579ENST00000495414AKAP13chr15

86288841

+C3orf58chr3

143710481

-
intron-3UTRENST00000560579ENST00000441925AKAP13chr15

86288841

+C3orf58chr3

143710481

-
3UTR-3UTRENST00000394510ENST00000315691AKAP13chr15

86288841

+C3orf58chr3

143710481

-
3UTR-intronENST00000394510ENST00000493396AKAP13chr15

86288841

+C3orf58chr3

143710481

-
3UTR-intronENST00000394510ENST00000495414AKAP13chr15

86288841

+C3orf58chr3

143710481

-
3UTR-3UTRENST00000394510ENST00000441925AKAP13chr15

86288841

+C3orf58chr3

143710481

-

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FusionProtFeatures for AKAP13_C3orf58


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP13

Q12802

C3orf58

Q8NDZ4

May play a role in cardiomyocyte proliferation throughparacrine signaling and activation of the PPI3K-AKT-CDK7 signalingcascade. {ECO:0000269|PubMed:23784961}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AKAP13_C3orf58


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AKAP13_C3orf58


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AKAP13_C3orf58


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AKAP13_C3orf58


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP13C0007134Renal Cell Carcinoma1CTD_human
HgeneAKAP13C0014859Esophageal Neoplasms1CTD_human
TgeneC3orf58C0004352Autistic Disorder1CTD_human
TgeneC3orf58C1510586Autism Spectrum Disorders1CTD_human