	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 13103

FusionGeneSummary for FBXL20_SNHG14

Fusion gene summary

Fusion gene information	Fusion gene name: FBXL20_SNHG14
	Fusion gene ID: 13103
		Hgene	Tgene
	Gene symbol	FBXL20	SNHG14
	Gene ID	84961	104472715
	Gene name	F-box and leucine rich repeat protein 20	small nucleolar RNA host gene 14
	Synonyms	Fbl2\|Fbl20	115HG\|IC-SNURF-SNRPN\|LNCAT\|NCRNA00214\|U-UBE3A-ATS\|UBE3A-AS\|UBE3A-AS1\|UBE3AATS
	Cytomap	17q12	15q11.2
	Type of gene	protein-coding	ncRNA
	Description	F-box/LRR-repeat protein 20F-box protein FBL2	UBE3A antisense RNA 1 (non-protein coding)UBE3A antisense transcriptlarge noncoding antisense transcriptsmall nucleolar RNA host gene 14 (non-protein coding)
	Modification date	20180523	20180329
	UniProtAcc	Q96IG2
	Ensembl transtripts involved in fusion gene	ENST00000583610, ENST00000394294, ENST00000264658, ENST00000577399,	ENST00000549804, ENST00000547292, ENST00000424208, ENST00000452731, ENST00000554726, ENST00000551631, ENST00000459433, ENST00000551361, ENST00000553134, ENST00000551938, ENST00000384733, ENST00000551077, ENST00000546682, ENST00000553108, ENST00000384430, ENST00000516123, ENST00000553149, ENST00000441592, ENST00000365306, ENST00000414175, ENST00000456576, ENST00000363358, ENST00000424333, ENST00000450809, ENST00000453082, ENST00000365067, ENST00000390982, ENST00000580438,
Fusion gene scores	* DoF score	40 X 12 X 14=6720	3 X 3 X 2=18
	# samples	38	3
	** MAII score	log2(38/6720*10)=-4.14438990933518 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FBXL20 [Title/Abstract] AND SNHG14 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-UL-AAZ6-01A	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000583610	ENST00000549804	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000547292	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-3UTR	ENST00000583610	ENST00000424208	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000452731	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000554726	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000551631	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000459433	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000551361	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000553134	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000551938	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000384733	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000551077	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000546682	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000553108	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000384430	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000516123	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000553149	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000441592	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000365306	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000414175	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000456576	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000363358	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000424333	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000450809	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-3UTR	ENST00000583610	ENST00000453082	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000365067	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000390982	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000583610	ENST00000580438	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000549804	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000547292	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-3UTR	ENST00000394294	ENST00000424208	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000452731	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000554726	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000551631	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000459433	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000551361	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000553134	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000551938	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000384733	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000551077	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000546682	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000553108	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000384430	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000516123	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000553149	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000441592	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000365306	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000414175	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000456576	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000363358	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000424333	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000450809	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-3UTR	ENST00000394294	ENST00000453082	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000365067	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000390982	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000394294	ENST00000580438	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000549804	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000547292	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-3UTR	ENST00000264658	ENST00000424208	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000452731	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000554726	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000551631	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000459433	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000551361	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000553134	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000551938	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000384733	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000551077	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000546682	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000553108	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000384430	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000516123	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000553149	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000441592	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000365306	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000414175	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000456576	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000363358	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000424333	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000450809	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-3UTR	ENST00000264658	ENST00000453082	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000365067	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000390982	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
intron-intron	ENST00000264658	ENST00000580438	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000549804	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000547292	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-3UTR	ENST00000577399	ENST00000424208	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000452731	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000554726	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000551631	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000459433	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000551361	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000553134	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000551938	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000384733	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000551077	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000546682	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000553108	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000384430	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000516123	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000553149	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000441592	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000365306	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000414175	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000456576	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000363358	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000424333	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000450809	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-3UTR	ENST00000577399	ENST00000453082	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000365067	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000390982	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+
5CDS-intron	ENST00000577399	ENST00000580438	FBXL20	chr17	37558426	-	SNHG14	chr15	25467306	+

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FusionProtFeatures for FBXL20_SNHG14

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FBXL20 Q96IG2	SNHG14
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neuraltransmission (By similarity). {ECO:0000250}.	Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269\|PubMed:10224141, ECO:0000269\|PubMed:28301481}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for FBXL20_SNHG14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBXL20_SNHG14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
FBXL20	CUL1, KRAS, YPEL3, PVR, YPEL1, RABGGTB	SNHG14

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for FBXL20_SNHG14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FBXL20_SNHG14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 13103

FusionGeneSummary for FBXL20_SNHG14

FusionProtFeatures for FBXL20_SNHG14

FusionGeneSequence for FBXL20_SNHG14

FusionGenePPI for FBXL20_SNHG14

RelatedDrugs for FBXL20_SNHG14

RelatedDiseases for FBXL20_SNHG14