FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 131

FusionGeneSummary for ABCB8_ABCB8

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCB8_ABCB8
Fusion gene ID: 131
HgeneTgene
Gene symbol

ABCB8

ABCB8

Gene ID

11194

11194

Gene nameATP binding cassette subfamily B member 8ATP binding cassette subfamily B member 8
SynonymsEST328128|M-ABC1|MABC1EST328128|M-ABC1|MABC1
Cytomap

7q36.1

7q36.1

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family B member 8, mitochondrialATP-binding cassette, sub-family B (MDR/TAP), member 8mitochondrial ABC proteinmitochondrial ATP-binding cassette 1ATP-binding cassette sub-family B member 8, mitochondrialATP-binding cassette, sub-family B (MDR/TAP), member 8mitochondrial ABC proteinmitochondrial ATP-binding cassette 1
Modification date2018052320180523
UniProtAcc

Q9NUT2

Q9NUT2

Ensembl transtripts involved in fusion geneENST00000358849, ENST00000542328, 
ENST00000297504, ENST00000356058, 
ENST00000498578, ENST00000477719, 
ENST00000477092, ENST00000493338, 
ENST00000358849, ENST00000542328, 
ENST00000297504, ENST00000356058, 
ENST00000498578, ENST00000477719, 
ENST00000477092, ENST00000493338, 
Fusion gene scores* DoF score2 X 2 X 3=123 X 3 X 3=27
# samples 33
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ABCB8 [Title/Abstract] AND ABCB8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP369304ABCB8chr7

150742435

+ABCB8chr7

150730827

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000358849ENST00000358849ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000358849ENST00000542328ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000358849ENST00000297504ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000358849ENST00000356058ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000358849ENST00000498578ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000358849ENST00000477719ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000358849ENST00000477092ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-3UTRENST00000358849ENST00000493338ABCB8chr7

150742435

+ABCB8chr7

150730827

+
Frame-shiftENST00000542328ENST00000358849ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000542328ENST00000542328ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000542328ENST00000297504ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000542328ENST00000356058ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000542328ENST00000498578ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000542328ENST00000477719ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000542328ENST00000477092ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-3UTRENST00000542328ENST00000493338ABCB8chr7

150742435

+ABCB8chr7

150730827

+
Frame-shiftENST00000297504ENST00000358849ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000297504ENST00000542328ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000297504ENST00000297504ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000297504ENST00000356058ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000297504ENST00000498578ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000297504ENST00000477719ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000297504ENST00000477092ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-3UTRENST00000297504ENST00000493338ABCB8chr7

150742435

+ABCB8chr7

150730827

+
3UTR-3CDSENST00000356058ENST00000358849ABCB8chr7

150742435

+ABCB8chr7

150730827

+
3UTR-intronENST00000356058ENST00000542328ABCB8chr7

150742435

+ABCB8chr7

150730827

+
3UTR-intronENST00000356058ENST00000297504ABCB8chr7

150742435

+ABCB8chr7

150730827

+
3UTR-intronENST00000356058ENST00000356058ABCB8chr7

150742435

+ABCB8chr7

150730827

+
3UTR-intronENST00000356058ENST00000498578ABCB8chr7

150742435

+ABCB8chr7

150730827

+
3UTR-intronENST00000356058ENST00000477719ABCB8chr7

150742435

+ABCB8chr7

150730827

+
3UTR-intronENST00000356058ENST00000477092ABCB8chr7

150742435

+ABCB8chr7

150730827

+
3UTR-3UTRENST00000356058ENST00000493338ABCB8chr7

150742435

+ABCB8chr7

150730827

+
Frame-shiftENST00000498578ENST00000358849ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000498578ENST00000542328ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000498578ENST00000297504ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000498578ENST00000356058ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000498578ENST00000498578ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000498578ENST00000477719ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-intronENST00000498578ENST00000477092ABCB8chr7

150742435

+ABCB8chr7

150730827

+
5CDS-3UTRENST00000498578ENST00000493338ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-3CDSENST00000477719ENST00000358849ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477719ENST00000542328ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477719ENST00000297504ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477719ENST00000356058ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477719ENST00000498578ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477719ENST00000477719ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477719ENST00000477092ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-3UTRENST00000477719ENST00000493338ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-3CDSENST00000477092ENST00000358849ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477092ENST00000542328ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477092ENST00000297504ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477092ENST00000356058ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477092ENST00000498578ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477092ENST00000477719ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000477092ENST00000477092ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-3UTRENST00000477092ENST00000493338ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-3CDSENST00000493338ENST00000358849ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000493338ENST00000542328ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000493338ENST00000297504ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000493338ENST00000356058ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000493338ENST00000498578ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000493338ENST00000477719ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-intronENST00000493338ENST00000477092ABCB8chr7

150742435

+ABCB8chr7

150730827

+
intron-3UTRENST00000493338ENST00000493338ABCB8chr7

150742435

+ABCB8chr7

150730827

+

Top

FusionProtFeatures for ABCB8_ABCB8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCB8

Q9NUT2

ABCB8

Q9NUT2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ABCB8_ABCB8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ABCB8_ABCB8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ABCB8_ABCB8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ABCB8_ABCB8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource