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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13014

FusionGeneSummary for FBLN1_CDK19

check button Fusion gene summary
Fusion gene informationFusion gene name: FBLN1_CDK19
Fusion gene ID: 13014
HgeneTgene
Gene symbol

FBLN1

CDK19

Gene ID

2192

23097

Gene namefibulin 1cyclin dependent kinase 19
SynonymsFBLN|FIBL1CDC2L6|CDK11|bA346C16.3
Cytomap

22q13.31

6q21

Type of geneprotein-codingprotein-coding
Descriptionfibulin-1cyclin-dependent kinase 19CDC2-related protein kinase 6CDK8-like cyclin-dependent kinasecell division cycle 2-like 6 (CDK8-like)cell division cycle 2-like protein kinase 6cell division protein kinase 19cyclin dependent kinase 19 variant 2cyclin-dep
Modification date2018052220180523
UniProtAcc

P23142

Q9BWU1

Ensembl transtripts involved in fusion geneENST00000348697, ENST00000402984, 
ENST00000262722, ENST00000327858, 
ENST00000442170, ENST00000340923, 
ENST00000476366, 
ENST00000368911, 
ENST00000323817, ENST00000413605, 
ENST00000497709, 
Fusion gene scores* DoF score8 X 9 X 5=36010 X 9 X 5=450
# samples 1012
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/450*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBLN1 [Title/Abstract] AND CDK19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBLN1

GO:0001933

negative regulation of protein phosphorylation

11792823

HgeneFBLN1

GO:0007162

negative regulation of cell adhesion

11792823

HgeneFBLN1

GO:0007229

integrin-mediated signaling pathway

11792823

HgeneFBLN1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11792823

HgeneFBLN1

GO:0072378

blood coagulation, fibrin clot formation

7642629

HgeneFBLN1

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

11792823

HgeneFBLN1

GO:2000146

negative regulation of cell motility

11792823

HgeneFBLN1

GO:2000647

negative regulation of stem cell proliferation

11238726


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A1L4-01AFBLN1chr22

45914667

+CDK19chr6

111095140

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000348697ENST00000368911FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-5UTRENST00000348697ENST00000323817FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000348697ENST00000413605FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000348697ENST00000497709FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000402984ENST00000368911FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-5UTRENST00000402984ENST00000323817FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000402984ENST00000413605FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000402984ENST00000497709FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000262722ENST00000368911FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-5UTRENST00000262722ENST00000323817FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000262722ENST00000413605FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000262722ENST00000497709FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000327858ENST00000368911FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-5UTRENST00000327858ENST00000323817FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000327858ENST00000413605FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000327858ENST00000497709FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000442170ENST00000368911FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-5UTRENST00000442170ENST00000323817FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000442170ENST00000413605FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000442170ENST00000497709FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000340923ENST00000368911FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-5UTRENST00000340923ENST00000323817FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000340923ENST00000413605FBLN1chr22

45914667

+CDK19chr6

111095140

-
5CDS-intronENST00000340923ENST00000497709FBLN1chr22

45914667

+CDK19chr6

111095140

-
intron-intronENST00000476366ENST00000368911FBLN1chr22

45914667

+CDK19chr6

111095140

-
intron-5UTRENST00000476366ENST00000323817FBLN1chr22

45914667

+CDK19chr6

111095140

-
intron-intronENST00000476366ENST00000413605FBLN1chr22

45914667

+CDK19chr6

111095140

-
intron-intronENST00000476366ENST00000497709FBLN1chr22

45914667

+CDK19chr6

111095140

-

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FusionProtFeatures for FBLN1_CDK19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBLN1

P23142

CDK19

Q9BWU1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FBLN1_CDK19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FBLN1_CDK19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBLN1MPG, APP, NID1, ELN, FBLN1, FGB, FN1, NOV, CTGF, CACNA1A, ATN1, GFI1B, SKIL, SMAD4, TCF7L2, ADAMTSL4, TAF9, SMAD3, NOTCH3, PLSCR1, TDGF1, LTBP4, TANK, YWHAQ, NEDD1, APOA1, BHLHE40, ADAMTSL2, EDC4, DKK1, LGALS9, FCN1, PLSCR4, SFRP4, KCTD9, PTPRK, PSG1, PSG3, WNT4, ZFP41, IFI30, NLGN3, DDIAS, OCLN, DEFA1, COLQ, WNT7A, IRF9, PAK7, EFEMP1, ZNF517, NELL1, FAM19A3, PLA2G10, CCDC89, TYW3, AGRP, TRIM25, MCPH1CDK19MYCBPAP, RB1CC1, MED10, MED9, MED29, MED19, MED28, MED26, SRSF7, MED12, MED1, ZC3H13, SMARCA4, BCL6, SUZ12, MED18, MED16, FKBP15, GNAQ, MYEF2, COMMD4, NIFK, CTCF, GPN1, CUTA, RNPC3, APOD, ERC1, MED13, MED14, MED17, MED13L, MED4, MED15, CLU, MED6, MED24, MED8, CCNC, MED23, MED27, MED20, AZGP1, MED31, MED22, PIP, MED11, MED30, MED7, MASP1, FAM49B, MRPS31, CDK8, MED12L, PRMT5, STK38, WDR77, MED21, LZIC, BIRC8, IGFBP6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FBLN1_CDK19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FBLN1_CDK19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBLN1C0014175Endometriosis1CTD_human
HgeneFBLN1C0033578Prostatic Neoplasms1CTD_human