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Fusion gene ID: 1301 |
FusionGeneSummary for AKAP10_GID4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKAP10_GID4 | Fusion gene ID: 1301 | Hgene | Tgene | Gene symbol | AKAP10 | GID4 | Gene ID | 11216 | 79018 |
| Gene name | A-kinase anchoring protein 10 | GID complex subunit 4 homolog | |
| Synonyms | AKAP-10|D-AKAP-2|D-AKAP2|PRKA10 | C17orf39|VID2|VID24 | |
| Cytomap | 17p11.2 | 17p11.2|17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A-kinase anchor protein 10, mitochondrialA kinase (PRKA) anchor protein 10A kinase anchor protein 10dual specificity A kinase-anchoring protein 2mitochondrial A kinase PPKA anchor protein 10protein kinase A anchoring protein 10 | glucose-induced degradation protein 4 homologGID complex subunit 4, VID24 homologvacuolar import and degradation 24vacuolar import and degradation protein 24 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43572 | Q8IVV7 | |
| Ensembl transtripts involved in fusion gene | ENST00000225737, ENST00000395536, ENST00000572155, | ENST00000268719, ENST00000376345, ENST00000579871, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 3 X 4=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AKAP10 [Title/Abstract] AND GID4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-YL-A9WY-01A | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000225737 | ENST00000268719 | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
| 5CDS-intron | ENST00000225737 | ENST00000376345 | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
| 5CDS-intron | ENST00000225737 | ENST00000579871 | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
| In-frame | ENST00000395536 | ENST00000268719 | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
| 5CDS-intron | ENST00000395536 | ENST00000376345 | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
| 5CDS-intron | ENST00000395536 | ENST00000579871 | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
| intron-3CDS | ENST00000572155 | ENST00000268719 | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
| intron-intron | ENST00000572155 | ENST00000376345 | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
| intron-intron | ENST00000572155 | ENST00000579871 | AKAP10 | chr17 | 19839599 | - | GID4 | chr17 | 17962182 | + |
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FusionProtFeatures for AKAP10_GID4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKAP10 | GID4 |
| Differentially targeted protein that binds to type I andII regulatory subunits of protein kinase A and anchors them to themitochondria or the plasma membrane. Although the physiologicalrelevance between PKA and AKAPS with mitochondria is not fullyunderstood, one idea is that BAD, a proapoptotic member, isphosphorylated and inactivated by mitochondria-anchored PKA. Itcannot be excluded too that it may facilitate PKA as well as Gprotein signal transduction, by acting as an adapter forassembling multiprotein complexes. With its RGS domain, it couldlead to the interaction to G-alpha proteins, providing a linkbetween the signaling machinery and the downstream kinase (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AKAP10 | chr17:19839599 | chr17:17962182 | ENST00000225737 | - | 9 | 15 | 125_369 | 489 | 663 | Domain | RGS 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >AKAP10 | chr17:19839599 | chr17:17962182 | ENST00000225737 | - | 9 | 15 | 379_505 | 489 | 663 | Domain | RGS 2 |
| Hgene | >AKAP10 | chr17:19839599 | chr17:17962182 | ENST00000225737 | - | 9 | 15 | 634_647 | 489 | 663 | Region | Note=PKA-RII subunit binding |
| Tgene | GID4 | chr17:19839599 | chr17:17962182 | ENST00000268719 | + | 2 | 6 | 42_109 | 202 | 301 | Compositional bias | Note=Pro-rich |
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FusionGeneSequence for AKAP10_GID4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AKAP10_ENST00000225737_chr17_19839599_-_GID4_ENST00000268719_chr17_17962182_+_588aa MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTAT LKKQPSHMEAAHFGDLGRSCLDYQTQETKSSLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQECDSAHSLRLEMARAGTHQVSMETQESSST LTVASRNSPASPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHP LGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKGKFLAFYQYAKSFNSDDFDYEELKNGDYVFMRWKEQFLVPDHTIKDISGAS >In-frame_AKAP10_ENST00000395536_chr17_19839599_-_GID4_ENST00000268719_chr17_17962182_+_588aa MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTAT LKKQPSHMEAAHFGDLGRSCLDYQTQETKSSLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQECDSAHSLRLEMARAGTHQVSMETQESSST LTVASRNSPASPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHP LGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKGKFLAFYQYAKSFNSDDFDYEELKNGDYVFMRWKEQFLVPDHTIKDISGAS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AKAP10_ENST00000225737_chr17_19839599_-_GID4_ENST00000268719_chr17_17962182_+_1764nt ATGAGGGGAGCCGGGCCCTCCCCGCGCCAGTCCCCCCGCACCCTCCGTCCCGACCCGGGCCCCGCCATGTCCTTCTTCCGGCGGAAAGTG AAAGGCAAAGAACAAGAGAAGACCTCAGATGTGAAGTCCATTAAAGCTTCAATATCCGTACATTCCCCACAAAAAAGCACTAAAAATCAT GCCTTGCTGGAGGCTGCAGGACCAAGTCATGTTGCAATCAATGCCATTTCTGCCAACATGGACTCCTTTTCAAGTAGCAGGACAGCCACA CTTAAGAAGCAGCCAAGCCACATGGAGGCCGCTCATTTTGGTGACCTGGGCAGATCTTGTCTGGACTACCAGACTCAAGAGACCAAATCA AGCCTTTCTAAGACCCTTGAACAAGTCTTGCACGACACTATTGTCCTCCCTTACTTCATTCAATTCATGGAACTTCGGCGAATGGAGCAT TTGGTGAAATTTTGGTTAGAGGCTGAAAGTTTTCATTCAACAACTTGGTCGCGAATAAGAGCACACAGTCTAAACACAGTGAAGCAGAGC TCACTGGCTGAGCCTGTCTCTCCATCTAAAAAGCATGAAACTACAGCGTCTTTTTTAACTGATTCTCTTGATAAGAGATTGGAGGATTCT GGCTCAGCACAGTTGTTTATGACTCATTCAGAAGGAATTGACCTGAATAATAGAACTAACAGCACTCAGAATCACTTGCTGCTTTCCCAG GAATGTGACAGTGCCCATTCTCTCCGTCTTGAAATGGCCAGAGCAGGAACTCACCAAGTTTCCATGGAAACCCAAGAATCTTCCTCTACA CTTACAGTAGCCAGTAGAAATAGTCCCGCTTCTCCACTAAAAGAATTGTCAGGAAAACTAATGAAAAGTATAGAACAAGATGCAGTGAAT ACTTTTACCAAATATATATCTCCAGATGCTGCTAAACCAATACCAATTACAGAAGCAATGAGAAATGACATCATAGCAAGGATTTGTGGA GAAGATGGACAGGTGGATCCCAACTGTTTCGTTTTGGCACAGTCCATAGTCTTTAGTGCAATGGAGCAAGAGCACTTTAGTGAGTTTCTG CGAAGTCACCATTTCTGTAAATACCAGATTGAAGTGCTGACCAGTGGAACTGTTTACCTGGCTGACATTCTCTTCTGTGAGTCAGCCCTC TTTTATTTCTCTGAGTACATGGAAAAAGAGGATGCAGTGAATATCTTACAATTCTGGTTGGCAGCAGATAACTTCCAGTCTCAGCTTGCT GCCAAAAAGGGCCAATATGATGGACAGGAGGCACAGAATGATGCCATGATTTTATATGACAAGTACTTCTCCCTCCAAGCCACACATCCT CTTGGATTTGATGATGTTGTACGATTAGAAATTGAATCCAATATCTGCAGGGAAGGTGGGCCACTCCCCAACTGTTTCACAACTCCATTA CGTCAGGCCTGGACAACCATGGAGAAGGGCAAGTTTCTGGCTTTTTATCAGTATGCAAAATCATTTAACTCAGATGACTTTGATTATGAA GAGCTGAAGAATGGAGACTACGTCTTCATGAGGTGGAAGGAACAGTTTCTGGTCCCAGATCACACGATCAAAGACATCAGTGGTGCTTCT TTTGCCGGGTTCTACTACATCTGCTTTCAGAAGTCAGCAGCCTCCATAGAGGGCTACTACTACCATAGGAGTTCAGAATGGTATCAGTCC >In-frame_AKAP10_ENST00000395536_chr17_19839599_-_GID4_ENST00000268719_chr17_17962182_+_1764nt ATGAGGGGAGCCGGGCCCTCCCCGCGCCAGTCCCCCCGCACCCTCCGTCCCGACCCGGGCCCCGCCATGTCCTTCTTCCGGCGGAAAGTG AAAGGCAAAGAACAAGAGAAGACCTCAGATGTGAAGTCCATTAAAGCTTCAATATCCGTACATTCCCCACAAAAAAGCACTAAAAATCAT GCCTTGCTGGAGGCTGCAGGACCAAGTCATGTTGCAATCAATGCCATTTCTGCCAACATGGACTCCTTTTCAAGTAGCAGGACAGCCACA CTTAAGAAGCAGCCAAGCCACATGGAGGCCGCTCATTTTGGTGACCTGGGCAGATCTTGTCTGGACTACCAGACTCAAGAGACCAAATCA AGCCTTTCTAAGACCCTTGAACAAGTCTTGCACGACACTATTGTCCTCCCTTACTTCATTCAATTCATGGAACTTCGGCGAATGGAGCAT TTGGTGAAATTTTGGTTAGAGGCTGAAAGTTTTCATTCAACAACTTGGTCGCGAATAAGAGCACACAGTCTAAACACAGTGAAGCAGAGC TCACTGGCTGAGCCTGTCTCTCCATCTAAAAAGCATGAAACTACAGCGTCTTTTTTAACTGATTCTCTTGATAAGAGATTGGAGGATTCT GGCTCAGCACAGTTGTTTATGACTCATTCAGAAGGAATTGACCTGAATAATAGAACTAACAGCACTCAGAATCACTTGCTGCTTTCCCAG GAATGTGACAGTGCCCATTCTCTCCGTCTTGAAATGGCCAGAGCAGGAACTCACCAAGTTTCCATGGAAACCCAAGAATCTTCCTCTACA CTTACAGTAGCCAGTAGAAATAGTCCCGCTTCTCCACTAAAAGAATTGTCAGGAAAACTAATGAAAAGTATAGAACAAGATGCAGTGAAT ACTTTTACCAAATATATATCTCCAGATGCTGCTAAACCAATACCAATTACAGAAGCAATGAGAAATGACATCATAGCAAGGATTTGTGGA GAAGATGGACAGGTGGATCCCAACTGTTTCGTTTTGGCACAGTCCATAGTCTTTAGTGCAATGGAGCAAGAGCACTTTAGTGAGTTTCTG CGAAGTCACCATTTCTGTAAATACCAGATTGAAGTGCTGACCAGTGGAACTGTTTACCTGGCTGACATTCTCTTCTGTGAGTCAGCCCTC TTTTATTTCTCTGAGTACATGGAAAAAGAGGATGCAGTGAATATCTTACAATTCTGGTTGGCAGCAGATAACTTCCAGTCTCAGCTTGCT GCCAAAAAGGGCCAATATGATGGACAGGAGGCACAGAATGATGCCATGATTTTATATGACAAGTACTTCTCCCTCCAAGCCACACATCCT CTTGGATTTGATGATGTTGTACGATTAGAAATTGAATCCAATATCTGCAGGGAAGGTGGGCCACTCCCCAACTGTTTCACAACTCCATTA CGTCAGGCCTGGACAACCATGGAGAAGGGCAAGTTTCTGGCTTTTTATCAGTATGCAAAATCATTTAACTCAGATGACTTTGATTATGAA GAGCTGAAGAATGGAGACTACGTCTTCATGAGGTGGAAGGAACAGTTTCTGGTCCCAGATCACACGATCAAAGACATCAGTGGTGCTTCT TTTGCCGGGTTCTACTACATCTGCTTTCAGAAGTCAGCAGCCTCCATAGAGGGCTACTACTACCATAGGAGTTCAGAATGGTATCAGTCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AKAP10_ENST00000225737_chr17_19839599_-_GID4_ENST00000268719_chr17_17962182_+_5083nt AAGGACCGGAACTCCGGGCGGGCGGCTTGTTGATAATATGGCGGCTGGAGCTGCCTGGGCATCCCGAGGAGGCGGTGGGGCCCACTCCCG GAAGAAGGGTCCCTTTTCGCGCTAGTGCAGCGGCCCCTCTGGACCCGGAAGTCCGGGCCGGTTGCTGAATGAGGGGAGCCGGGCCCTCCC CGCGCCAGTCCCCCCGCACCCTCCGTCCCGACCCGGGCCCCGCCATGTCCTTCTTCCGGCGGAAAGTGAAAGGCAAAGAACAAGAGAAGA CCTCAGATGTGAAGTCCATTAAAGCTTCAATATCCGTACATTCCCCACAAAAAAGCACTAAAAATCATGCCTTGCTGGAGGCTGCAGGAC CAAGTCATGTTGCAATCAATGCCATTTCTGCCAACATGGACTCCTTTTCAAGTAGCAGGACAGCCACACTTAAGAAGCAGCCAAGCCACA TGGAGGCCGCTCATTTTGGTGACCTGGGCAGATCTTGTCTGGACTACCAGACTCAAGAGACCAAATCAAGCCTTTCTAAGACCCTTGAAC AAGTCTTGCACGACACTATTGTCCTCCCTTACTTCATTCAATTCATGGAACTTCGGCGAATGGAGCATTTGGTGAAATTTTGGTTAGAGG CTGAAAGTTTTCATTCAACAACTTGGTCGCGAATAAGAGCACACAGTCTAAACACAGTGAAGCAGAGCTCACTGGCTGAGCCTGTCTCTC CATCTAAAAAGCATGAAACTACAGCGTCTTTTTTAACTGATTCTCTTGATAAGAGATTGGAGGATTCTGGCTCAGCACAGTTGTTTATGA CTCATTCAGAAGGAATTGACCTGAATAATAGAACTAACAGCACTCAGAATCACTTGCTGCTTTCCCAGGAATGTGACAGTGCCCATTCTC TCCGTCTTGAAATGGCCAGAGCAGGAACTCACCAAGTTTCCATGGAAACCCAAGAATCTTCCTCTACACTTACAGTAGCCAGTAGAAATA GTCCCGCTTCTCCACTAAAAGAATTGTCAGGAAAACTAATGAAAAGTATAGAACAAGATGCAGTGAATACTTTTACCAAATATATATCTC CAGATGCTGCTAAACCAATACCAATTACAGAAGCAATGAGAAATGACATCATAGCAAGGATTTGTGGAGAAGATGGACAGGTGGATCCCA ACTGTTTCGTTTTGGCACAGTCCATAGTCTTTAGTGCAATGGAGCAAGAGCACTTTAGTGAGTTTCTGCGAAGTCACCATTTCTGTAAAT ACCAGATTGAAGTGCTGACCAGTGGAACTGTTTACCTGGCTGACATTCTCTTCTGTGAGTCAGCCCTCTTTTATTTCTCTGAGTACATGG AAAAAGAGGATGCAGTGAATATCTTACAATTCTGGTTGGCAGCAGATAACTTCCAGTCTCAGCTTGCTGCCAAAAAGGGCCAATATGATG GACAGGAGGCACAGAATGATGCCATGATTTTATATGACAAGTACTTCTCCCTCCAAGCCACACATCCTCTTGGATTTGATGATGTTGTAC GATTAGAAATTGAATCCAATATCTGCAGGGAAGGTGGGCCACTCCCCAACTGTTTCACAACTCCATTACGTCAGGCCTGGACAACCATGG AGAAGGGCAAGTTTCTGGCTTTTTATCAGTATGCAAAATCATTTAACTCAGATGACTTTGATTATGAAGAGCTGAAGAATGGAGACTACG TCTTCATGAGGTGGAAGGAACAGTTTCTGGTCCCAGATCACACGATCAAAGACATCAGTGGTGCTTCTTTTGCCGGGTTCTACTACATCT GCTTTCAGAAGTCAGCAGCCTCCATAGAGGGCTACTACTACCATAGGAGTTCAGAATGGTATCAGTCCCTCAATCTAACCCATGTTCCTG AACACAGTGCACCCATCTATGAATTCCGGTGACAACGGTTCAGAACAGCAACCAAATAAAACTGAACTTGGCAAAAAAGAACTTTGCCGA GAAAATTGTGTACCTGCCAGAACCAGGAGAAGTGTGTTCCTGTTTCTTCACGAGCAGACTCGCATCACAAAGCATGAATGTTAACCCACA GAATCCAAGGAGCATGGCTGGCCCGTGGGGCAGGTGGAGGGAGCAGTCTTCGTTCTTCCTCCCCTCAGTGGCAGTTTGGTCTTCACCTGT TTTTAAGCTACCTTAAACGCACTTTTCCTTCCTGCACAGCTAACTTCTACATCACTGAAATGCCCATTCCTTCCTCCGTCCCACCTCCAG CCGAATAGAAGGTCTGCTCCCGGATCACCCTCAGCCTTGGTGCTCAGTGGTCCCGAGGCCCTAGACCCCCACCCCCCGCCAGTTGCTTTG TCTGGTAGCTCAAGAGAAGGCAGAGCCCCAGCACCTCTGTGCCCCCCAGAGCTCTGTGCAGGGAGTTGGCCAGCTGCCGCATCATCGGCC ACCAAGGGCACAAGAGGCGGAGGCTCCAGTCCCTGCTGGGCTGCCTCAGTCTTCAGTGCTGATTGTGTCACGGGTCAGCGTGCGCTGCTG AGCCCTGTACTGTTAACAGTGCAAAGCTAGTGAGTAGCTGTCAGGTTCCCTGGGCCTGCCATCAGGGATCACTAAATTTAAGGCTTCCAG ATCCCTGGCAGGAACAGATTCCAGTCCTGCTTACTCAGTACATTTGCTCCAAACTTTTCAACTTGAGGGCAATACTAAACTTAAAAATAA GAGTTTTTTTATTACAAAATTATTTTTATGGTCCCTTTAACGAGGACCCTATGGCAAATGCACAATTATTCAGAATTACATTTTATCGTT TTCACATTGAAAACAGCAAATGTTGACTTAGTAATTTTTATATCGATATCTATATGTATATGTATATTTAATCAACCAGCAGTTTTGAAA CTAGTCATCCTGGTACAAAAGTTTTGCAGCATTGCCTAAATTATAGTGCTCAACACAAGAACTGTTTTTGGGGCCAGTTTAGCATTTGTG CCGCCTCCTTTTGCTACTCAAAACAGCAATGCTTGGCGGCAGCCTTCCATGAGGCAGAAGGGGTCGTCGTTCTCTGAAAACAGTGACTCT GAAATGTTGGGACAGGGGAAGGGGTGGGAAACATGAACATGCTCAAATAACTCGAGGCTCACGTGCCAAAGTGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTATGATGTTTTGTTTTTTTAAATGTTTTAAAAGCTTAATAGGTTGGCATCAGTTGTAGCCCACAAACATGGCTAGGG CTTTGGGGATTTGGCATTTTTCTGGTGGTTTACAAGACTTACTCCGAATACAAGAGGAAAAGCTTTAAAAACAAGATTGCATCATAACCC CCAGGAGCAAAGCAACCTGGAGGCTGCATATCCATGGGCGGGCAGCATAAGAGAATGTGAAGCCCTTCAGTGAGACGAGACGAGCAATGG GAAACCTTTTCTGTTCTTAAGAAGTGACTTTAATTTTATTGACATATGTACTGTATGTTACTGAGATTGAATGTTAGGGGAAGCCTTAAG GTAGAGGTATTTGGGAAAGTAGCCAGTGGGCACTTGTGATATCTAAAATCTGTTATCCCAGGACTGTGTACAGAGGGGCAACCTACCCAT TCAGGAAGGTCAGGGCTTTGGAACCCTAAAAAGTTGGCCCGATGACTTAAAGGGAAAAATAATTCATTCCCAGAGATGAGTCAGAACAGT CTCCTCAATCCTGAAATTCAACAAGGCATCAGAAGGGCTGGCTGTGGTCAAGCCCAGCTGCTGTCATGTGAGGAGATGCTCACTGTGGTC TTGTTGAGCTGATGGCCTTGGTTGAGCTGATGGACAAGTGAAGGAGGCCATGGGGCTGTGCTGTCCTTCCTGCCGTACGTGCCATTCCAC TCTCTTCAGCTCTCCCCTCAACAGCATGCGAGCCCATACCTTCTGCATTTTTCCAGGCCTGTGAGGGATATAGGCCTCCCCTTGGAGCAC TGAGTCCGGAGGTCATCCCTGAGCTCATCCACGGCTCATGCTGTGGCTCCGAGTAGTGGTTTGAGTGGGCAGGAAGGGCCATTTGCAAAC ACTGCTGTGTTCTAGACAAACAACCCAAGTCCTATGGCAGGATTTCTTCCTTCCTTCCTTTTTTACCCAGGTGATGAAGTGCACCCATTG TACTGGGAAGAATGAAGAGGTGATACCTTTACTAGATCCTTCAGACACATCTATGAGAAGATTTGTTCATTTAAAAGTCTGCCCACTGAG GATAGGGAAAGGATTAAGGATTTTTCCACCTCCTCTTAGTAACTCCTGAATTACCAACATCAACTTCTTTCTCTCCGTTCCTGAAGGAAC TTTGGGGAATCATCTTCATCCGTAGTTACGCTTTCCTGAACCTTCTCAGTGGTTTACATGCCTCTGAAACTATGTGCAATATTTTTGGTT GACACTTGTATCCATCCTTAAGAAATTAGTGCAGATTGCAGATGTTCTGTCTTCCATCCCAAACAAGCCTGCCATGAGGTAGGATCCTAG GGGTTTGGCTGTTCTTACTCCACTGCTCAGAAAGCTTCCATTCTGCTGTCCTCAGCCTCGACCCTCTTCTGTGCTGGACTTCCACCCACC CACCCTTTTCAAGTTTAGATAGTGTTTCAGCTGCTGTCCCAAAGTAACAAAACAATACCTACTGTTAAGTAGGAAGTCAATCTGTGTGCT GGTTTTGTTGGTTATGTGGAAATCACAAACTCCAGAGGAGCAAAGGGGTTTTTCAATGTCTTTTGCTTTCAGAAACAGAGAATATAATAT TCTCACTAAGGCCTTGAATTGATTTTTTTCTCATAAAATAGTCTGATAAGCTAATTTTTAAAAAGAAATGCCATTAACTGTGTTGTATCG TGGTTTAAAATTACTAACAAGTTGTGGGAAAGAAAAATAATATTTGATTTTGAATCTTAAATGTTTTTAAAAATTAGACTTGAATGGGCA CAAAGTATAAATATTTTGTTTCTTTATGGAGGACATGTGGAAGGAGTTTGAGGGTTTGGGATGGGAGAAGTATTTTGCAGAGCTATCAAT >In-frame_AKAP10_ENST00000395536_chr17_19839599_-_GID4_ENST00000268719_chr17_17962182_+_4925nt ATGAGGGGAGCCGGGCCCTCCCCGCGCCAGTCCCCCCGCACCCTCCGTCCCGACCCGGGCCCCGCCATGTCCTTCTTCCGGCGGAAAGTG AAAGGCAAAGAACAAGAGAAGACCTCAGATGTGAAGTCCATTAAAGCTTCAATATCCGTACATTCCCCACAAAAAAGCACTAAAAATCAT GCCTTGCTGGAGGCTGCAGGACCAAGTCATGTTGCAATCAATGCCATTTCTGCCAACATGGACTCCTTTTCAAGTAGCAGGACAGCCACA CTTAAGAAGCAGCCAAGCCACATGGAGGCCGCTCATTTTGGTGACCTGGGCAGATCTTGTCTGGACTACCAGACTCAAGAGACCAAATCA AGCCTTTCTAAGACCCTTGAACAAGTCTTGCACGACACTATTGTCCTCCCTTACTTCATTCAATTCATGGAACTTCGGCGAATGGAGCAT TTGGTGAAATTTTGGTTAGAGGCTGAAAGTTTTCATTCAACAACTTGGTCGCGAATAAGAGCACACAGTCTAAACACAGTGAAGCAGAGC TCACTGGCTGAGCCTGTCTCTCCATCTAAAAAGCATGAAACTACAGCGTCTTTTTTAACTGATTCTCTTGATAAGAGATTGGAGGATTCT GGCTCAGCACAGTTGTTTATGACTCATTCAGAAGGAATTGACCTGAATAATAGAACTAACAGCACTCAGAATCACTTGCTGCTTTCCCAG GAATGTGACAGTGCCCATTCTCTCCGTCTTGAAATGGCCAGAGCAGGAACTCACCAAGTTTCCATGGAAACCCAAGAATCTTCCTCTACA CTTACAGTAGCCAGTAGAAATAGTCCCGCTTCTCCACTAAAAGAATTGTCAGGAAAACTAATGAAAAGTATAGAACAAGATGCAGTGAAT ACTTTTACCAAATATATATCTCCAGATGCTGCTAAACCAATACCAATTACAGAAGCAATGAGAAATGACATCATAGCAAGGATTTGTGGA GAAGATGGACAGGTGGATCCCAACTGTTTCGTTTTGGCACAGTCCATAGTCTTTAGTGCAATGGAGCAAGAGCACTTTAGTGAGTTTCTG CGAAGTCACCATTTCTGTAAATACCAGATTGAAGTGCTGACCAGTGGAACTGTTTACCTGGCTGACATTCTCTTCTGTGAGTCAGCCCTC TTTTATTTCTCTGAGTACATGGAAAAAGAGGATGCAGTGAATATCTTACAATTCTGGTTGGCAGCAGATAACTTCCAGTCTCAGCTTGCT GCCAAAAAGGGCCAATATGATGGACAGGAGGCACAGAATGATGCCATGATTTTATATGACAAGTACTTCTCCCTCCAAGCCACACATCCT CTTGGATTTGATGATGTTGTACGATTAGAAATTGAATCCAATATCTGCAGGGAAGGTGGGCCACTCCCCAACTGTTTCACAACTCCATTA CGTCAGGCCTGGACAACCATGGAGAAGGGCAAGTTTCTGGCTTTTTATCAGTATGCAAAATCATTTAACTCAGATGACTTTGATTATGAA GAGCTGAAGAATGGAGACTACGTCTTCATGAGGTGGAAGGAACAGTTTCTGGTCCCAGATCACACGATCAAAGACATCAGTGGTGCTTCT TTTGCCGGGTTCTACTACATCTGCTTTCAGAAGTCAGCAGCCTCCATAGAGGGCTACTACTACCATAGGAGTTCAGAATGGTATCAGTCC CTCAATCTAACCCATGTTCCTGAACACAGTGCACCCATCTATGAATTCCGGTGACAACGGTTCAGAACAGCAACCAAATAAAACTGAACT TGGCAAAAAAGAACTTTGCCGAGAAAATTGTGTACCTGCCAGAACCAGGAGAAGTGTGTTCCTGTTTCTTCACGAGCAGACTCGCATCAC AAAGCATGAATGTTAACCCACAGAATCCAAGGAGCATGGCTGGCCCGTGGGGCAGGTGGAGGGAGCAGTCTTCGTTCTTCCTCCCCTCAG TGGCAGTTTGGTCTTCACCTGTTTTTAAGCTACCTTAAACGCACTTTTCCTTCCTGCACAGCTAACTTCTACATCACTGAAATGCCCATT CCTTCCTCCGTCCCACCTCCAGCCGAATAGAAGGTCTGCTCCCGGATCACCCTCAGCCTTGGTGCTCAGTGGTCCCGAGGCCCTAGACCC CCACCCCCCGCCAGTTGCTTTGTCTGGTAGCTCAAGAGAAGGCAGAGCCCCAGCACCTCTGTGCCCCCCAGAGCTCTGTGCAGGGAGTTG GCCAGCTGCCGCATCATCGGCCACCAAGGGCACAAGAGGCGGAGGCTCCAGTCCCTGCTGGGCTGCCTCAGTCTTCAGTGCTGATTGTGT CACGGGTCAGCGTGCGCTGCTGAGCCCTGTACTGTTAACAGTGCAAAGCTAGTGAGTAGCTGTCAGGTTCCCTGGGCCTGCCATCAGGGA TCACTAAATTTAAGGCTTCCAGATCCCTGGCAGGAACAGATTCCAGTCCTGCTTACTCAGTACATTTGCTCCAAACTTTTCAACTTGAGG GCAATACTAAACTTAAAAATAAGAGTTTTTTTATTACAAAATTATTTTTATGGTCCCTTTAACGAGGACCCTATGGCAAATGCACAATTA TTCAGAATTACATTTTATCGTTTTCACATTGAAAACAGCAAATGTTGACTTAGTAATTTTTATATCGATATCTATATGTATATGTATATT TAATCAACCAGCAGTTTTGAAACTAGTCATCCTGGTACAAAAGTTTTGCAGCATTGCCTAAATTATAGTGCTCAACACAAGAACTGTTTT TGGGGCCAGTTTAGCATTTGTGCCGCCTCCTTTTGCTACTCAAAACAGCAATGCTTGGCGGCAGCCTTCCATGAGGCAGAAGGGGTCGTC GTTCTCTGAAAACAGTGACTCTGAAATGTTGGGACAGGGGAAGGGGTGGGAAACATGAACATGCTCAAATAACTCGAGGCTCACGTGCCA AAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGATGTTTTGTTTTTTTAAATGTTTTAAAAGCTTAATAGGTTGGCATCAGTTG TAGCCCACAAACATGGCTAGGGCTTTGGGGATTTGGCATTTTTCTGGTGGTTTACAAGACTTACTCCGAATACAAGAGGAAAAGCTTTAA AAACAAGATTGCATCATAACCCCCAGGAGCAAAGCAACCTGGAGGCTGCATATCCATGGGCGGGCAGCATAAGAGAATGTGAAGCCCTTC AGTGAGACGAGACGAGCAATGGGAAACCTTTTCTGTTCTTAAGAAGTGACTTTAATTTTATTGACATATGTACTGTATGTTACTGAGATT GAATGTTAGGGGAAGCCTTAAGGTAGAGGTATTTGGGAAAGTAGCCAGTGGGCACTTGTGATATCTAAAATCTGTTATCCCAGGACTGTG TACAGAGGGGCAACCTACCCATTCAGGAAGGTCAGGGCTTTGGAACCCTAAAAAGTTGGCCCGATGACTTAAAGGGAAAAATAATTCATT CCCAGAGATGAGTCAGAACAGTCTCCTCAATCCTGAAATTCAACAAGGCATCAGAAGGGCTGGCTGTGGTCAAGCCCAGCTGCTGTCATG TGAGGAGATGCTCACTGTGGTCTTGTTGAGCTGATGGCCTTGGTTGAGCTGATGGACAAGTGAAGGAGGCCATGGGGCTGTGCTGTCCTT CCTGCCGTACGTGCCATTCCACTCTCTTCAGCTCTCCCCTCAACAGCATGCGAGCCCATACCTTCTGCATTTTTCCAGGCCTGTGAGGGA TATAGGCCTCCCCTTGGAGCACTGAGTCCGGAGGTCATCCCTGAGCTCATCCACGGCTCATGCTGTGGCTCCGAGTAGTGGTTTGAGTGG GCAGGAAGGGCCATTTGCAAACACTGCTGTGTTCTAGACAAACAACCCAAGTCCTATGGCAGGATTTCTTCCTTCCTTCCTTTTTTACCC AGGTGATGAAGTGCACCCATTGTACTGGGAAGAATGAAGAGGTGATACCTTTACTAGATCCTTCAGACACATCTATGAGAAGATTTGTTC ATTTAAAAGTCTGCCCACTGAGGATAGGGAAAGGATTAAGGATTTTTCCACCTCCTCTTAGTAACTCCTGAATTACCAACATCAACTTCT TTCTCTCCGTTCCTGAAGGAACTTTGGGGAATCATCTTCATCCGTAGTTACGCTTTCCTGAACCTTCTCAGTGGTTTACATGCCTCTGAA ACTATGTGCAATATTTTTGGTTGACACTTGTATCCATCCTTAAGAAATTAGTGCAGATTGCAGATGTTCTGTCTTCCATCCCAAACAAGC CTGCCATGAGGTAGGATCCTAGGGGTTTGGCTGTTCTTACTCCACTGCTCAGAAAGCTTCCATTCTGCTGTCCTCAGCCTCGACCCTCTT CTGTGCTGGACTTCCACCCACCCACCCTTTTCAAGTTTAGATAGTGTTTCAGCTGCTGTCCCAAAGTAACAAAACAATACCTACTGTTAA GTAGGAAGTCAATCTGTGTGCTGGTTTTGTTGGTTATGTGGAAATCACAAACTCCAGAGGAGCAAAGGGGTTTTTCAATGTCTTTTGCTT TCAGAAACAGAGAATATAATATTCTCACTAAGGCCTTGAATTGATTTTTTTCTCATAAAATAGTCTGATAAGCTAATTTTTAAAAAGAAA TGCCATTAACTGTGTTGTATCGTGGTTTAAAATTACTAACAAGTTGTGGGAAAGAAAAATAATATTTGATTTTGAATCTTAAATGTTTTT AAAAATTAGACTTGAATGGGCACAAAGTATAAATATTTTGTTTCTTTATGGAGGACATGTGGAAGGAGTTTGAGGGTTTGGGATGGGAGA |
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FusionGenePPI for AKAP10_GID4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AKAP10 | PRKAR1A, PDZK1, HAX1, COG3, DCTN4, MYH9, TRIM25 | GID4 | MOV10, GDNF, GLIPR1L2, MMP7, TDGF1, MRPL4, GPS2, MRPL39, PDHB, HLA-DPB1, RMND5A, IKZF3, ADCYAP1, PRG2, BMP1, TIGD5, INSL6, PRG3, CCDC120, MPP2, CUTA, NDUFS6, PIGT, JPH4, PRICKLE3, LILRB4, PDGFD, NEU4, RANBP10, MKLN1, MAEA, ARMC8, WDR26, RANBP9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AKAP10_GID4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AKAP10_GID4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AKAP10 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
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