FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13008

FusionGeneSummary for FBF1_HELZ

check button Fusion gene summary
Fusion gene informationFusion gene name: FBF1_HELZ
Fusion gene ID: 13008
HgeneTgene
Gene symbol

FBF1

HELZ

Gene ID

85302

9931

Gene nameFas binding factor 1helicase with zinc finger
SynonymsAlb|FBF-1DHRC|DRHC|HUMORF5
Cytomap

17q25.1

17q24.2

Type of geneprotein-codingprotein-coding
Descriptionfas-binding factor 1Fas (TNFRSF6) binding factor 1Fas binding protein 1albatrossprotein albatrossprobable helicase with zinc finger domaindown-regulated in human cancers proteinhelicase with zinc finger domain
Modification date2018051920180526
UniProtAcc

Q8TES7

P42694

Ensembl transtripts involved in fusion geneENST00000586717, ENST00000319129, 
ENST00000389570, ENST00000586631, 
ENST00000588478, 
ENST00000358691, 
ENST00000580168, ENST00000580662, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 3=90
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBF1 [Title/Abstract] AND HELZ [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-78-7146-01AFBF1chr17

73933647

-HELZchr17

65134230

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000586717ENST00000358691FBF1chr17

73933647

-HELZchr17

65134230

-
Frame-shiftENST00000586717ENST00000580168FBF1chr17

73933647

-HELZchr17

65134230

-
5CDS-intronENST00000586717ENST00000580662FBF1chr17

73933647

-HELZchr17

65134230

-
Frame-shiftENST00000319129ENST00000358691FBF1chr17

73933647

-HELZchr17

65134230

-
Frame-shiftENST00000319129ENST00000580168FBF1chr17

73933647

-HELZchr17

65134230

-
5CDS-intronENST00000319129ENST00000580662FBF1chr17

73933647

-HELZchr17

65134230

-
Frame-shiftENST00000389570ENST00000358691FBF1chr17

73933647

-HELZchr17

65134230

-
Frame-shiftENST00000389570ENST00000580168FBF1chr17

73933647

-HELZchr17

65134230

-
5CDS-intronENST00000389570ENST00000580662FBF1chr17

73933647

-HELZchr17

65134230

-
intron-3CDSENST00000586631ENST00000358691FBF1chr17

73933647

-HELZchr17

65134230

-
intron-3CDSENST00000586631ENST00000580168FBF1chr17

73933647

-HELZchr17

65134230

-
intron-intronENST00000586631ENST00000580662FBF1chr17

73933647

-HELZchr17

65134230

-
intron-3CDSENST00000588478ENST00000358691FBF1chr17

73933647

-HELZchr17

65134230

-
intron-3CDSENST00000588478ENST00000580168FBF1chr17

73933647

-HELZchr17

65134230

-
intron-intronENST00000588478ENST00000580662FBF1chr17

73933647

-HELZchr17

65134230

-

Top

FusionProtFeatures for FBF1_HELZ


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBF1

Q8TES7

HELZ

P42694

Keratin-binding protein required for epithelial cellpolarization. Involved in apical junction complex (AJC) assemblyvia its interaction with PARD3. Required for ciliogenesis.{ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. May act as a helicase that plays a role in RNAmetabolism in multiple tissues and organs within the developingembryo.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FBF1_HELZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FBF1_HELZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FBF1CALCOCO2, TRIM27, CCDC85B, RHOXF2, USHBP1, HIF1AN, IFT20, GCC1, ACCS, TUBGCP4, TRAF2, TRIM29, TCEA2, FAS, CUL3, CUL4B, CUL2, CUL1, DCUN1D1, CAND1, APP, ANKRD28, DGCR6, VCP, AES, TRIM23, GATA1, GOLGA2, KRT13, KRT31, MEOX2, TADA2A, TRAF1, SUMO1, BLZF1, PNMA1, TMCC2, RBPMS, MID2, IKZF3, ABI3, CINP, FAM208B, CEP55, TEX11, TRIM54, VPS37B, CCDC102B, CEP63, TSGA10, LZTS2, SSX2IP, KRT40, TTC32, MIPOL1, CCDC67, USP7, CLK1, CEP128, ABLIM1, ACADSB, ADSL, AGK, CEP131, BCAS3, TMEM256, CBL, CC2D1A, CCDC85C, CCNB1, CEP170, CEP85, CLTC, CPVL, CSPP1, CTBP1, CTSB, DNM2, DNMBP, EIF4ENIF1, ERC1, FAM21A, FLOT1, GARS, GPATCH1, GRB2, HAUS3, HAUS6, HAUS8, HK1, HYOU1, IFT74, IFT81, IGF2BP2, ITSN2, LASP1, MGST3, MYCBPAP, NEDD1, NMT1, NNT, NRBF2, NT5C2, PCM1, PEA15, PLK1, PRKRA, RBM14-RBM4, SCFD1, SCLT1, SDCCAG3, SDHC, SEC24B, SIRT2, SNX9, SORBS1, SRSF2, STAM, STAM2, STT3B, TIMM23B, TJP1, TJP2, TNIP1, TNRC6B, TP53BP2, TRIM26, TSFM, TTLL12, TXLNA, TXLNG, UNC45A, VCL, WDR83, YARS2, CARHSP1, CEP192, FKBP15, OFD1, PDIA3, PRKACA, PSMD7, RAB2A, RAB7A, SCRIB, SPTBN5HELZSMYD3, SH3YL1, GRB2, ELAVL1, SIRT7, MYC, STAT5A, TARDBP, SAV1, TUBG1, NXF1, BMI1, KLHL20, BCAT1, GNB2L1, RCBTB1, RBFOX2, CHIA, CCNJL, FBXW11, CLTC, SEC16A, GAN, DUSP18, EYA2, EYA4, PIGT, CELA3A, ESRP1, CELA1, CLASRP, NXF2, THSD4, HCFC2, KIAA0430, NISCH, SOWAHA, EIF4ENIF1, PAN2, PCGF5, PCGF3, CTBP1, CREBBP, ARID3A, KIAA1671, POM121C, ERF, C15orf39, FBRS, NUP50, ECSIT, RBL1, RB1, POM121, PAN3, CTBP2, RNF2, EBF3, ARID3B, FBXL19, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FBF1_HELZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FBF1_HELZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource