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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13001

FusionGeneSummary for FAU_PLIN3

check button Fusion gene summary
Fusion gene informationFusion gene name: FAU_PLIN3
Fusion gene ID: 13001
HgeneTgene
Gene symbol

FAU

PLIN3

Gene ID

2197

10226

Gene nameFAU, ubiquitin like and ribosomal protein S30 fusionperilipin 3
SynonymsFAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1M6PRBP1|PP17|TIP47
Cytomap

11q13.1

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-like protein fubi and ribosomal protein S3040S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monocloperilipin-347 kDa MPR-binding proteincargo selection protein TIP47mannose-6-phosphate receptor-binding protein 1placental protein 17tail-interacting protein, 47 kDtesticular tissue protein Li 114
Modification date2018052220180522
UniProtAcc

P62861

O60664

Ensembl transtripts involved in fusion geneENST00000529639, ENST00000531743, 
ENST00000525297, ENST00000527548, 
ENST00000279259, ENST00000529259, 
ENST00000434372, 
ENST00000221957, 
ENST00000592528, ENST00000585479, 
Fusion gene scores* DoF score7 X 7 X 2=983 X 3 X 1=9
# samples 86
** MAII scorelog2(8/98*10)=-0.292781749227846
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/9*10)=2.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAU [Title/Abstract] AND PLIN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ712941FAUchr11

64888257

-PLIN3chr19

4839219

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000529639ENST00000221957FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000529639ENST00000592528FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000529639ENST00000585479FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000531743ENST00000221957FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000531743ENST00000592528FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000531743ENST00000585479FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000525297ENST00000221957FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000525297ENST00000592528FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000525297ENST00000585479FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000527548ENST00000221957FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000527548ENST00000592528FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000527548ENST00000585479FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000279259ENST00000221957FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000279259ENST00000592528FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000279259ENST00000585479FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000529259ENST00000221957FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000529259ENST00000592528FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000529259ENST00000585479FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000434372ENST00000221957FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000434372ENST00000592528FAUchr11

64888257

-PLIN3chr19

4839219

-
intron-3CDSENST00000434372ENST00000585479FAUchr11

64888257

-PLIN3chr19

4839219

-

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FusionProtFeatures for FAU_PLIN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAU

P62861

PLIN3

O60664

Required for the transport of mannose 6-phosphatereceptors (MPR) from endosomes to the trans-Golgi network.{ECO:0000269|PubMed:9590177}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAU_PLIN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAU_PLIN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAU_PLIN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePLIN3O60664DB01271IdursulfasePerilipin-3biotechapproved
TgenePLIN3O60664DB01279GalsulfasePerilipin-3biotechapproved|investigational

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RelatedDiseases for FAU_PLIN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLIN3C0023893Liver Cirrhosis, Experimental1CTD_human