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Fusion gene ID: 1300 |
FusionGeneSummary for AKAP10_CCL3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: AKAP10_CCL3 | Fusion gene ID: 1300 | Hgene | Tgene | Gene symbol | AKAP10 | CCL3 | Gene ID | 11216 | 6348 |
Gene name | A-kinase anchoring protein 10 | C-C motif chemokine ligand 3 | |
Synonyms | AKAP-10|D-AKAP-2|D-AKAP2|PRKA10 | G0S19-1|LD78ALPHA|MIP-1-alpha|MIP1A|SCYA3 | |
Cytomap | 17p11.2 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | A-kinase anchor protein 10, mitochondrialA kinase (PRKA) anchor protein 10A kinase anchor protein 10dual specificity A kinase-anchoring protein 2mitochondrial A kinase PPKA anchor protein 10protein kinase A anchoring protein 10 | C-C motif chemokine 3G0/G1 switch regulatory protein 19-1PAT 464.1SIS-betachemokine (C-C motif) ligand 3macrophage inflammatory protein 1-alphasmall inducible cytokine A3 (homologous to mouse Mip-1a)tonsillar lymphocyte LD78 alpha protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O43572 | P10147 | |
Ensembl transtripts involved in fusion gene | ENST00000225737, ENST00000395536, ENST00000572155, | ENST00000225245, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: AKAP10 [Title/Abstract] AND CCL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CCL3 | GO:0001775 | cell activation | 10706735 |
Tgene | CCL3 | GO:0002548 | monocyte chemotaxis | 10706735 |
Tgene | CCL3 | GO:0006816 | calcium ion transport | 10734056 |
Tgene | CCL3 | GO:0006874 | cellular calcium ion homeostasis | 10072545|10734056|21403648 |
Tgene | CCL3 | GO:0006887 | exocytosis | 10734056 |
Tgene | CCL3 | GO:0006935 | chemotaxis | 10679098 |
Tgene | CCL3 | GO:0006954 | inflammatory response | 10679098|10706735|21147091 |
Tgene | CCL3 | GO:0007010 | cytoskeleton organization | 10072545 |
Tgene | CCL3 | GO:0007267 | cell-cell signaling | 10679098 |
Tgene | CCL3 | GO:0008360 | regulation of cell shape | 10072545 |
Tgene | CCL3 | GO:0009636 | response to toxic substance | 10841574 |
Tgene | CCL3 | GO:0010628 | positive regulation of gene expression | 10706735 |
Tgene | CCL3 | GO:0010629 | negative regulation of gene expression | 21403648 |
Tgene | CCL3 | GO:0010818 | T cell chemotaxis | 10706735 |
Tgene | CCL3 | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 19523456 |
Tgene | CCL3 | GO:0019722 | calcium-mediated signaling | 10072545|19523456 |
Tgene | CCL3 | GO:0030335 | positive regulation of cell migration | 7545673|10706735 |
Tgene | CCL3 | GO:0030502 | negative regulation of bone mineralization | 21403648 |
Tgene | CCL3 | GO:0030593 | neutrophil chemotaxis | 10706735 |
Tgene | CCL3 | GO:0031663 | lipopolysaccharide-mediated signaling pathway | 21147091 |
Tgene | CCL3 | GO:0043308 | eosinophil degranulation | 10706735 |
Tgene | CCL3 | GO:0043922 | negative regulation by host of viral transcription | 10841574 |
Tgene | CCL3 | GO:0045671 | negative regulation of osteoclast differentiation | 21403648 |
Tgene | CCL3 | GO:0048245 | eosinophil chemotaxis | 10072545 |
Tgene | CCL3 | GO:0048247 | lymphocyte chemotaxis | 10706735 |
Tgene | CCL3 | GO:0050795 | regulation of behavior | 20167378 |
Tgene | CCL3 | GO:0051928 | positive regulation of calcium ion transport | 8699119|15764707 |
Tgene | CCL3 | GO:0051930 | regulation of sensory perception of pain | 15764707 |
Tgene | CCL3 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 21403648 |
Tgene | CCL3 | GO:0070723 | response to cholesterol | 19523456 |
Tgene | CCL3 | GO:0071407 | cellular response to organic cyclic compound | 21147091 |
Tgene | CCL3 | GO:0071621 | granulocyte chemotaxis | 10706735 |
Tgene | CCL3 | GO:2000503 | positive regulation of natural killer cell chemotaxis | 7545673 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-FX-A3TO-01A | AKAP10 | chr17 | 19880905 | - | CCL3 | chr17 | 34416643 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000225737 | ENST00000225245 | AKAP10 | chr17 | 19880905 | - | CCL3 | chr17 | 34416643 | - |
Frame-shift | ENST00000395536 | ENST00000225245 | AKAP10 | chr17 | 19880905 | - | CCL3 | chr17 | 34416643 | - |
intron-3CDS | ENST00000572155 | ENST00000225245 | AKAP10 | chr17 | 19880905 | - | CCL3 | chr17 | 34416643 | - |
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FusionProtFeatures for AKAP10_CCL3 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
AKAP10 | CCL3 |
Differentially targeted protein that binds to type I andII regulatory subunits of protein kinase A and anchors them to themitochondria or the plasma membrane. Although the physiologicalrelevance between PKA and AKAPS with mitochondria is not fullyunderstood, one idea is that BAD, a proapoptotic member, isphosphorylated and inactivated by mitochondria-anchored PKA. Itcannot be excluded too that it may facilitate PKA as well as Gprotein signal transduction, by acting as an adapter forassembling multiprotein complexes. With its RGS domain, it couldlead to the interaction to G-alpha proteins, providing a linkbetween the signaling machinery and the downstream kinase (Bysimilarity). {ECO:0000250}. | Monokine with inflammatory and chemokinetic properties.Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressivefactors produced by CD8+ T-cells. Recombinant MIP-1-alpha inducesa dose-dependent inhibition of different strains of HIV-1, HIV-2,and simian immunodeficiency virus (SIV).{ECO:0000269|PubMed:8525373}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AKAP10_CCL3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AKAP10_CCL3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AKAP10 | PRKAR1A, PDZK1, HAX1, COG3, DCTN4, MYH9, TRIM25 | CCL3 | CCR5, CCL3, CCL4, CCR4, ZFP36 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AKAP10_CCL3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AKAP10_CCL3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AKAP10 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | CCL3 | C0007786 | Brain Ischemia | 2 | CTD_human |
Tgene | CCL3 | C0020517 | Hypersensitivity | 2 | CTD_human |
Tgene | CCL3 | C0034069 | Pulmonary Fibrosis | 2 | CTD_human |
Tgene | CCL3 | C0004153 | Atherosclerosis | 1 | CTD_human |
Tgene | CCL3 | C0017658 | Glomerulonephritis | 1 | CTD_human |
Tgene | CCL3 | C0021368 | Inflammation | 1 | CTD_human |
Tgene | CCL3 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Tgene | CCL3 | C0038220 | Status Epilepticus | 1 | CTD_human |
Tgene | CCL3 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | CCL3 | C0273115 | Lung Injury | 1 | CTD_human |
Tgene | CCL3 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | CCL3 | C2239176 | Liver carcinoma | 1 | CTD_human |