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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1300

FusionGeneSummary for AKAP10_CCL3

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP10_CCL3
Fusion gene ID: 1300
HgeneTgene
Gene symbol

AKAP10

CCL3

Gene ID

11216

6348

Gene nameA-kinase anchoring protein 10C-C motif chemokine ligand 3
SynonymsAKAP-10|D-AKAP-2|D-AKAP2|PRKA10G0S19-1|LD78ALPHA|MIP-1-alpha|MIP1A|SCYA3
Cytomap

17p11.2

17q12

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 10, mitochondrialA kinase (PRKA) anchor protein 10A kinase anchor protein 10dual specificity A kinase-anchoring protein 2mitochondrial A kinase PPKA anchor protein 10protein kinase A anchoring protein 10C-C motif chemokine 3G0/G1 switch regulatory protein 19-1PAT 464.1SIS-betachemokine (C-C motif) ligand 3macrophage inflammatory protein 1-alphasmall inducible cytokine A3 (homologous to mouse Mip-1a)tonsillar lymphocyte LD78 alpha protein
Modification date2018052320180523
UniProtAcc

O43572

P10147

Ensembl transtripts involved in fusion geneENST00000225737, ENST00000395536, 
ENST00000572155, 
ENST00000225245, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: AKAP10 [Title/Abstract] AND CCL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCL3

GO:0001775

cell activation

10706735

TgeneCCL3

GO:0002548

monocyte chemotaxis

10706735

TgeneCCL3

GO:0006816

calcium ion transport

10734056

TgeneCCL3

GO:0006874

cellular calcium ion homeostasis

10072545|10734056|21403648

TgeneCCL3

GO:0006887

exocytosis

10734056

TgeneCCL3

GO:0006935

chemotaxis

10679098

TgeneCCL3

GO:0006954

inflammatory response

10679098|10706735|21147091

TgeneCCL3

GO:0007010

cytoskeleton organization

10072545

TgeneCCL3

GO:0007267

cell-cell signaling

10679098

TgeneCCL3

GO:0008360

regulation of cell shape

10072545

TgeneCCL3

GO:0009636

response to toxic substance

10841574

TgeneCCL3

GO:0010628

positive regulation of gene expression

10706735

TgeneCCL3

GO:0010629

negative regulation of gene expression

21403648

TgeneCCL3

GO:0010818

T cell chemotaxis

10706735

TgeneCCL3

GO:0014808

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

19523456

TgeneCCL3

GO:0019722

calcium-mediated signaling

10072545|19523456

TgeneCCL3

GO:0030335

positive regulation of cell migration

7545673|10706735

TgeneCCL3

GO:0030502

negative regulation of bone mineralization

21403648

TgeneCCL3

GO:0030593

neutrophil chemotaxis

10706735

TgeneCCL3

GO:0031663

lipopolysaccharide-mediated signaling pathway

21147091

TgeneCCL3

GO:0043308

eosinophil degranulation

10706735

TgeneCCL3

GO:0043922

negative regulation by host of viral transcription

10841574

TgeneCCL3

GO:0045671

negative regulation of osteoclast differentiation

21403648

TgeneCCL3

GO:0048245

eosinophil chemotaxis

10072545

TgeneCCL3

GO:0048247

lymphocyte chemotaxis

10706735

TgeneCCL3

GO:0050795

regulation of behavior

20167378

TgeneCCL3

GO:0051928

positive regulation of calcium ion transport

8699119|15764707

TgeneCCL3

GO:0051930

regulation of sensory perception of pain

15764707

TgeneCCL3

GO:0070374

positive regulation of ERK1 and ERK2 cascade

21403648

TgeneCCL3

GO:0070723

response to cholesterol

19523456

TgeneCCL3

GO:0071407

cellular response to organic cyclic compound

21147091

TgeneCCL3

GO:0071621

granulocyte chemotaxis

10706735

TgeneCCL3

GO:2000503

positive regulation of natural killer cell chemotaxis

7545673


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-FX-A3TO-01AAKAP10chr17

19880905

-CCL3chr17

34416643

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000225737ENST00000225245AKAP10chr17

19880905

-CCL3chr17

34416643

-
Frame-shiftENST00000395536ENST00000225245AKAP10chr17

19880905

-CCL3chr17

34416643

-
intron-3CDSENST00000572155ENST00000225245AKAP10chr17

19880905

-CCL3chr17

34416643

-

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FusionProtFeatures for AKAP10_CCL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP10

O43572

CCL3

P10147

Differentially targeted protein that binds to type I andII regulatory subunits of protein kinase A and anchors them to themitochondria or the plasma membrane. Although the physiologicalrelevance between PKA and AKAPS with mitochondria is not fullyunderstood, one idea is that BAD, a proapoptotic member, isphosphorylated and inactivated by mitochondria-anchored PKA. Itcannot be excluded too that it may facilitate PKA as well as Gprotein signal transduction, by acting as an adapter forassembling multiprotein complexes. With its RGS domain, it couldlead to the interaction to G-alpha proteins, providing a linkbetween the signaling machinery and the downstream kinase (Bysimilarity). {ECO:0000250}. Monokine with inflammatory and chemokinetic properties.Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressivefactors produced by CD8+ T-cells. Recombinant MIP-1-alpha inducesa dose-dependent inhibition of different strains of HIV-1, HIV-2,and simian immunodeficiency virus (SIV).{ECO:0000269|PubMed:8525373}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AKAP10_CCL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AKAP10_CCL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AKAP10PRKAR1A, PDZK1, HAX1, COG3, DCTN4, MYH9, TRIM25CCL3CCR5, CCL3, CCL4, CCR4, ZFP36


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AKAP10_CCL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AKAP10_CCL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP10C0005586Bipolar Disorder1PSYGENET
TgeneCCL3C0007786Brain Ischemia2CTD_human
TgeneCCL3C0020517Hypersensitivity2CTD_human
TgeneCCL3C0034069Pulmonary Fibrosis2CTD_human
TgeneCCL3C0004153Atherosclerosis1CTD_human
TgeneCCL3C0017658Glomerulonephritis1CTD_human
TgeneCCL3C0021368Inflammation1CTD_human
TgeneCCL3C0035126Reperfusion Injury1CTD_human
TgeneCCL3C0038220Status Epilepticus1CTD_human
TgeneCCL3C0151744Myocardial Ischemia1CTD_human
TgeneCCL3C0273115Lung Injury1CTD_human
TgeneCCL3C0345967Malignant mesothelioma1CTD_human
TgeneCCL3C2239176Liver carcinoma1CTD_human