FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12986

FusionGeneSummary for FAT1_SORBS2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAT1_SORBS2
Fusion gene ID: 12986
HgeneTgene
Gene symbol

FAT1

SORBS2

Gene ID

2195

8470

Gene nameFAT atypical cadherin 1sorbin and SH3 domain containing 2
SynonymsCDHF7|CDHR8|FAT|ME5|hFat1ARGBP2|PRO0618
Cytomap

4q35.2

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homologsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2
Modification date2018051920180523
UniProtAcc

Q14517

O94875

Ensembl transtripts involved in fusion geneENST00000441802, ENST00000512347, 
ENST00000448662, ENST00000431808, 
ENST00000284776, ENST00000437304, 
ENST00000319471, ENST00000449407, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000498125, 
Fusion gene scores* DoF score10 X 10 X 7=70011 X 12 X 7=924
# samples 1315
** MAII scorelog2(13/700*10)=-2.42884329880387
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/924*10)=-2.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAT1 [Title/Abstract] AND SORBS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-EA-A5ZE-01AFAT1chr4

187524057

-SORBS2chr4

186696520

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000441802ENST00000448662FAT1chr4

187524057

-SORBS2chr4

186696520

-
5CDS-5UTRENST00000441802ENST00000431808FAT1chr4

187524057

-SORBS2chr4

186696520

-
5CDS-5UTRENST00000441802ENST00000284776FAT1chr4

187524057

-SORBS2chr4

186696520

-
5CDS-5UTRENST00000441802ENST00000437304FAT1chr4

187524057

-SORBS2chr4

186696520

-
5CDS-5UTRENST00000441802ENST00000319471FAT1chr4

187524057

-SORBS2chr4

186696520

-
5CDS-5UTRENST00000441802ENST00000449407FAT1chr4

187524057

-SORBS2chr4

186696520

-
5CDS-5UTRENST00000441802ENST00000355634FAT1chr4

187524057

-SORBS2chr4

186696520

-
5CDS-5UTRENST00000441802ENST00000393528FAT1chr4

187524057

-SORBS2chr4

186696520

-
5CDS-intronENST00000441802ENST00000418609FAT1chr4

187524057

-SORBS2chr4

186696520

-
5CDS-intronENST00000441802ENST00000498125FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-intronENST00000512347ENST00000448662FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-5UTRENST00000512347ENST00000431808FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-5UTRENST00000512347ENST00000284776FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-5UTRENST00000512347ENST00000437304FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-5UTRENST00000512347ENST00000319471FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-5UTRENST00000512347ENST00000449407FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-5UTRENST00000512347ENST00000355634FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-5UTRENST00000512347ENST00000393528FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-intronENST00000512347ENST00000418609FAT1chr4

187524057

-SORBS2chr4

186696520

-
intron-intronENST00000512347ENST00000498125FAT1chr4

187524057

-SORBS2chr4

186696520

-

Top

FusionProtFeatures for FAT1_SORBS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAT1

Q14517

SORBS2

O94875

Plays an essential role for cellular polarization,directed cell migration and modulating cell-cell contact.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAT1_SORBS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAT1_SORBS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAT1HDAC6, NUB1, UBC, NOS2, VASP, AIRE, ILK, RPS6KA2, KLK11, TAZ, NXPH2, TRAC, SUSD4, DNASE2B, CALR3, VEGFB, CD96, LIPH, GPHA2, C2orf48, CLK1, EZH2, NIPSNAP1, SH3RF1, TRAF4, NOXA1, ND1, SORBS2, IGLL1, PSG8, XAGE1B, PDGFB, SLAMF1, GML, IFNE, DKKL1, SIRT6, BRINP3, ST8SIA4SORBS2YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAT1_SORBS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAT1_SORBS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAT1C0009404Colorectal Neoplasms1CTD_human
HgeneFAT1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneFAT1C0017636Glioblastoma1CTD_human
HgeneFAT1C0018671Head and Neck Neoplasms1CTD_human
HgeneFAT1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFAT1C0036095Salivary Gland Neoplasms1CTD_human
HgeneFAT1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneSORBS2C0043094Weight Gain1CTD_human