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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1298

FusionGeneSummary for AK9_PDSS2

check button Fusion gene summary
Fusion gene informationFusion gene name: AK9_PDSS2
Fusion gene ID: 1298
HgeneTgene
Gene symbol

AK9

PDSS2

Gene ID

221264

57107

Gene nameadenylate kinase 9decaprenyl diphosphate synthase subunit 2
SynonymsAK 9|AKD1|AKD2|C6orf199|C6orf224|dJ70A9.1C6orf210|COQ10D3|DLP1|bA59I9.3|hDLP1
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
Descriptionadenylate kinase 9adenylate kinase domain containing 1adenylate kinase domain containing 2decaprenyl-diphosphate synthase subunit 2all-trans-decaprenyl-diphosphate synthase subunit 2decaprenyl pyrophosphate synthase subunit 2decaprenyl pyrophosphate synthetase subunit 2prenyl (decaprenyl) diphosphate synthase, subunit 2subunit 2 of decapr
Modification date2018051920180527
UniProtAcc

Q5TCS8

Q86YH6

Ensembl transtripts involved in fusion geneENST00000424296, ENST00000341338, 
ENST00000368948, ENST00000285397, 
ENST00000355283, 
ENST00000369037, 
ENST00000453874, ENST00000369031, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 5 X 6=210
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AK9 [Title/Abstract] AND PDSS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAK9

GO:0006174

dADP phosphorylation

23416111

HgeneAK9

GO:0006186

dGDP phosphorylation

23416111

HgeneAK9

GO:0006756

AMP phosphorylation

23416111

HgeneAK9

GO:0006757

ATP generation from ADP

23416111

HgeneAK9

GO:0061508

CDP phosphorylation

23416111

HgeneAK9

GO:0061565

dAMP phosphorylation

23416111

HgeneAK9

GO:0061566

CMP phosphorylation

23416111

HgeneAK9

GO:0061567

dCMP phosphorylation

23416111

HgeneAK9

GO:0061568

GDP phosphorylation

23416111

HgeneAK9

GO:0061569

UDP phosphorylation

23416111

HgeneAK9

GO:0061570

dCDP phosphorylation

23416111

HgeneAK9

GO:0061571

TDP phosphorylation

23416111

TgenePDSS2

GO:0006744

ubiquinone biosynthetic process

16262699

TgenePDSS2

GO:0008299

isoprenoid biosynthetic process

16262699


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0800-01AAK9chr6

110011675

-PDSS2chr6

107595431

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000424296ENST00000369037AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000424296ENST00000453874AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000424296ENST00000369031AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000341338ENST00000369037AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000341338ENST00000453874AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000341338ENST00000369031AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000368948ENST00000369037AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000368948ENST00000453874AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000368948ENST00000369031AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000285397ENST00000369037AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000285397ENST00000453874AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000285397ENST00000369031AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000355283ENST00000369037AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000355283ENST00000453874AK9chr6

110011675

-PDSS2chr6

107595431

-
intron-3CDSENST00000355283ENST00000369031AK9chr6

110011675

-PDSS2chr6

107595431

-

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FusionProtFeatures for AK9_PDSS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AK9

Q5TCS8

PDSS2

Q86YH6

Supplies decaprenyl diphosphate, the precursor for theside chain of the isoprenoid quinones ubiquinone-10.{ECO:0000269|PubMed:16262699}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AK9_PDSS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AK9_PDSS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AK9CUL4A, HSP90B1, RHOA, LRRC23, EXOG, C5orf34, HDAC3, TAF2, MYO9A, PRIM1PDSS2ELAVL1, APP, OXLD1, ACAD9, SDHA, THEM4, FDPS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AK9_PDSS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AK9_PDSS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDSS2C3553358COENZYME Q10 DEFICIENCY, PRIMARY, 31UNIPROT