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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12977

FusionGeneSummary for FASTK_GNGT1

check button Fusion gene summary
Fusion gene informationFusion gene name: FASTK_GNGT1
Fusion gene ID: 12977
HgeneTgene
Gene symbol

FASTK

GNGT1

Gene ID

10922

2792

Gene nameFas activated serine/threonine kinaseG protein subunit gamma transducin 1
SynonymsFASTGNG1
Cytomap

7q36.1

7q21.3

Type of geneprotein-codingprotein-coding
Descriptionfas-activated serine/threonine kinaseFAST kinaseguanine nucleotide-binding protein G(T) subunit gamma-T1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1transducin gamma chain
Modification date2018051920180523
UniProtAcc

Q14296

P63211

Ensembl transtripts involved in fusion geneENST00000489884, ENST00000540185, 
ENST00000353841, ENST00000297532, 
ENST00000482571, 		ENST00000455502, 
ENST00000248572, ENST00000429473, 
ENST00000430875, ENST00000428834, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 3=108
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FASTK [Title/Abstract] AND GNGT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFASTK

GO:0006468

protein phosphorylation

7544399

HgeneFASTK

GO:0043484

regulation of RNA splicing

17135269


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-S9-A89Z-01AFASTKchr7

150774397

-GNGT1chr7

93540102

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000489884ENST00000455502FASTKchr7

150774397

-GNGT1chr7

93540102

+
5UTR-3UTRENST00000489884ENST00000248572FASTKchr7

150774397

-GNGT1chr7

93540102

+
5UTR-3UTRENST00000489884ENST00000429473FASTKchr7

150774397

-GNGT1chr7

93540102

+
5UTR-intronENST00000489884ENST00000430875FASTKchr7

150774397

-GNGT1chr7

93540102

+
5UTR-intronENST00000489884ENST00000428834FASTKchr7

150774397

-GNGT1chr7

93540102

+
intron-3UTRENST00000540185ENST00000455502FASTKchr7

150774397

-GNGT1chr7

93540102

+
intron-3UTRENST00000540185ENST00000248572FASTKchr7

150774397

-GNGT1chr7

93540102

+
intron-3UTRENST00000540185ENST00000429473FASTKchr7

150774397

-GNGT1chr7

93540102

+
intron-intronENST00000540185ENST00000430875FASTKchr7

150774397

-GNGT1chr7

93540102

+
intron-intronENST00000540185ENST00000428834FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-3UTRENST00000353841ENST00000455502FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-3UTRENST00000353841ENST00000248572FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-3UTRENST00000353841ENST00000429473FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-intronENST00000353841ENST00000430875FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-intronENST00000353841ENST00000428834FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-3UTRENST00000297532ENST00000455502FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-3UTRENST00000297532ENST00000248572FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-3UTRENST00000297532ENST00000429473FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-intronENST00000297532ENST00000430875FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-intronENST00000297532ENST00000428834FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-3UTRENST00000482571ENST00000455502FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-3UTRENST00000482571ENST00000248572FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-3UTRENST00000482571ENST00000429473FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-intronENST00000482571ENST00000430875FASTKchr7

150774397

-GNGT1chr7

93540102

+
5CDS-intronENST00000482571ENST00000428834FASTKchr7

150774397

-GNGT1chr7

93540102

+

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FusionProtFeatures for FASTK_GNGT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FASTK

Q14296

GNGT1

P63211

Phosphorylates the splicing regulator TIA1, therebypromoting the inclusion of FAS exon 6, which leads to an mRNAencoding a pro-apoptotic form of the receptor.{ECO:0000269|PubMed:17135269, ECO:0000269|PubMed:7544399}. Isoform 4: Required for the biogenesis of somemitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADHdehydrogenase complex subunit 6) mRNA, and regulates its levels.{ECO:0000269|PubMed:25704814}. Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FASTK_GNGT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FASTK_GNGT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FASTKMDFI, RBPMS, CALCOCO2, TIA1, HSP90AA1, WIPF1, HNRNPH2, TRIM25GNGT1GNB1, GNB2, IKBKG, GNB4, ZNF277, PDCL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FASTK_GNGT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FASTK_GNGT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource