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Fusion gene ID: 12959 |
FusionGeneSummary for FARS2_LYRM4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FARS2_LYRM4 | Fusion gene ID: 12959 | Hgene | Tgene | Gene symbol | FARS2 | LYRM4 | Gene ID | 10667 | 57128 |
| Gene name | phenylalanyl-tRNA synthetase 2, mitochondrial | LYR motif containing 4 | |
| Synonyms | COXPD14|FARS1|HSPC320|PheRS|SPG77 | C6orf149|CGI-203|COXPD19|ISD11 | |
| Cytomap | 6p25.1 | 6p25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phenylalanine--tRNA ligase, mitochondrialdJ236A3.1 (phenylalanine-tRNA synthetase)dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase))mitochondrial PHERSphenylalanine tRNA ligase 2, mitochondrialphenylalanine translasephenylalanine-tRNA synthetase 1 ( | LYR motif-containing protein 4homolog of yeast Isd11mitochondrial matrix Nfs1 interacting protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O95363 | Q9HD34 | |
| Ensembl transtripts involved in fusion gene | ENST00000324331, ENST00000274680, | ENST00000330636, ENST00000468929, ENST00000464010, ENST00000480566, ENST00000500576, ENST00000606472, | |
| Fusion gene scores | * DoF score | 13 X 7 X 10=910 | 7 X 2 X 4=56 |
| # samples | 14 | 7 | |
| ** MAII score | log2(14/910*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/56*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FARS2 [Title/Abstract] AND LYRM4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FARS2 | GO:0006432 | phenylalanyl-tRNA aminoacylation | 10329163 |
| Hgene | FARS2 | GO:0008033 | tRNA processing | 10329163 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D3-A2J9-06A | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000324331 | ENST00000330636 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000324331 | ENST00000468929 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000324331 | ENST00000464010 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000324331 | ENST00000480566 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000324331 | ENST00000500576 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000324331 | ENST00000606472 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| In-frame | ENST00000274680 | ENST00000330636 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000274680 | ENST00000468929 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000274680 | ENST00000464010 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000274680 | ENST00000480566 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000274680 | ENST00000500576 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
| 5CDS-intron | ENST00000274680 | ENST00000606472 | FARS2 | chr6 | 5613553 | + | LYRM4 | chr6 | 5216971 | - |
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FusionProtFeatures for FARS2_LYRM4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FARS2 | LYRM4 |
| Is responsible for the charging of tRNA(Phe) withphenylalanine in mitochondrial translation. To a lesser extent,also catalyzes direct attachment of m-Tyr (an oxidized version ofPhe) to tRNA(Phe), thereby opening the way for delivery of themisacylated tRNA to the ribosome and incorporation of ROS-damagedamino acid into proteins. {ECO:0000269|PubMed:19549855,ECO:0000269|PubMed:22833457}. | Required for nuclear and mitochondrial iron-sulfurprotein biosynthesis. {ECO:0000269|PubMed:17331979,ECO:0000269|PubMed:19454487}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FARS2 | chr6:5613553 | chr6:5216971 | ENST00000274680 | + | 6 | 7 | 157_160 | 405 | 452 | Region | Note=Substrate binding |
| Hgene | FARS2 | chr6:5613553 | chr6:5216971 | ENST00000274680 | + | 6 | 7 | 186_188 | 405 | 452 | Region | Note=Substrate binding |
| Hgene | FARS2 | chr6:5613553 | chr6:5216971 | ENST00000274680 | + | 6 | 7 | 193_195 | 405 | 452 | Region | Note=Substrate binding |
| Hgene | FARS2 | chr6:5613553 | chr6:5216971 | ENST00000324331 | + | 6 | 7 | 157_160 | 405 | 452 | Region | Note=Substrate binding |
| Hgene | FARS2 | chr6:5613553 | chr6:5216971 | ENST00000324331 | + | 6 | 7 | 186_188 | 405 | 452 | Region | Note=Substrate binding |
| Hgene | FARS2 | chr6:5613553 | chr6:5216971 | ENST00000324331 | + | 6 | 7 | 193_195 | 405 | 452 | Region | Note=Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FARS2 | chr6:5613553 | chr6:5216971 | ENST00000274680 | + | 6 | 7 | 358_450 | 405 | 452 | Domain | FDX-ACB |
| Hgene | >FARS2 | chr6:5613553 | chr6:5216971 | ENST00000324331 | + | 6 | 7 | 358_450 | 405 | 452 | Domain | FDX-ACB |
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FusionGeneSequence for FARS2_LYRM4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FARS2_ENST00000324331_chr6_5613553_+_LYRM4_ENST00000330636_chr6_5216971_-_469aa MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIK ERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPF THPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQVHIG >In-frame_FARS2_ENST00000274680_chr6_5613553_+_LYRM4_ENST00000330636_chr6_5216971_-_469aa MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIK ERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPF THPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQVHIG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FARS2_ENST00000324331_chr6_5613553_+_LYRM4_ENST00000330636_chr6_5216971_-_1407nt ATGGTGGGCTCAGCTCTCAGGAGAGGTGCCCATGCATATGTCTACCTGGTGAGTAAGGCCAGTCACATCTCCAGAGGCCATCAGCACCAG GCCTGGGGATCGAGGCCTCCTGCAGCAGAGTGTGCCACCCAAAGAGCTCCAGGCAGTGTGGTGGAGCTGCTGGGCAAATCCTACCCTCAG GACGACCACAGCAACCTCACCCGGAAGGTCCTCACCAGAGTTGGCAGGAACCTGCACAACCAGCAGCATCACCCTCTGTGGCTGATCAAG GAGAGGGTGAAGGAGCACTTCTACAAGCAGTATGTGGGCCGCTTTGGGACCCCGTTGTTCTCGGTCTACGACAACCTTTCTCCAGTGGTC ACGACCTGGCAGAACTTTGACAGCCTGCTCATCCCAGCTGATCACCCCAGCAGGAAGAAGGGGGACAACTATTACCTGAATCGGACTCAC ATGCTGAGAGCGCACACGTCTGCACACCAGTGGGACTTGCTGCACGCGGGACTGGATGCCTTCCTGGTGGTGGGTGATGTCTACAGGCGT GACCAGATCGACTCCCAGCACTACCCTATTTTCCACCAGCTGGAGGCCGTGCGGCTCTTCTCCAAGCATGAGTTATTTGCTGGTATAAAG GATGGAGAAAGCCTGCAGCTCTTTGAACAAAGTTCTCGCTCTGCGCATAAACAAGAGACACACACCATGGAGGCCGTGAAGCTTGTAGAG TTTGATCTTAAGCAAACGCTTACCAGGCTCATGGCACATCTTTTTGGAGATGAGCTGGAGATAAGATGGGTAGACTGCTACTTCCCTTTT ACACATCCTTCCTTTGAGATGGAGATCAACTTTCATGGAGAATGGCTGGAAGTTCTTGGCTGCGGGGTGATGGAACAACAACTGGTCAAT TCAGCTGGTGCTCAAGACCGAATCGGCTGGGCTTTTGGCCTAGGATTAGAAAGGCTAGCCATGATCCTCTACGACATCCCTGATATCCGT CTCTTCTGGTGTGAGGACGAGCGCTTCCTGAAGCAGTTCTGTGTATCCAACATTAATCAGAAGGTGAAGTTTCAGCCTCTTAGCAAATAT CCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGA GACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAAT AAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGGTCCACATTGGC >In-frame_FARS2_ENST00000274680_chr6_5613553_+_LYRM4_ENST00000330636_chr6_5216971_-_1407nt ATGGTGGGCTCAGCTCTCAGGAGAGGTGCCCATGCATATGTCTACCTGGTGAGTAAGGCCAGTCACATCTCCAGAGGCCATCAGCACCAG GCCTGGGGATCGAGGCCTCCTGCAGCAGAGTGTGCCACCCAAAGAGCTCCAGGCAGTGTGGTGGAGCTGCTGGGCAAATCCTACCCTCAG GACGACCACAGCAACCTCACCCGGAAGGTCCTCACCAGAGTTGGCAGGAACCTGCACAACCAGCAGCATCACCCTCTGTGGCTGATCAAG GAGAGGGTGAAGGAGCACTTCTACAAGCAGTATGTGGGCCGCTTTGGGACCCCGTTGTTCTCGGTCTACGACAACCTTTCTCCAGTGGTC ACGACCTGGCAGAACTTTGACAGCCTGCTCATCCCAGCTGATCACCCCAGCAGGAAGAAGGGGGACAACTATTACCTGAATCGGACTCAC ATGCTGAGAGCGCACACGTCTGCACACCAGTGGGACTTGCTGCACGCGGGACTGGATGCCTTCCTGGTGGTGGGTGATGTCTACAGGCGT GACCAGATCGACTCCCAGCACTACCCTATTTTCCACCAGCTGGAGGCCGTGCGGCTCTTCTCCAAGCATGAGTTATTTGCTGGTATAAAG GATGGAGAAAGCCTGCAGCTCTTTGAACAAAGTTCTCGCTCTGCGCATAAACAAGAGACACACACCATGGAGGCCGTGAAGCTTGTAGAG TTTGATCTTAAGCAAACGCTTACCAGGCTCATGGCACATCTTTTTGGAGATGAGCTGGAGATAAGATGGGTAGACTGCTACTTCCCTTTT ACACATCCTTCCTTTGAGATGGAGATCAACTTTCATGGAGAATGGCTGGAAGTTCTTGGCTGCGGGGTGATGGAACAACAACTGGTCAAT TCAGCTGGTGCTCAAGACCGAATCGGCTGGGCTTTTGGCCTAGGATTAGAAAGGCTAGCCATGATCCTCTACGACATCCCTGATATCCGT CTCTTCTGGTGTGAGGACGAGCGCTTCCTGAAGCAGTTCTGTGTATCCAACATTAATCAGAAGGTGAAGTTTCAGCCTCTTAGCAAATAT CCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGA GACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAAT AAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGGTCCACATTGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FARS2_ENST00000324331_chr6_5613553_+_LYRM4_ENST00000330636_chr6_5216971_-_8573nt ACGCGGCGGGAGGGCGGGGAAATAAGAGGACTGGCCGCCCGTGCATCCAGCCAAGCTCCTGGCGGACGGATATCGGAGGCCCAGGCATTC GAGGGACGTGCAGTTGCATCACGGAGAGCCTTTGGGAACCGTCTGGGGTCTTGGCGGAGACATTTGTGTTTCGGGGGCAGCGCCCCTTCC TACATCCAGGAGGCCGCGTTGCCCGGGTTACCGAAGGCCGCCGCACCGACGCCCCGCCCCTGACCGCCGATGCCCCTCCCACGCCGGCTG CGGTCGCCCTCGGCGCTGCCTGAGAGAGTTTGCGGGATTTCAAGGAACCTGTGAGAAGTTTCTACAATGGTGGGCTCAGCTCTCAGGAGA GGTGCCCATGCATATGTCTACCTGGTGAGTAAGGCCAGTCACATCTCCAGAGGCCATCAGCACCAGGCCTGGGGATCGAGGCCTCCTGCA GCAGAGTGTGCCACCCAAAGAGCTCCAGGCAGTGTGGTGGAGCTGCTGGGCAAATCCTACCCTCAGGACGACCACAGCAACCTCACCCGG AAGGTCCTCACCAGAGTTGGCAGGAACCTGCACAACCAGCAGCATCACCCTCTGTGGCTGATCAAGGAGAGGGTGAAGGAGCACTTCTAC AAGCAGTATGTGGGCCGCTTTGGGACCCCGTTGTTCTCGGTCTACGACAACCTTTCTCCAGTGGTCACGACCTGGCAGAACTTTGACAGC CTGCTCATCCCAGCTGATCACCCCAGCAGGAAGAAGGGGGACAACTATTACCTGAATCGGACTCACATGCTGAGAGCGCACACGTCTGCA CACCAGTGGGACTTGCTGCACGCGGGACTGGATGCCTTCCTGGTGGTGGGTGATGTCTACAGGCGTGACCAGATCGACTCCCAGCACTAC CCTATTTTCCACCAGCTGGAGGCCGTGCGGCTCTTCTCCAAGCATGAGTTATTTGCTGGTATAAAGGATGGAGAAAGCCTGCAGCTCTTT GAACAAAGTTCTCGCTCTGCGCATAAACAAGAGACACACACCATGGAGGCCGTGAAGCTTGTAGAGTTTGATCTTAAGCAAACGCTTACC AGGCTCATGGCACATCTTTTTGGAGATGAGCTGGAGATAAGATGGGTAGACTGCTACTTCCCTTTTACACATCCTTCCTTTGAGATGGAG ATCAACTTTCATGGAGAATGGCTGGAAGTTCTTGGCTGCGGGGTGATGGAACAACAACTGGTCAATTCAGCTGGTGCTCAAGACCGAATC GGCTGGGCTTTTGGCCTAGGATTAGAAAGGCTAGCCATGATCCTCTACGACATCCCTGATATCCGTCTCTTCTGGTGTGAGGACGAGCGC TTCCTGAAGCAGTTCTGTGTATCCAACATTAATCAGAAGGTGAAGTTTCAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCA TTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTC ATAGACAAGTTTGTACATCCAAAAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAA ATTCAAACCCTAGTGAATAAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGGTCCACATTGGCCAACTGTATTCAACTGACAAGCTG ATCATTGAGAATCGAGACATGCCCAGGACCTAGCAAGCCGGGGACCAGCCACCAGTGGCGGCCAGGGACCACCTTCAGCATCCACTCTCT GTTTGAGATGGGGGCTCCCAAAACCAGCTTACAATAGCCTTTTGCGCTGCCTGTCCTGTGGGAGCTGATAAACCAAGTCACATTTGCATT CTGTTGCAGGCTTAGTGAAAAAGGACTGCTGTCTTTCCTTGGTTCAAGTGTTAGAATGGAGAGCTGGAGTTCGTTCAGAATAGTGCTGTG TGTTACCACGTCTCCCCTGCACCCCATTCCTACCTTGTAGCTCATGACCATTGTGTATAGCATTTCTACACTTTGTTTCTTGGTCCTTGG CAATAAAAAGAATGATCTCCCTGAGCCTTTGACCCCAGATAAACCCCTCCCAATTAATGCATTTTCATTTCCTACTGATACAAGGCCTGG AGAGGGCTGTTGGGGGCCCTCAGGGAGGGTTCAACTCTGAGACGAGAACTGCCTTGGTGAAGGCAAGTTCAAGCACCACTTGAGACTGGG GGCAGCATGGAGTAGGGCAGGGCTACGGGGATACACGGTGCACCCTGCAACTTATACCTGAGCCCAGTACAACAAAGGTGACGGGTGTGT AGGTACACACCCAGAGATGGAGCACTGCAGATCAGCAACCTCAGCCCCACCTGGGAATTTGCTGGAAATGCAGGCTCAAGCCCCTCCCCA CACCTGGTGAATGAGAGAGCCCCAGCCTGACCCAAGCCCAGGGCGACTCCCATACCCTGAAGCCTGGGGCATGCTGGGCAGCACCGGTGC CCAAATCTGGCTGGTGGACAGAAGCACCTGGAGAGTTGGAGAGCTTTTTAAAAAGACATCTCTCAGCACTTCCCTCTCTGCAGATTCTGA CTCAGTAAGTGAGGGGTGAGGCACAGTCATTTTTCTCTATTCTGAAGCTCTCCCACTGTTTTCAATGTTTAACCAACTGGGGACCCCTGC TCTTTAAGTATATTACAGGTAATAAAGATATTGTTTGTATGCTTTTATTCTTGGAAACAGATTCATTCCAAACATAGAAAGAACATATTA AATAACTTGCTTGTCATCTGGGGAGTTTACGAGGGACCAGACCTGGCAGAGCGGTTTCTTGTTTCCCTTTGCATACAGTGCTCAGTGGAT TTGGTATCTGTGGGTTAAGGTTTGGAACAGGCTCCTATAAATAGCACCGGTCCTGGAATAGCTGCAGCACTGTCACCCCCTCATTTTAAC TCCGACGGTCATGGGAGTGAGTACGCACTGTCTGAGCCCGTGTTCTTCTCACCCTCATATGAGAACTCATGTCTTCCAGTCGCTTTTAGA GAGCATAGATTTGCTGCAATGATGCGTTCAAATAGATGTAACGTGTAGCCATTCTATTTGGCAGTACAACTTTTGATTTCAGGATAAAGT CTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGCGGTGCGATCTTGGCTCACTGCAACCTCCACCTCCTGGGTT CAAGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGGGCCTGCCACCACGCCCAGCTAATTTTTTGTATTTTTAATAGAG ACGGGGTTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTCGGCCCCCCAAAGTGCTGGTATTACAGGCATGAACCACCACCCCCTGCC AATTTCAGGATAAAGTCCTGAGCATCTGTGAAAATAATGAAGCTCTTAGCAAGTCCCAGATCTCTTACCCTCTAACCAGTTCCTGCCTGG GAGCTGCAGTGTTAGAGCATATGCAAAGCCCTAATTGGGGGAGAGCTGTTCGGTGGACAGTGAACGGAGGTGATGTGGCAAGTATAATCA CTCCCTTCAGCTGACTGTCACGGGGCAGAGCCGCCCAGCCCAGCCCTGTGTGTGGCTCTGGCTCAGGTTTTCCACCTTGCATCAGTGCAG TGGAGTTCGTGGTCACTCAGCAGTGAATGCATCCAACCACGCTACTAACGCACGGCACTGCTGATTTATACTTAATTTAAGCAACTGCTA CTTGGAACCGAAGTCCAGATTTGAACCTCCGTGCTGAAGGCATCAAATTGCCGGCAAGATAACAGCTCCAGAGGAGACTTCTCCCACTCC CCCAGGTTTTACGCAATGAGGCAGTCCACCCAAACTTAACGTGGGCTGCAGGCTGTAACAGCAGGTTGCTTTTGTGTTCATTAAACTGCA TGAATGGGTTTGAACATGCCCAAAGCCTTGCTAATGCAGACTTAATTTTGTAAAATTAACTATGCCTTTGGAATCTGCAGAAAGATACAA ATCCGAATTCTGTGGCAGGAAACGCCACAAACAGGCCTTGGTCCTCCACCTTTCAGGTGTATATCTGGCAGGCAGAGCCTGGCACTGGGT ACTCCCCAACTGAGATGACCCAATATTGATGCTAGAGCTTCGAATAAAGTGGCATTCCCATGGGGGTGACCCCTGGTGTTTCTCTAGGGA AGTATTCCACCTCCTTGACTATGCACCAACTGAGGGGAATGTGGGCAACTCCAACATCCATCATGGCCAGCCTCACAGAACTCTCTAGAA CTTGTGCCTGCTTTGAAGATAGGATCCGGGCTGGGGTCTGGAGATCACTTTGCAGCACTAATATTGAGCAAATGAGAACTACTATCATTA GTTAACTTCCCAGGCAGAACTCATTGGCCGAGCAAGGCTATATCCTAGACTTTCAGAGACAGCTCTGGGCTGGGCTGGCTGTCATGACAT AATAGCTGGGAGATCTTGCACGGCCAAGTACAGGGCTGTGTTGTTCTGATGGCTGTTGGAATCTGGATTTTGGAACTGAAAGAATTGGCT AGATTGCTTTAGGTATACTCCGTCCTGCTGCTAACTAAGTAGCAGTGACCTTTAACTCCCTTCATCCACAGCCTCTCCCGTTAATCTCAA GCCCCACCATACAACCCACCATCATCCAGGAGCAAAAGGGACAGGCAGAGGGTGAAGCCTACAAAGATGACAAACATCAGAGCTCACCTA GTCCAACCCTCAAATCTTCAGGTGTTAAAACAAAGAGCCTGAACATCTGCAGATCACGTACAGAGTCAGGGCCTTTCCCCTAAACCCCTT TCACTCATTCATTTATTCACTCAGTATTGACTAAGGCCACCTAGTGCCAGGTGCCAGGTGCCAGGGAGCAACCAGTGAACAAGACAGACG TACCTTCATAAAGCCTGTGTCTAGCAGGGAAATCTGAGAAGAAAATGACAAGTCTTATGAATGTTACAAAGAGGGAAATATGAGTGCTGC CAGAGCCGATGGGACGGGCCAGGGAAGGGCTCCCCAGGGGATATTTACACGTGCAAATTAATGATGAGGATTGGCTGTGTGAAGGTGGGG AGAGGAGCTCTCTAGGCAGGAGGAACAGCACATGCAAAGCCCTTAATTGGGGGAGAGGGTAGTTCCATGCAAAGAACTAAAGGGAGTCTG GGATGGTGGCAGCCAAGGAAGAGGGCTCTTTCCACATCGTGGACGGCCTTGGAGCCTCAGCCTAAGGATGGTGAGCAACTCGGGAGTTTT TAGGCAAGATGAGGTTTTTGTTTTGTTTTGTTTTGTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATAAT CTCAGCTCACTACAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCACGCCACCA TGCCCAGCTAAGTTTTATATTTTTTAGTAGACACAGGATTTCGCCATGTTGGCCAGGCTGCTCTTGAACTCCTGACCCCAGATGATCCGC CTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCCCCCGACCGAAGTTTGTATTTTTTAAAAGGTCACATTGTCTGC TTTTGAGGGGATACACTGGGAGAGATGCAGGGAGACCAGCTTTTCGGAGGAGTGGGGGATTGGGTGTGGCATTCCAGGCAAGCGATGGTG ACTTCACCAAGAGGCAACAGCTGAACAGAAGCAGAGTCAGCATCACCCTGAGAACTGGCTGGGGTGGGCCGCCATTGAAGGAGGACAGGA AACCTGGAGCAGAGCTGCCCCAGCTGAGCACAGCCCGAGCTCCCCAGCCCACCTGCCGATGCGCGAGAAAGTCCACAGAGTCCCCTAGCC TGGTCTAGCTTAGGTCAGTCATATTCAGCCACCCCTCAGACATGTGCTAAATAATTAACTGTTACATTAGTCACTGAGTTTGGAGGTAGA TTATTATGAAGTAACAGCAAACTAATACAGAGAGCATCTCTGTATTAATGTATTAATGTATTACTTTCTCAGGGCCACATAGCAAACCAA AGAGTAGGCAGACAAACGGCCAAAACTGCAGGTCTCCTGTATGGGGACATTTCCACAAATATCTTCAGAATACTGGTCACTCCCTTTAGA GAACAAGTCCTGGAGAAACAGTCGAAACAGTCATCACGTGTCCTACAGATGGAAGGGCTGGCCAACCAGAAAGAAAAGAAAAAGTCGAGT CAGCAGAACTTGGTGATTGATTGGATGAGGAGACCAGGCCTGAGGGCTGCAGGGAGTCTAGGAGGAGTCTCAGGAGCAGGGCCTGAGGAA CTAAGAAGGGGCTCTGGCTGAGACCAGACAGGAGCAGCCACTGTCTGGAATTTTGTCCCCACTGCTGACTTCGAACAACCTCAACTTCAA ACAGAAAGCCCAGACTCGATGAATTTATCTTTTCTTCAAAGTAGAGAAAGGGTAGCTCTTTTCTTCCCAGGAAATTGTTTATCCATTTAA TAATTTTTAAAAATCACTGGAGTTGGGTGTGGTGGCTCATACCTGGTAATCTCAGCACTTTGAGAGGCCGAAGTGGGCAGATCACTTGAG CTCAGGAGTTCGAGACCAGCCTGGGCAACATAGTGAAACCCTGTCTATACAGAAAATACAAAAATTAGCTGGGTGTGGTGGCATGCAACT GTTGTCCTAGCTACTCTGGAGCCTGAGGTGGGAGGATCACTTGAGCCTGGAAGGCGGAGGTTGCAGTGAGCCATGATCGCACCACTGCAC TCCAGCCTGGATGACAGAGTGATACCCTGTCTAAAAAAAAAAAAATAACTGGGATAAAACAACTCGAAAGACCCTTATAAAGATTTTACC CGTAACTCTGTAGAGCAAATAACTTCCTGCTTTAGGCAAAGCTCTTTGTGTGTAAGTTCGATTGGAAGAGGAGGGCTGGTGGGGGGAGAT TCTCTACTTTGGTCATGAGATTAACATTAAAAGTTTGAGGAAGGTTGCTCTATATATTGGCTGCCTGTTTCTAAGACTGAAAATAAAAGC ACAGTAAAATATCAACAAGTATACAGAAAATATACATTTGTAGAAAATTAGCTTTTTTTTTTTTTTTTGCTAAGTACTTCATATAAACTA GTATTTGCTTTCTAGATTAAAGAATATCTCCTCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCCGAGGTGGATGGA CCACGATGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTCCTAAAGATACAAAAAAAATTAGCCAGGCGTGGCA GTGGGCGCCTGTAATCCCAGCTACTCAGGAGACTGAGGCAGAGAATTGCTTGAAGCCAGAGGCAGAGGTTGCAATGAGCCGGGATCACGC CACTGAACTCCAGCCTGGGTGACAGAGTGAGACTCTTGTCTCAAAAAAAAAAAAAAAAAAAAAAATATCTCAGATATTGAAGCGAACCTA TAAATAACAGCAGAAGCTGAAGAAAAGATAACGGATCAAAAAGCAGAAGGAGAAAGCTTCCCTGTCCCCAAGGACCTGCCCACAGTCGTG GATGAGAAGTCCCTTGATAAGTAGGGTCTGAACCCACGTGATCAAATGTTAGCTCTGTGAACCTGTGCCAGTGGCTGTGTGTCAGTAGCC CAGGGTGATTCAGAAGCTCCATGAAGCAGCCATCTTTCCTGGATCTCTGGAATGTACACATTTGCTGAGATCACAAAGATGAAGCTGGCA GAACCCGAGTGGATATTCATTATTACGAACAGAAGAACAGCCAACAGGAGCCGTGCCATGTGCAACCCCGAGTTGACAGATGCCTCCCCG CTTCTTCTGTGTTTGCCAGTTGTTACAAAATGATCTAGAGAAAAACTGGAACTTGATGGAGAAAGCAATGGCTTACGATTCAGCAGGCTT TCTTGGAGAGTTTACCTAAAGTCTATGTGGACGGTGGCTCAGCTCACCTCTGAGAACAATACGATCTTCACTTTTCAATCTTTCTGCAGC TCTAATTAGTGCCACAGGGAACCATGGATGAAAATGGCTTCTCGTGTTGATATCCATTTGGGGAATAGGATGGATGCAGCTGCTTTTGCT CAAGGGCAGAGTTTTGACTTCAAAGACCCTGAAGAGAACCCAGAAGGAAAACTCTCAGAGGTCAATGGACTATATTCTTTACCTGGGGGA TCGTTGACACCACAGCAGTAAAAGCGAAGTCAGTGTCGTGCTGTCTTGAAATTAGATGACAAGAATGACTGACACCAATAGAGCTGGAAC TGCACTTGGAGCCTGAGTAGCCGGTCTCAGGCTAACCACACCTGTGCTGACCACAGCGTGGCCCGTGTTGTTCATGAGGCATTCTGGCTG TACCTCCACAGGGATGCAAGACTTCCAGTGAGAGGCTGCTTCTGCAAGAAAATACCTGCCTAGAAATGGTCCGCTTTCTCTTCCTAATAA >In-frame_FARS2_ENST00000274680_chr6_5613553_+_LYRM4_ENST00000330636_chr6_5216971_-_8393nt GTCAAAATGGCAGCGCCCAGCGTGCGCGGGTATCTCTGAAGTTGGGGTTTAAGATTCTTGCCCGTGAGAGCGAACGAGCCTGCCGTACTT CTGATTTTGAAACACCTGGGTCTGGGCTTCCCGGGCGAGCGGTGGAACCTGTGAGAAGTTTCTACAATGGTGGGCTCAGCTCTCAGGAGA GGTGCCCATGCATATGTCTACCTGGTGAGTAAGGCCAGTCACATCTCCAGAGGCCATCAGCACCAGGCCTGGGGATCGAGGCCTCCTGCA GCAGAGTGTGCCACCCAAAGAGCTCCAGGCAGTGTGGTGGAGCTGCTGGGCAAATCCTACCCTCAGGACGACCACAGCAACCTCACCCGG AAGGTCCTCACCAGAGTTGGCAGGAACCTGCACAACCAGCAGCATCACCCTCTGTGGCTGATCAAGGAGAGGGTGAAGGAGCACTTCTAC AAGCAGTATGTGGGCCGCTTTGGGACCCCGTTGTTCTCGGTCTACGACAACCTTTCTCCAGTGGTCACGACCTGGCAGAACTTTGACAGC CTGCTCATCCCAGCTGATCACCCCAGCAGGAAGAAGGGGGACAACTATTACCTGAATCGGACTCACATGCTGAGAGCGCACACGTCTGCA CACCAGTGGGACTTGCTGCACGCGGGACTGGATGCCTTCCTGGTGGTGGGTGATGTCTACAGGCGTGACCAGATCGACTCCCAGCACTAC CCTATTTTCCACCAGCTGGAGGCCGTGCGGCTCTTCTCCAAGCATGAGTTATTTGCTGGTATAAAGGATGGAGAAAGCCTGCAGCTCTTT GAACAAAGTTCTCGCTCTGCGCATAAACAAGAGACACACACCATGGAGGCCGTGAAGCTTGTAGAGTTTGATCTTAAGCAAACGCTTACC AGGCTCATGGCACATCTTTTTGGAGATGAGCTGGAGATAAGATGGGTAGACTGCTACTTCCCTTTTACACATCCTTCCTTTGAGATGGAG ATCAACTTTCATGGAGAATGGCTGGAAGTTCTTGGCTGCGGGGTGATGGAACAACAACTGGTCAATTCAGCTGGTGCTCAAGACCGAATC GGCTGGGCTTTTGGCCTAGGATTAGAAAGGCTAGCCATGATCCTCTACGACATCCCTGATATCCGTCTCTTCTGGTGTGAGGACGAGCGC TTCCTGAAGCAGTTCTGTGTATCCAACATTAATCAGAAGGTGAAGTTTCAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCA TTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTC ATAGACAAGTTTGTACATCCAAAAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAA ATTCAAACCCTAGTGAATAAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGGTCCACATTGGCCAACTGTATTCAACTGACAAGCTG ATCATTGAGAATCGAGACATGCCCAGGACCTAGCAAGCCGGGGACCAGCCACCAGTGGCGGCCAGGGACCACCTTCAGCATCCACTCTCT GTTTGAGATGGGGGCTCCCAAAACCAGCTTACAATAGCCTTTTGCGCTGCCTGTCCTGTGGGAGCTGATAAACCAAGTCACATTTGCATT CTGTTGCAGGCTTAGTGAAAAAGGACTGCTGTCTTTCCTTGGTTCAAGTGTTAGAATGGAGAGCTGGAGTTCGTTCAGAATAGTGCTGTG TGTTACCACGTCTCCCCTGCACCCCATTCCTACCTTGTAGCTCATGACCATTGTGTATAGCATTTCTACACTTTGTTTCTTGGTCCTTGG CAATAAAAAGAATGATCTCCCTGAGCCTTTGACCCCAGATAAACCCCTCCCAATTAATGCATTTTCATTTCCTACTGATACAAGGCCTGG AGAGGGCTGTTGGGGGCCCTCAGGGAGGGTTCAACTCTGAGACGAGAACTGCCTTGGTGAAGGCAAGTTCAAGCACCACTTGAGACTGGG GGCAGCATGGAGTAGGGCAGGGCTACGGGGATACACGGTGCACCCTGCAACTTATACCTGAGCCCAGTACAACAAAGGTGACGGGTGTGT AGGTACACACCCAGAGATGGAGCACTGCAGATCAGCAACCTCAGCCCCACCTGGGAATTTGCTGGAAATGCAGGCTCAAGCCCCTCCCCA CACCTGGTGAATGAGAGAGCCCCAGCCTGACCCAAGCCCAGGGCGACTCCCATACCCTGAAGCCTGGGGCATGCTGGGCAGCACCGGTGC CCAAATCTGGCTGGTGGACAGAAGCACCTGGAGAGTTGGAGAGCTTTTTAAAAAGACATCTCTCAGCACTTCCCTCTCTGCAGATTCTGA CTCAGTAAGTGAGGGGTGAGGCACAGTCATTTTTCTCTATTCTGAAGCTCTCCCACTGTTTTCAATGTTTAACCAACTGGGGACCCCTGC TCTTTAAGTATATTACAGGTAATAAAGATATTGTTTGTATGCTTTTATTCTTGGAAACAGATTCATTCCAAACATAGAAAGAACATATTA AATAACTTGCTTGTCATCTGGGGAGTTTACGAGGGACCAGACCTGGCAGAGCGGTTTCTTGTTTCCCTTTGCATACAGTGCTCAGTGGAT TTGGTATCTGTGGGTTAAGGTTTGGAACAGGCTCCTATAAATAGCACCGGTCCTGGAATAGCTGCAGCACTGTCACCCCCTCATTTTAAC TCCGACGGTCATGGGAGTGAGTACGCACTGTCTGAGCCCGTGTTCTTCTCACCCTCATATGAGAACTCATGTCTTCCAGTCGCTTTTAGA GAGCATAGATTTGCTGCAATGATGCGTTCAAATAGATGTAACGTGTAGCCATTCTATTTGGCAGTACAACTTTTGATTTCAGGATAAAGT CTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGCGGTGCGATCTTGGCTCACTGCAACCTCCACCTCCTGGGTT CAAGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGGGCCTGCCACCACGCCCAGCTAATTTTTTGTATTTTTAATAGAG ACGGGGTTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTCGGCCCCCCAAAGTGCTGGTATTACAGGCATGAACCACCACCCCCTGCC AATTTCAGGATAAAGTCCTGAGCATCTGTGAAAATAATGAAGCTCTTAGCAAGTCCCAGATCTCTTACCCTCTAACCAGTTCCTGCCTGG GAGCTGCAGTGTTAGAGCATATGCAAAGCCCTAATTGGGGGAGAGCTGTTCGGTGGACAGTGAACGGAGGTGATGTGGCAAGTATAATCA CTCCCTTCAGCTGACTGTCACGGGGCAGAGCCGCCCAGCCCAGCCCTGTGTGTGGCTCTGGCTCAGGTTTTCCACCTTGCATCAGTGCAG TGGAGTTCGTGGTCACTCAGCAGTGAATGCATCCAACCACGCTACTAACGCACGGCACTGCTGATTTATACTTAATTTAAGCAACTGCTA CTTGGAACCGAAGTCCAGATTTGAACCTCCGTGCTGAAGGCATCAAATTGCCGGCAAGATAACAGCTCCAGAGGAGACTTCTCCCACTCC CCCAGGTTTTACGCAATGAGGCAGTCCACCCAAACTTAACGTGGGCTGCAGGCTGTAACAGCAGGTTGCTTTTGTGTTCATTAAACTGCA TGAATGGGTTTGAACATGCCCAAAGCCTTGCTAATGCAGACTTAATTTTGTAAAATTAACTATGCCTTTGGAATCTGCAGAAAGATACAA ATCCGAATTCTGTGGCAGGAAACGCCACAAACAGGCCTTGGTCCTCCACCTTTCAGGTGTATATCTGGCAGGCAGAGCCTGGCACTGGGT ACTCCCCAACTGAGATGACCCAATATTGATGCTAGAGCTTCGAATAAAGTGGCATTCCCATGGGGGTGACCCCTGGTGTTTCTCTAGGGA AGTATTCCACCTCCTTGACTATGCACCAACTGAGGGGAATGTGGGCAACTCCAACATCCATCATGGCCAGCCTCACAGAACTCTCTAGAA CTTGTGCCTGCTTTGAAGATAGGATCCGGGCTGGGGTCTGGAGATCACTTTGCAGCACTAATATTGAGCAAATGAGAACTACTATCATTA GTTAACTTCCCAGGCAGAACTCATTGGCCGAGCAAGGCTATATCCTAGACTTTCAGAGACAGCTCTGGGCTGGGCTGGCTGTCATGACAT AATAGCTGGGAGATCTTGCACGGCCAAGTACAGGGCTGTGTTGTTCTGATGGCTGTTGGAATCTGGATTTTGGAACTGAAAGAATTGGCT AGATTGCTTTAGGTATACTCCGTCCTGCTGCTAACTAAGTAGCAGTGACCTTTAACTCCCTTCATCCACAGCCTCTCCCGTTAATCTCAA GCCCCACCATACAACCCACCATCATCCAGGAGCAAAAGGGACAGGCAGAGGGTGAAGCCTACAAAGATGACAAACATCAGAGCTCACCTA GTCCAACCCTCAAATCTTCAGGTGTTAAAACAAAGAGCCTGAACATCTGCAGATCACGTACAGAGTCAGGGCCTTTCCCCTAAACCCCTT TCACTCATTCATTTATTCACTCAGTATTGACTAAGGCCACCTAGTGCCAGGTGCCAGGTGCCAGGGAGCAACCAGTGAACAAGACAGACG TACCTTCATAAAGCCTGTGTCTAGCAGGGAAATCTGAGAAGAAAATGACAAGTCTTATGAATGTTACAAAGAGGGAAATATGAGTGCTGC CAGAGCCGATGGGACGGGCCAGGGAAGGGCTCCCCAGGGGATATTTACACGTGCAAATTAATGATGAGGATTGGCTGTGTGAAGGTGGGG AGAGGAGCTCTCTAGGCAGGAGGAACAGCACATGCAAAGCCCTTAATTGGGGGAGAGGGTAGTTCCATGCAAAGAACTAAAGGGAGTCTG GGATGGTGGCAGCCAAGGAAGAGGGCTCTTTCCACATCGTGGACGGCCTTGGAGCCTCAGCCTAAGGATGGTGAGCAACTCGGGAGTTTT TAGGCAAGATGAGGTTTTTGTTTTGTTTTGTTTTGTTTTTTTGAGACAGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATAAT CTCAGCTCACTACAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCACGCCACCA TGCCCAGCTAAGTTTTATATTTTTTAGTAGACACAGGATTTCGCCATGTTGGCCAGGCTGCTCTTGAACTCCTGACCCCAGATGATCCGC CTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCCCCCGACCGAAGTTTGTATTTTTTAAAAGGTCACATTGTCTGC TTTTGAGGGGATACACTGGGAGAGATGCAGGGAGACCAGCTTTTCGGAGGAGTGGGGGATTGGGTGTGGCATTCCAGGCAAGCGATGGTG ACTTCACCAAGAGGCAACAGCTGAACAGAAGCAGAGTCAGCATCACCCTGAGAACTGGCTGGGGTGGGCCGCCATTGAAGGAGGACAGGA AACCTGGAGCAGAGCTGCCCCAGCTGAGCACAGCCCGAGCTCCCCAGCCCACCTGCCGATGCGCGAGAAAGTCCACAGAGTCCCCTAGCC TGGTCTAGCTTAGGTCAGTCATATTCAGCCACCCCTCAGACATGTGCTAAATAATTAACTGTTACATTAGTCACTGAGTTTGGAGGTAGA TTATTATGAAGTAACAGCAAACTAATACAGAGAGCATCTCTGTATTAATGTATTAATGTATTACTTTCTCAGGGCCACATAGCAAACCAA AGAGTAGGCAGACAAACGGCCAAAACTGCAGGTCTCCTGTATGGGGACATTTCCACAAATATCTTCAGAATACTGGTCACTCCCTTTAGA GAACAAGTCCTGGAGAAACAGTCGAAACAGTCATCACGTGTCCTACAGATGGAAGGGCTGGCCAACCAGAAAGAAAAGAAAAAGTCGAGT CAGCAGAACTTGGTGATTGATTGGATGAGGAGACCAGGCCTGAGGGCTGCAGGGAGTCTAGGAGGAGTCTCAGGAGCAGGGCCTGAGGAA CTAAGAAGGGGCTCTGGCTGAGACCAGACAGGAGCAGCCACTGTCTGGAATTTTGTCCCCACTGCTGACTTCGAACAACCTCAACTTCAA ACAGAAAGCCCAGACTCGATGAATTTATCTTTTCTTCAAAGTAGAGAAAGGGTAGCTCTTTTCTTCCCAGGAAATTGTTTATCCATTTAA TAATTTTTAAAAATCACTGGAGTTGGGTGTGGTGGCTCATACCTGGTAATCTCAGCACTTTGAGAGGCCGAAGTGGGCAGATCACTTGAG CTCAGGAGTTCGAGACCAGCCTGGGCAACATAGTGAAACCCTGTCTATACAGAAAATACAAAAATTAGCTGGGTGTGGTGGCATGCAACT GTTGTCCTAGCTACTCTGGAGCCTGAGGTGGGAGGATCACTTGAGCCTGGAAGGCGGAGGTTGCAGTGAGCCATGATCGCACCACTGCAC TCCAGCCTGGATGACAGAGTGATACCCTGTCTAAAAAAAAAAAAATAACTGGGATAAAACAACTCGAAAGACCCTTATAAAGATTTTACC CGTAACTCTGTAGAGCAAATAACTTCCTGCTTTAGGCAAAGCTCTTTGTGTGTAAGTTCGATTGGAAGAGGAGGGCTGGTGGGGGGAGAT TCTCTACTTTGGTCATGAGATTAACATTAAAAGTTTGAGGAAGGTTGCTCTATATATTGGCTGCCTGTTTCTAAGACTGAAAATAAAAGC ACAGTAAAATATCAACAAGTATACAGAAAATATACATTTGTAGAAAATTAGCTTTTTTTTTTTTTTTTGCTAAGTACTTCATATAAACTA GTATTTGCTTTCTAGATTAAAGAATATCTCCTCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCCGAGGTGGATGGA CCACGATGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTCCTAAAGATACAAAAAAAATTAGCCAGGCGTGGCA GTGGGCGCCTGTAATCCCAGCTACTCAGGAGACTGAGGCAGAGAATTGCTTGAAGCCAGAGGCAGAGGTTGCAATGAGCCGGGATCACGC CACTGAACTCCAGCCTGGGTGACAGAGTGAGACTCTTGTCTCAAAAAAAAAAAAAAAAAAAAAAATATCTCAGATATTGAAGCGAACCTA TAAATAACAGCAGAAGCTGAAGAAAAGATAACGGATCAAAAAGCAGAAGGAGAAAGCTTCCCTGTCCCCAAGGACCTGCCCACAGTCGTG GATGAGAAGTCCCTTGATAAGTAGGGTCTGAACCCACGTGATCAAATGTTAGCTCTGTGAACCTGTGCCAGTGGCTGTGTGTCAGTAGCC CAGGGTGATTCAGAAGCTCCATGAAGCAGCCATCTTTCCTGGATCTCTGGAATGTACACATTTGCTGAGATCACAAAGATGAAGCTGGCA GAACCCGAGTGGATATTCATTATTACGAACAGAAGAACAGCCAACAGGAGCCGTGCCATGTGCAACCCCGAGTTGACAGATGCCTCCCCG CTTCTTCTGTGTTTGCCAGTTGTTACAAAATGATCTAGAGAAAAACTGGAACTTGATGGAGAAAGCAATGGCTTACGATTCAGCAGGCTT TCTTGGAGAGTTTACCTAAAGTCTATGTGGACGGTGGCTCAGCTCACCTCTGAGAACAATACGATCTTCACTTTTCAATCTTTCTGCAGC TCTAATTAGTGCCACAGGGAACCATGGATGAAAATGGCTTCTCGTGTTGATATCCATTTGGGGAATAGGATGGATGCAGCTGCTTTTGCT CAAGGGCAGAGTTTTGACTTCAAAGACCCTGAAGAGAACCCAGAAGGAAAACTCTCAGAGGTCAATGGACTATATTCTTTACCTGGGGGA TCGTTGACACCACAGCAGTAAAAGCGAAGTCAGTGTCGTGCTGTCTTGAAATTAGATGACAAGAATGACTGACACCAATAGAGCTGGAAC TGCACTTGGAGCCTGAGTAGCCGGTCTCAGGCTAACCACACCTGTGCTGACCACAGCGTGGCCCGTGTTGTTCATGAGGCATTCTGGCTG TACCTCCACAGGGATGCAAGACTTCCAGTGAGAGGCTGCTTCTGCAAGAAAATACCTGCCTAGAAATGGTCCGCTTTCTCTTCCTAATAA |
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FusionGenePPI for FARS2_LYRM4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FARS2 | USP45, G3BP2, ICT1, ISG15, CUL3, RCBTB2, KRT13, KRT31, TRIM27, TADA2A, TFCP2, MKRN3, STX11, CALCOCO2, MID2, IKZF3, APPL1, ADAMTSL4, AGTRAP, TRIM54, HMBOX1, CMTM5, KRT40, KRTAP10-7, KRTAP10-9, KRTAP10-5, KRTAP10-3, NOTCH2NL, ENO1, SHMT2, NXF1, HIST1H1A, ZC3H3, HNRNPA1, GAMT, STAT5A, TOMM40, CHST15, NEDD1, CHCHD2, MRPL38, HIST1H1E, HIST1H1T, ZCRB1 | LYRM4 | PVRL2, ZWINT, HLA-DPB1, NDUFAB1, CDNF, NFS1, ISCU, LYRM4, FXN, IDE, NRD1, CHCHD2, PMPCA, PMPCB, HOGA1, DDAH1, ECH1, BCKDHA, C1QBP, KLHL22, GPX7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FARS2_LYRM4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FARS2_LYRM4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FARS2 | C3554168 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 14 | 2 | ORPHANET;UNIPROT |
| Tgene | LYRM4 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | LYRM4 | C3810055 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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