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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12954

FusionGeneSummary for FARS2_CDYL

check button Fusion gene summary
Fusion gene informationFusion gene name: FARS2_CDYL
Fusion gene ID: 12954
HgeneTgene
Gene symbol

FARS2

CDYL

Gene ID

10667

9425

Gene namephenylalanyl-tRNA synthetase 2, mitochondrialchromodomain Y like
SynonymsCOXPD14|FARS1|HSPC320|PheRS|SPG77CDYL1
Cytomap

6p25.1

6p25.1

Type of geneprotein-codingprotein-coding
Descriptionphenylalanine--tRNA ligase, mitochondrialdJ236A3.1 (phenylalanine-tRNA synthetase)dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase))mitochondrial PHERSphenylalanine tRNA ligase 2, mitochondrialphenylalanine translasephenylalanine-tRNA synthetase 1 (chromodomain Y-like proteinCDY-like, autosomalchromodomain protein, Y-likecrotonyl-CoA hydratasetestis-specific chromodomain Y-like protein
Modification date2018052320180523
UniProtAcc

O95363

Q9Y232

Ensembl transtripts involved in fusion geneENST00000324331, ENST00000274680, 
ENST00000328908, ENST00000397588, 
ENST00000472453, ENST00000449732, 
ENST00000343762, 
Fusion gene scores* DoF score13 X 7 X 10=9106 X 8 X 5=240
# samples 1412
** MAII scorelog2(14/910*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/240*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FARS2 [Title/Abstract] AND CDYL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFARS2

GO:0006432

phenylalanyl-tRNA aminoacylation

10329163

HgeneFARS2

GO:0008033

tRNA processing

10329163

TgeneCDYL

GO:0120094

negative regulation of peptidyl-lysine crotonylation

28803779


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-WE-A8K1-06AFARS2chr6

5261893

+CDYLchr6

4891947

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000324331ENST00000328908FARS2chr6

5261893

+CDYLchr6

4891947

+
intron-3CDSENST00000324331ENST00000397588FARS2chr6

5261893

+CDYLchr6

4891947

+
intron-intronENST00000324331ENST00000472453FARS2chr6

5261893

+CDYLchr6

4891947

+
intron-5UTRENST00000324331ENST00000449732FARS2chr6

5261893

+CDYLchr6

4891947

+
intron-5UTRENST00000324331ENST00000343762FARS2chr6

5261893

+CDYLchr6

4891947

+
5UTR-3CDSENST00000274680ENST00000328908FARS2chr6

5261893

+CDYLchr6

4891947

+
5UTR-3CDSENST00000274680ENST00000397588FARS2chr6

5261893

+CDYLchr6

4891947

+
5UTR-intronENST00000274680ENST00000472453FARS2chr6

5261893

+CDYLchr6

4891947

+
5UTR-5UTRENST00000274680ENST00000449732FARS2chr6

5261893

+CDYLchr6

4891947

+
5UTR-5UTRENST00000274680ENST00000343762FARS2chr6

5261893

+CDYLchr6

4891947

+

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FusionProtFeatures for FARS2_CDYL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FARS2

O95363

CDYL

Q9Y232

Is responsible for the charging of tRNA(Phe) withphenylalanine in mitochondrial translation. To a lesser extent,also catalyzes direct attachment of m-Tyr (an oxidized version ofPhe) to tRNA(Phe), thereby opening the way for delivery of themisacylated tRNA to the ribosome and incorporation of ROS-damagedamino acid into proteins. {ECO:0000269|PubMed:19549855,ECO:0000269|PubMed:22833457}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FARS2_CDYL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FARS2_CDYL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FARS2USP45, G3BP2, ICT1, ISG15, CUL3, RCBTB2, KRT13, KRT31, TRIM27, TADA2A, TFCP2, MKRN3, STX11, CALCOCO2, MID2, IKZF3, APPL1, ADAMTSL4, AGTRAP, TRIM54, HMBOX1, CMTM5, KRT40, KRTAP10-7, KRTAP10-9, KRTAP10-5, KRTAP10-3, NOTCH2NL, ENO1, SHMT2, NXF1, HIST1H1A, ZC3H3, HNRNPA1, GAMT, STAT5A, TOMM40, CHST15, NEDD1, CHCHD2, MRPL38, HIST1H1E, HIST1H1T, ZCRB1CDYLHDAC1, HDAC2, SMARCA4, REST, SETDB1, ZNF644, SMARCB1, EHMT2, HIST1H3A, CTBP1, WIZ, EZH2, SUZ12, MYC, MIER1, MIER2, RBBP4, HECW2, HIST3H3, FAS, PLAUR, TNF, HIST1H2BA, HIST1H2BG, C10orf12, NOP9, CYBRD1, FAM136A, SLC15A1, EFNB3, LAMP2, CD79A, KLK6, C1orf85, APOM, BSG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FARS2_CDYL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FARS2_CDYL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFARS2C3554168COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 142ORPHANET;UNIPROT
TgeneCDYLC0149925Small cell carcinoma of lung1CTD_human