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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12946

FusionGeneSummary for FARP1_SYN1

check button Fusion gene summary
Fusion gene informationFusion gene name: FARP1_SYN1
Fusion gene ID: 12946
HgeneTgene
Gene symbol

FARP1

SYN1

Gene ID

10160

6853

Gene nameFERM, ARH/RhoGEF and pleckstrin domain protein 1synapsin I
SynonymsCDEP|FARP1-IT1|PLEKHC2|PPP1R75SYN1a|SYN1b|SYNI
Cytomap

13q32.2

Xp11.3-p11.23

Type of geneprotein-codingprotein-coding
DescriptionFERM, ARHGEF and pleckstrin domain-containing protein 1FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)FERM, RhoGEF and pleckstrin domain-containing protein 1PH domain-containing family C member 2chondrocyte-derived ezrin-lisynapsin-1brain protein 4.1synapsin Ib
Modification date2018051920180527
UniProtAcc

Q9Y4F1

P17600

Ensembl transtripts involved in fusion geneENST00000595437, ENST00000376586, 
ENST00000319562, ENST00000376581, 
ENST00000593990, 
ENST00000340666, 
ENST00000295987, 
Fusion gene scores* DoF score14 X 11 X 7=10783 X 3 X 1=9
# samples 133
** MAII scorelog2(13/1078*10)=-3.05177364972405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FARP1 [Title/Abstract] AND SYN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFARP1

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI910121FARP1chr13

99059284

-SYN1chrX

47446088

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000595437ENST00000340666FARP1chr13

99059284

-SYN1chrX

47446088

-
intron-intronENST00000595437ENST00000295987FARP1chr13

99059284

-SYN1chrX

47446088

-
intron-intronENST00000376586ENST00000340666FARP1chr13

99059284

-SYN1chrX

47446088

-
intron-intronENST00000376586ENST00000295987FARP1chr13

99059284

-SYN1chrX

47446088

-
intron-intronENST00000319562ENST00000340666FARP1chr13

99059284

-SYN1chrX

47446088

-
intron-intronENST00000319562ENST00000295987FARP1chr13

99059284

-SYN1chrX

47446088

-
intron-intronENST00000376581ENST00000340666FARP1chr13

99059284

-SYN1chrX

47446088

-
intron-intronENST00000376581ENST00000295987FARP1chr13

99059284

-SYN1chrX

47446088

-
intron-intronENST00000593990ENST00000340666FARP1chr13

99059284

-SYN1chrX

47446088

-
intron-intronENST00000593990ENST00000295987FARP1chr13

99059284

-SYN1chrX

47446088

-

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FusionProtFeatures for FARP1_SYN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FARP1

Q9Y4F1

SYN1

P17600

Functions as guanine nucleotide exchange factor forRAC1. May play a role in semaphorin signaling. Plays a role in theassembly and disassembly of dendritic filopodia, the formation ofdendritic spines, regulation of dendrite length and ultimately theformation of synapses (By similarity). {ECO:0000250}. Neuronal phosphoprotein that coats synaptic vesicles,binds to the cytoskeleton, and is believed to function in theregulation of neurotransmitter release. The complex formed withNOS1 and CAPON proteins is necessary for specific nitric-oxidfunctions at a presynaptic level.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FARP1_SYN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FARP1_SYN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FARP1_SYN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FARP1_SYN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFARP1C0236969Substance-Related Disorders1CTD_human
TgeneSYN1C0011570Mental Depression4PSYGENET
TgeneSYN1C0011581Depressive disorder4PSYGENET
TgeneSYN1C0036341Schizophrenia2PSYGENET