FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12932

FusionGeneSummary for FAR2_AGMO

check button Fusion gene summary
Fusion gene informationFusion gene name: FAR2_AGMO
Fusion gene ID: 12932
HgeneTgene
Gene symbol

FAR2

AGMO

Gene ID

55711

392636

Gene namefatty acyl-CoA reductase 2alkylglycerol monooxygenase
SynonymsHEL-S-81|MLSTD1|SDR10E2TMEM195
Cytomap

12p11.22

7p21.2

Type of geneprotein-codingprotein-coding
Descriptionfatty acyl-CoA reductase 2epididymis secretory protein Li 81male sterility domain-containing protein 1short chain dehydrogenase/reductase family 10E, member 2alkylglycerol monooxygenaseglyceryl-ether monooxygenasetransmembrane protein 195
Modification date2018052320180523
UniProtAcc

Q96K12

Q6ZNB7

Ensembl transtripts involved in fusion geneENST00000536681, ENST00000549080, 
ENST00000182377, ENST00000547116, 
ENST00000342526, ENST00000498264, 
Fusion gene scores* DoF score2 X 1 X 2=42 X 1 X 2=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: FAR2 [Title/Abstract] AND AGMO [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAR2

GO:0035336

long-chain fatty-acyl-CoA metabolic process

15220348

TgeneAGMO

GO:0006643

membrane lipid metabolic process

20643956

TgeneAGMO

GO:0046485

ether lipid metabolic process

20643956


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-KQ-A41Q-01AFAR2chr12

29474857

+AGMOchr7

15240984

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000536681ENST00000342526FAR2chr12

29474857

+AGMOchr7

15240984

-
5CDS-intronENST00000536681ENST00000498264FAR2chr12

29474857

+AGMOchr7

15240984

-
intron-3CDSENST00000549080ENST00000342526FAR2chr12

29474857

+AGMOchr7

15240984

-
intron-intronENST00000549080ENST00000498264FAR2chr12

29474857

+AGMOchr7

15240984

-
Frame-shiftENST00000182377ENST00000342526FAR2chr12

29474857

+AGMOchr7

15240984

-
5CDS-intronENST00000182377ENST00000498264FAR2chr12

29474857

+AGMOchr7

15240984

-
Frame-shiftENST00000547116ENST00000342526FAR2chr12

29474857

+AGMOchr7

15240984

-
5CDS-intronENST00000547116ENST00000498264FAR2chr12

29474857

+AGMOchr7

15240984

-

Top

FusionProtFeatures for FAR2_AGMO


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAR2

Q96K12

AGMO

Q6ZNB7

Catalyzes the reduction of saturated but not unsaturatedC16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity canbe observed with shorter fatty acyl-CoA substrates(PubMed:15220348). It may play a role in the production of etherlipids/plasmalogens and wax monoesters which synthesis requiresfatty alcohols as substrates (By similarity).{ECO:0000250|UniProtKB:Q8WVX9, ECO:0000269|PubMed:15220348}. Glyceryl-ether monooxygenase that cleaves the O-alkylbond of ether lipids. Ether lipids are essential components ofbrain membranes. {ECO:0000269|PubMed:20643956}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAR2_AGMO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAR2_AGMO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAR2PEX19, SLC39A4, VSIG4, ERGIC3, IQCF1, ATP2B2, B4GAT1, SCN3B, PCDHGB1, SLC39A12, CHRNA3, VNN2, GRPRAGMO


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAR2_AGMO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAR2_AGMO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource