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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12929

FusionGeneSummary for FAR1_C3orf55

check button Fusion gene summary
Fusion gene informationFusion gene name: FAR1_C3orf55
Fusion gene ID: 12929
HgeneTgene
Gene symbol

FAR1

C3orf55

Gene ID

84188

152078

Gene namefatty acyl-CoA reductase 1PQ loop repeat containing 2 like
SynonymsMLSTD2|PFCRD|SDR10E1C3orf55
Cytomap

11p15.3

3q25.32

Type of geneprotein-codingprotein-coding
Descriptionfatty acyl-CoA reductase 1male sterility domain-containing protein 2short chain dehydrogenase/reductase family 10E, member 1putative uncharacterized protein PQLC2LPQ-loop repeat-containing protein 2-like
Modification date2018052320180329
UniProtAcc

Q8WVX9

Ensembl transtripts involved in fusion geneENST00000354817, ENST00000527202, 
ENST00000532502, 
ENST00000312275, 
ENST00000498159, ENST00000468043, 
ENST00000459838, ENST00000461040, 
ENST00000449199, ENST00000426338, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 1 X 2=4
# samples 62
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: FAR1 [Title/Abstract] AND C3orf55 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAR1

GO:0008611

ether lipid biosynthetic process

24108123

HgeneFAR1

GO:0035336

long-chain fatty-acyl-CoA metabolic process

15220348

HgeneFAR1

GO:0046474

glycerophospholipid biosynthetic process

20071337


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3LT-01AFAR1chr11

13722039

+C3orf55chr3

157271019

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000354817ENST00000312275FAR1chr11

13722039

+C3orf55chr3

157271019

+
5CDS-intronENST00000354817ENST00000498159FAR1chr11

13722039

+C3orf55chr3

157271019

+
5CDS-5UTRENST00000354817ENST00000468043FAR1chr11

13722039

+C3orf55chr3

157271019

+
5CDS-5UTRENST00000354817ENST00000459838FAR1chr11

13722039

+C3orf55chr3

157271019

+
5CDS-5UTRENST00000354817ENST00000461040FAR1chr11

13722039

+C3orf55chr3

157271019

+
5CDS-5UTRENST00000354817ENST00000449199FAR1chr11

13722039

+C3orf55chr3

157271019

+
5CDS-5UTRENST00000354817ENST00000426338FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000527202ENST00000312275FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-intronENST00000527202ENST00000498159FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000527202ENST00000468043FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000527202ENST00000459838FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000527202ENST00000461040FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000527202ENST00000449199FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000527202ENST00000426338FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000532502ENST00000312275FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-intronENST00000532502ENST00000498159FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000532502ENST00000468043FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000532502ENST00000459838FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000532502ENST00000461040FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000532502ENST00000449199FAR1chr11

13722039

+C3orf55chr3

157271019

+
intron-5UTRENST00000532502ENST00000426338FAR1chr11

13722039

+C3orf55chr3

157271019

+

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FusionProtFeatures for FAR1_C3orf55


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAR1

Q8WVX9

C3orf55

Catalyzes the reduction of saturated and unsaturated C16or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348,PubMed:24108123). It plays an essential role in the production ofether lipids/plasmalogens which synthesis requires fatty alcohols(PubMed:20071337, PubMed:24108123). In parallel, it is alsorequired for wax monoesters production since fatty alcohols alsoconstitute a substrate for their synthesis (By similarity).{ECO:0000250|UniProtKB:Q922J9, ECO:0000269|PubMed:15220348,ECO:0000269|PubMed:20071337, ECO:0000269|PubMed:24108123}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAR1_C3orf55


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAR1_C3orf55


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAR1C20orf24, SLC2A4, CUL3, CUL5, ATXN1, IQCB1, PEX14, CLN3, CCDC8, EGFR, CYLDC3orf55


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAR1_C3orf55


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAR1_C3orf55


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAR1C4015344PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER1ORPHANET;UNIPROT