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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12923

FusionGeneSummary for FANCG_FANCG

check button Fusion gene summary
Fusion gene informationFusion gene name: FANCG_FANCG
Fusion gene ID: 12923
HgeneTgene
Gene symbol

FANCG

FANCG

Gene ID

2189

2189

Gene nameFA complementation group GFA complementation group G
SynonymsFAG|XRCC9FAG|XRCC9
Cytomap

9p13.3

9p13.3

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia group G proteinDNA repair protein XRCC9Fanconi anemia complementation group GX-ray repair complementing defective repair in Chinese hamster cells 9X-ray repair, complementing defective, in Chinese hamster, 9truncated Fanconi anemia groFanconi anemia group G proteinDNA repair protein XRCC9Fanconi anemia complementation group GX-ray repair complementing defective repair in Chinese hamster cells 9X-ray repair, complementing defective, in Chinese hamster, 9truncated Fanconi anemia gro
Modification date2018052220180522
UniProtAcc

O15287

O15287

Ensembl transtripts involved in fusion geneENST00000378643, ENST00000476212, 
ENST00000378643, ENST00000476212, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: FANCG [Title/Abstract] AND FANCG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ224571FANCGchr9

35076495

-FANCGchr9

35079525

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000378643ENST00000378643FANCGchr9

35076495

-FANCGchr9

35079525

-
intron-intronENST00000378643ENST00000476212FANCGchr9

35076495

-FANCGchr9

35079525

-
intron-5UTRENST00000476212ENST00000378643FANCGchr9

35076495

-FANCGchr9

35079525

-
intron-intronENST00000476212ENST00000476212FANCGchr9

35076495

-FANCGchr9

35079525

-

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FusionProtFeatures for FANCG_FANCG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FANCG

O15287

FANCG

O15287

DNA repair protein that may operate in a postreplicationrepair or a cell cycle checkpoint function. May be implicated ininterstrand DNA cross-link repair and in the maintenance of normalchromosome stability. Candidate tumor suppressor gene. DNA repair protein that may operate in a postreplicationrepair or a cell cycle checkpoint function. May be implicated ininterstrand DNA cross-link repair and in the maintenance of normalchromosome stability. Candidate tumor suppressor gene.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FANCG_FANCG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FANCG_FANCG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FANCG_FANCG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FANCG_FANCG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFANCGC0015625Fanconi Anemia2CTD_human;ORPHANET
HgeneFANCGC0026636Mouth Diseases1CTD_human
HgeneFANCGC3469527fanconi anemia complementation group g1UNIPROT
TgeneFANCGC0015625Fanconi Anemia2CTD_human;ORPHANET
TgeneFANCGC0026636Mouth Diseases1CTD_human
TgeneFANCGC3469527fanconi anemia complementation group g1UNIPROT