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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12909

FusionGeneSummary for FANCA_FANCA

check button Fusion gene summary
Fusion gene informationFusion gene name: FANCA_FANCA
Fusion gene ID: 12909
HgeneTgene
Gene symbol

FANCA

FANCA

Gene ID

2175

2175

Gene nameFA complementation group AFA complementation group A
SynonymsFA|FA-H|FA1|FAA|FACA|FAH|FANCHFA|FA-H|FA1|FAA|FACA|FAH|FANCH
Cytomap

16q24.3

16q24.3

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia group A proteinFanconi anemia complementation group AFanconi anemia, complementation group HFanconi anemia, type 1Fanconi anemia group A proteinFanconi anemia complementation group AFanconi anemia, complementation group HFanconi anemia, type 1
Modification date2018052220180522
UniProtAcc

O15360

O15360

Ensembl transtripts involved in fusion geneENST00000389301, ENST00000568369, 
ENST00000567284, ENST00000389302, 
ENST00000563673, ENST00000534992, 
ENST00000543736, 		ENST00000389301, 
ENST00000568369, ENST00000567284, 
ENST00000389302, ENST00000563673, 
ENST00000534992, ENST00000543736, 
Fusion gene scores* DoF score4 X 4 X 4=646 X 9 X 5=270
# samples 410
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FANCA [Title/Abstract] AND FANCA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF334909FANCAchr16

89877722

-FANCAchr16

89877617

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000389301ENST00000389301FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389301ENST00000568369FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389301ENST00000567284FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389301ENST00000389302FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389301ENST00000563673FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389301ENST00000534992FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389301ENST00000543736FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000568369ENST00000389301FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000568369ENST00000568369FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000568369ENST00000567284FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000568369ENST00000389302FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000568369ENST00000563673FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000568369ENST00000534992FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000568369ENST00000543736FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000567284ENST00000389301FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000567284ENST00000568369FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000567284ENST00000567284FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000567284ENST00000389302FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000567284ENST00000563673FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000567284ENST00000534992FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000567284ENST00000543736FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389302ENST00000389301FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389302ENST00000568369FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389302ENST00000567284FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389302ENST00000389302FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389302ENST00000563673FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389302ENST00000534992FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000389302ENST00000543736FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000563673ENST00000389301FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000563673ENST00000568369FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000563673ENST00000567284FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000563673ENST00000389302FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000563673ENST00000563673FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000563673ENST00000534992FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000563673ENST00000543736FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000534992ENST00000389301FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000534992ENST00000568369FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000534992ENST00000567284FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000534992ENST00000389302FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000534992ENST00000563673FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000534992ENST00000534992FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000534992ENST00000543736FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000543736ENST00000389301FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000543736ENST00000568369FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000543736ENST00000567284FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000543736ENST00000389302FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000543736ENST00000563673FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000543736ENST00000534992FANCAchr16

89877722

-FANCAchr16

89877617

+
intron-intronENST00000543736ENST00000543736FANCAchr16

89877722

-FANCAchr16

89877617

+

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FusionProtFeatures for FANCA_FANCA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FANCA

O15360

FANCA

O15360


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FANCA_FANCA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FANCA_FANCA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FANCA_FANCA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FANCA_FANCA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFANCAC3469521FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)10UNIPROT
HgeneFANCAC0005695Bladder Neoplasm1CTD_human
HgeneFANCAC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneFANCAC0036095Salivary Gland Neoplasms1CTD_human
TgeneFANCAC3469521FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)10UNIPROT
TgeneFANCAC0005695Bladder Neoplasm1CTD_human
TgeneFANCAC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneFANCAC0036095Salivary Gland Neoplasms1CTD_human