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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12905

FusionGeneSummary for FAM98C_WDR33

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM98C_WDR33
Fusion gene ID: 12905
HgeneTgene
Gene symbol

FAM98C

WDR33

Gene ID

147965

55339

Gene namefamily with sequence similarity 98 member CWD repeat domain 33
Synonyms-NET14|WDC146
Cytomap

19q13.2

2q14.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM98Cpre-mRNA 3' end processing protein WDR33WD repeat-containing protein 33WD repeat-containing protein WDC146
Modification date2018052320180523
UniProtAcc

Q17RN3

Q9C0J8

Ensembl transtripts involved in fusion geneENST00000588262, ENST00000252530, 
ENST00000343358, ENST00000585954, 
ENST00000322313, ENST00000393006, 
ENST00000409658, 
Fusion gene scores* DoF score5 X 3 X 4=603 X 3 X 1=9
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM98C [Title/Abstract] AND WDR33 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI655327FAM98Cchr19

38899778

+WDR33chr2

128520491

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000588262ENST00000322313FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-intronENST00000588262ENST00000393006FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-3UTRENST00000588262ENST00000409658FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-intronENST00000252530ENST00000322313FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-intronENST00000252530ENST00000393006FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-3UTRENST00000252530ENST00000409658FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-intronENST00000343358ENST00000322313FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-intronENST00000343358ENST00000393006FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-3UTRENST00000343358ENST00000409658FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-intronENST00000585954ENST00000322313FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-intronENST00000585954ENST00000393006FAM98Cchr19

38899778

+WDR33chr2

128520491

+
intron-3UTRENST00000585954ENST00000409658FAM98Cchr19

38899778

+WDR33chr2

128520491

+

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FusionProtFeatures for FAM98C_WDR33


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM98C

Q17RN3

WDR33

Q9C0J8

Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM98C_WDR33


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM98C_WDR33


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM98C_WDR33


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM98C_WDR33


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource