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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12897

FusionGeneSummary for FAM98A_ZCCHC17

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM98A_ZCCHC17
Fusion gene ID: 12897
HgeneTgene
Gene symbol

FAM98A

ZCCHC17

Gene ID

25940

51538

Gene namefamily with sequence similarity 98 member Azinc finger CCHC-type containing 17
Synonyms-HSPC251|PS1D|pNO40
Cytomap

2p22.3

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM98Anucleolar protein of 40 kDanucleolar protein 40pnn-interacting nucleolar proteinputative S1 RNA binding domain proteinzinc finger CCHC domain-containing protein 17zinc finger, CCHC domain containing 17
Modification date2018052320180522
UniProtAcc

Q8NCA5

Q9NP64

Ensembl transtripts involved in fusion geneENST00000238823, ENST00000403368, 
ENST00000441530, ENST00000498340, 
ENST00000344147, ENST00000479629, 
ENST00000373714, ENST00000546109, 
ENST00000422613, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 8 X 3=120
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM98A [Title/Abstract] AND ZCCHC17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ776211FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000238823ENST00000344147FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000238823ENST00000479629FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000238823ENST00000373714FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000238823ENST00000546109FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000238823ENST00000422613FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-3CDSENST00000403368ENST00000344147FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000403368ENST00000479629FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000403368ENST00000373714FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000403368ENST00000546109FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000403368ENST00000422613FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-3CDSENST00000441530ENST00000344147FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000441530ENST00000479629FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000441530ENST00000373714FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000441530ENST00000546109FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000441530ENST00000422613FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-3CDSENST00000498340ENST00000344147FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000498340ENST00000479629FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000498340ENST00000373714FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000498340ENST00000546109FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-
intron-intronENST00000498340ENST00000422613FAM98Achr2

33809286

+ZCCHC17chr1

31837025

-

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FusionProtFeatures for FAM98A_ZCCHC17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM98A

Q8NCA5

ZCCHC17

Q9NP64

Positively stimulates PRMT1-induced protein argininemethylation (PubMed:28040436). Involved in skeletal homeostasis(By similarity). Positively regulates lysosome peripheraldistribution and ruffled border formation in osteoclasts (Bysimilarity). Promotes colorectal cancer cell malignancy(PubMed:28040436). {ECO:0000250|UniProtKB:Q3TJZ6,ECO:0000269|PubMed:28040436}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM98A_ZCCHC17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM98A_ZCCHC17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM98A_ZCCHC17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM98A_ZCCHC17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource