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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12890

FusionGeneSummary for FAM96A_MRPL52

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM96A_MRPL52
Fusion gene ID: 12890
HgeneTgene
Gene symbol

FAM96A

MRPL52

Gene ID

122704

Gene namemitochondrial ribosomal protein L52
Synonyms-
Cytomap

14q11.2

Type of geneprotein-coding
Description39S ribosomal protein L52, mitochondrialL52mtMRP-L52mitochondrial large ribosomal subunit protein mL52
Modification date20180523
UniProtAcc

Q9H5X1

Q86TS9

Ensembl transtripts involved in fusion geneENST00000300030, ENST00000558779, 
ENST00000380290, ENST00000557835, 
ENST00000559950, 
ENST00000355151, 
ENST00000397496, ENST00000555345, 
ENST00000432849, ENST00000553711, 
ENST00000397505, ENST00000557221, 
ENST00000311892, ENST00000556840, 
ENST00000461594, ENST00000555536, 
Fusion gene scores* DoF score7 X 6 X 3=1263 X 3 X 2=18
# samples 73
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM96A [Title/Abstract] AND MRPL52 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CK826457FAM96Achr15

64366473

+MRPL52chr14

23299118

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000300030ENST00000355151FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000300030ENST00000397496FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000300030ENST00000555345FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000300030ENST00000432849FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000300030ENST00000553711FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000300030ENST00000397505FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000300030ENST00000557221FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000300030ENST00000311892FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000300030ENST00000556840FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000300030ENST00000461594FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000300030ENST00000555536FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000558779ENST00000355151FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000558779ENST00000397496FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000558779ENST00000555345FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000558779ENST00000432849FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000558779ENST00000553711FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000558779ENST00000397505FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000558779ENST00000557221FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000558779ENST00000311892FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000558779ENST00000556840FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000558779ENST00000461594FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000558779ENST00000555536FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000380290ENST00000355151FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000380290ENST00000397496FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000380290ENST00000555345FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000380290ENST00000432849FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000380290ENST00000553711FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000380290ENST00000397505FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000380290ENST00000557221FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000380290ENST00000311892FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000380290ENST00000556840FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000380290ENST00000461594FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000380290ENST00000555536FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000557835ENST00000355151FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000557835ENST00000397496FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000557835ENST00000555345FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000557835ENST00000432849FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000557835ENST00000553711FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000557835ENST00000397505FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000557835ENST00000557221FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000557835ENST00000311892FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000557835ENST00000556840FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000557835ENST00000461594FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000557835ENST00000555536FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000559950ENST00000355151FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000559950ENST00000397496FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000559950ENST00000555345FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000559950ENST00000432849FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000559950ENST00000553711FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000559950ENST00000397505FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000559950ENST00000557221FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-5UTRENST00000559950ENST00000311892FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000559950ENST00000556840FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000559950ENST00000461594FAM96Achr15

64366473

+MRPL52chr14

23299118

+
intron-intronENST00000559950ENST00000555536FAM96Achr15

64366473

+MRPL52chr14

23299118

+

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FusionProtFeatures for FAM96A_MRPL52


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM96A

Q9H5X1

MRPL52

Q86TS9

May play a role in chromosome segregation throughestablishment of sister chromatid cohesion. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM96A_MRPL52


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM96A_MRPL52


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM96A_MRPL52


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM96A_MRPL52


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource