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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12855

FusionGeneSummary for FAM73A_PIGU

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM73A_PIGU
Fusion gene ID: 12855
HgeneTgene
Gene symbol

FAM73A

PIGU

Gene ID

374986

128869

Gene namemitoguardin 1phosphatidylinositol glycan anchor biosynthesis class U
SynonymsFAM73ACDC91L1|GAB1
Cytomap

1p31.1

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionmitoguardin 1family with sequence similarity 73, member Aprotein FAM73Aphosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li
Modification date2018052520180523
UniProtAcc

Q9H490

Ensembl transtripts involved in fusion geneENST00000370791, ENST00000443751, 
ENST00000374820, ENST00000452740, 
ENST00000480175, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 7 X 7=490
# samples 112
** MAII scorelog2(1/1*10)=3.32192809488736log2(12/490*10)=-2.02974734339405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM73A [Title/Abstract] AND PIGU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM73A

GO:0008053

mitochondrial fusion

26711011

TgenePIGU

GO:0006506

GPI anchor biosynthetic process

15034568

TgenePIGU

GO:0046425

regulation of JAK-STAT cascade

15034568


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7792-01AFAM73Achr1

78249036

+PIGUchr20

33225789

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000370791ENST00000374820FAM73Achr1

78249036

+PIGUchr20

33225789

-
In-frameENST00000370791ENST00000452740FAM73Achr1

78249036

+PIGUchr20

33225789

-
5CDS-intronENST00000370791ENST00000480175FAM73Achr1

78249036

+PIGUchr20

33225789

-
intron-3CDSENST00000443751ENST00000374820FAM73Achr1

78249036

+PIGUchr20

33225789

-
intron-3CDSENST00000443751ENST00000452740FAM73Achr1

78249036

+PIGUchr20

33225789

-
intron-intronENST00000443751ENST00000480175FAM73Achr1

78249036

+PIGUchr20

33225789

-

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FusionProtFeatures for FAM73A_PIGU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM73A

PIGU

Q9H490

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Component of the GPI transamidase complex. May beinvolved in the recognition of either the GPI attachment signal orthe lipid portion of GPI. {ECO:0000269|PubMed:12802054}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-211269_28986416RegionNote=May be involved in recognition of long-chain fatty acids in GPI
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-211166_18686416TransmembraneHelical
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-211188_20886416TransmembraneHelical
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-211237_25786416TransmembraneHelical
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-211259_27986416TransmembraneHelical
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-211286_30686416TransmembraneHelical
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-211313_33386416TransmembraneHelical
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-211355_37586416TransmembraneHelical
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-211386_40686416TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM73Achr1:78249036chr20:33225789ENST00000370791+21670_9065633TransmembraneHelical
TgenePIGUchr1:78249036chr20:33225789ENST00000374820-21166_8686416TransmembraneHelical


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FusionGeneSequence for FAM73A_PIGU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FAM73A_ENST00000370791_chr1_78249036_+_PIGU_ENST00000374820_chr20_33225789_-_395aa
MSDCCSAPGISWEAGVGRPAVPGLELQIRRGAMSEETVSESQFSLKTAALRVFDLPLTWYYSLSQFKKQKLLLELDQYAPDVAELIRTPM
EMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKA
FWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEH
PIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITLTFNVGQILL

>In-frame_FAM73A_ENST00000370791_chr1_78249036_+_PIGU_ENST00000452740_chr20_33225789_-_383aa
MSDCCSAPGISWEAGVGRPAVPGLELQIRRGAMSEETVSESQFSLKTAALRVFDLPLTWYYSLSQFKKQKLLLELDQYAPDVAELIRTPM
EMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKA
FWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEH
PIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITLTFNVGQMGF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FAM73A_ENST00000370791_chr1_78249036_+_PIGU_ENST00000374820_chr20_33225789_-_1185nt
ATGTCAGACTGCTGCTCAGCGCCAGGCATCAGCTGGGAAGCTGGCGTGGGCAGGCCAGCTGTACCTGGCCTGGAGCTCCAGATTAGAAGA
GGAGCCATGTCAGAAGAAACAGTAAGTGAATCACAGTTTTCCTTGAAGACAGCAGCGCTAAGAGTGTTTGATCTTCCTCTGACTTGGTAC
TATTCTCTCTCCCAGTTTAAAAAGCAGAAACTCCTCCTAGAACTGGACCAGTATGCCCCAGATGTGGCCGAACTCATCCGGACCCCTATG
GAAATGCGTTACATCCCTTTGAAAGTGGCCCTGTTCTATCTCTTAAATCCTTACACGATTTTGTCTTGTGTTGCCAAGTCTACCTGTGCC
ATCAACAACACCCTCATTGCTTTCTTCATTTTGACTACGATAAAAGGCAGTGCTTTCCTCAGTGCTATTTTTCTTGCCTTAGCGACATAC
CAGTCTCTGTACCCACTCACCTTGTTTGTCCCAGGACTCCTCTATCTCCTCCAGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCC
TTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCCTAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGG
GATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATG
TTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTCAGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCAC
CCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTC
TTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTC
CTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCTTTTATGCCATCACACTGACCTTCAACGTTGGGCAGATCCTGCTC
ATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATG

>In-frame_FAM73A_ENST00000370791_chr1_78249036_+_PIGU_ENST00000452740_chr20_33225789_-_1149nt
ATGTCAGACTGCTGCTCAGCGCCAGGCATCAGCTGGGAAGCTGGCGTGGGCAGGCCAGCTGTACCTGGCCTGGAGCTCCAGATTAGAAGA
GGAGCCATGTCAGAAGAAACAGTAAGTGAATCACAGTTTTCCTTGAAGACAGCAGCGCTAAGAGTGTTTGATCTTCCTCTGACTTGGTAC
TATTCTCTCTCCCAGTTTAAAAAGCAGAAACTCCTCCTAGAACTGGACCAGTATGCCCCAGATGTGGCCGAACTCATCCGGACCCCTATG
GAAATGCGTTACATCCCTTTGAAAGTGGCCCTGTTCTATCTCTTAAATCCTTACACGATTTTGTCTTGTGTTGCCAAGTCTACCTGTGCC
ATCAACAACACCCTCATTGCTTTCTTCATTTTGACTACGATAAAAGGCAGTGCTTTCCTCAGTGCTATTTTTCTTGCCTTAGCGACATAC
CAGTCTCTGTACCCACTCACCTTGTTTGTCCCAGGACTCCTCTATCTCCTCCAGCGGCAGTACATACCTGTGAAAATGAAGAGCAAAGCC
TTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCCTAGTGGTAATCATTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGG
GATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATCTCACTCCAAACATTGGTCTTTTCTGGTACTTCTTTGCAGAGATG
TTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTCAGATCAACGTCTTCTTCTACACCATCCCCTTAGCCATAAAGCTAAAGGAGCAC
CCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTAAGTCCTACCCGACAGTGGGGGACGTGGCGCTCTACATGGCCTTC
TTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTGTCCTCACCTGCATCATCATCGTCTGTTCCCTGCTCTTCCCTGTC
CTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCTTTTATGCCATCACACTGACCTTCAACGTTGGGCAGATGGGCTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_FAM73A_ENST00000370791_chr1_78249036_+_PIGU_ENST00000374820_chr20_33225789_-_1540nt
ACTCCTGACCCCGGAAGGACTCCGCCTTCTCCATGTCAGACTGCTGCTCAGCGCCAGGCATCAGCTGGGAAGCTGGCGTGGGCAGGCCAG
CTGTACCTGGCCTGGAGCTCCAGATTAGAAGAGGAGCCATGTCAGAAGAAACAGTAAGTGAATCACAGTTTTCCTTGAAGACAGCAGCGC
TAAGAGTGTTTGATCTTCCTCTGACTTGGTACTATTCTCTCTCCCAGTTTAAAAAGCAGAAACTCCTCCTAGAACTGGACCAGTATGCCC
CAGATGTGGCCGAACTCATCCGGACCCCTATGGAAATGCGTTACATCCCTTTGAAAGTGGCCCTGTTCTATCTCTTAAATCCTTACACGA
TTTTGTCTTGTGTTGCCAAGTCTACCTGTGCCATCAACAACACCCTCATTGCTTTCTTCATTTTGACTACGATAAAAGGCAGTGCTTTCC
TCAGTGCTATTTTTCTTGCCTTAGCGACATACCAGTCTCTGTACCCACTCACCTTGTTTGTCCCAGGACTCCTCTATCTCCTCCAGCGGC
AGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCCTAGTGGTAATCA
TTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATCTCACTCCAAACA
TTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTCAGATCAACGTCTTCTTCTACA
CCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTAAGTCCTACCCGA
CAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTGTCCTCACCTGCA
TCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCTTTTATGCCATCA
CACTGACCTTCAACGTTGGGCAGATCCTGCTCATCTCTGATTACTTCTATGCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCT
ACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCCTGGCTGGCACAGGGCTGCATGGACCTCAGGGGGCTGTGGG
GCCAGAAGCTGGGCCAAGCCCTCCAGCCAGAGTTGCCAGCAGGCGAGTGCTTGGGCAGAAGAGGTTCGAGTCCAGGGTCACAAGTCTCTG
GTACCAAAAGGGACCCATGGCTGACTGACAGCAAGGCCTATGGGGAAGAACTGGGAGCTCCCCAACTTGGACCCCCACCTTGTGGCTCTG
CACACCAAGGAGCCCCCTCCCAGACAGGAAGGAGAAGAGGCAGGTGAGCAGGGCTTGTTAGATTGTGGCTACTTAATAAATGTTTTTTGT

>In-frame_FAM73A_ENST00000370791_chr1_78249036_+_PIGU_ENST00000452740_chr20_33225789_-_1378nt
ACTCCTGACCCCGGAAGGACTCCGCCTTCTCCATGTCAGACTGCTGCTCAGCGCCAGGCATCAGCTGGGAAGCTGGCGTGGGCAGGCCAG
CTGTACCTGGCCTGGAGCTCCAGATTAGAAGAGGAGCCATGTCAGAAGAAACAGTAAGTGAATCACAGTTTTCCTTGAAGACAGCAGCGC
TAAGAGTGTTTGATCTTCCTCTGACTTGGTACTATTCTCTCTCCCAGTTTAAAAAGCAGAAACTCCTCCTAGAACTGGACCAGTATGCCC
CAGATGTGGCCGAACTCATCCGGACCCCTATGGAAATGCGTTACATCCCTTTGAAAGTGGCCCTGTTCTATCTCTTAAATCCTTACACGA
TTTTGTCTTGTGTTGCCAAGTCTACCTGTGCCATCAACAACACCCTCATTGCTTTCTTCATTTTGACTACGATAAAAGGCAGTGCTTTCC
TCAGTGCTATTTTTCTTGCCTTAGCGACATACCAGTCTCTGTACCCACTCACCTTGTTTGTCCCAGGACTCCTCTATCTCCTCCAGCGGC
AGTACATACCTGTGAAAATGAAGAGCAAAGCCTTCTGGATCTTTTCTTGGGAGTATGCCATGATGTATGTGGGAAGCCTAGTGGTAATCA
TTTGCCTCTCCTTCTTCCTTCTCAGCTCTTGGGATTTCATCCCCGCAGTCTATGGCTTTATACTTTCTGTTCCAGATCTCACTCCAAACA
TTGGTCTTTTCTGGTACTTCTTTGCAGAGATGTTTGAGCACTTCAGCCTCTTCTTTGTATGTGTGTTTCAGATCAACGTCTTCTTCTACA
CCATCCCCTTAGCCATAAAGCTAAAGGAGCACCCCATCTTCTTCATGTTTATCCAGATCGCTGTCATCGCCATCTTTAAGTCCTACCCGA
CAGTGGGGGACGTGGCGCTCTACATGGCCTTCTTCCCCGTGTGGAACCATCTCTACAGATTCCTGAGAAACATCTTTGTCCTCACCTGCA
TCATCATCGTCTGTTCCCTGCTCTTCCCTGTCCTGTGGCACCTCTGGATTTATGCAGGAAGTGCCAACTCTAATTTCTTTTATGCCATCA
CACTGACCTTCAACGTTGGGCAGATGGGCTTCTGTGGTGATAGAATGGCAGGTACTTGTCCTGAGGCCATCAGAGCTGCTGGTGACAGGA
CACCTTCCTGAACTCCTCCAGGCGCCTCTGATCTCTCCTTAGCTGCTGTTGTGTTACCTTCAGATCCTGCTCATCTCTGATTACTTCTAT
GCCTTCCTGCGGCGGGAGTACTACCTCACACATGGCCTCTACTTGACCGCCAAGGATGGCACAGAGGCCATGCTCGTGCTCAAGTAGGCC


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FusionGenePPI for FAM73A_PIGU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM73AELAVL1, COMTD1, PNKD, PTGER3, ARX, SIGLECL1, ERP44, NCR3LG1, EPHA1, TMEM206, CD70, ZNF555PIGUGPAA1, PIGS, PIGK, PIGT, HS2ST1, KITLG, NRG1, AGTR1, TXNDC15, B3GNT3, LYPD3, PRSS50, ERGIC3, GAL3ST1, FNDC4, LPAR1, GLRA2, PVRL4, CLEC5A, TCTN2, TCTN3, TMEM17, VNN2, SPPL2B, YIPF3, SLC6A15, CDH13, STOM


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM73A_PIGU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM73A_PIGU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource