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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12845

FusionGeneSummary for FAM65A_TANGO2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM65A_TANGO2
Fusion gene ID: 12845
HgeneTgene
Gene symbol

FAM65A

TANGO2

Gene ID

128989

Gene nametransport and golgi organization 2 homolog
SynonymsC22orf25|MECRCN
Cytomap

22q11.21

Type of geneprotein-coding
Descriptiontransport and Golgi organization protein 2 homolog
Modification date20180523
UniProtAcc

Q6ICL3

Ensembl transtripts involved in fusion geneENST00000379312, ENST00000566522, 
ENST00000042381, ENST00000540839, 
ENST00000422602, ENST00000428437, 
ENST00000401886, ENST00000447208, 
ENST00000398042, ENST00000432883, 
ENST00000327374, ENST00000479679, 
ENST00000401833, ENST00000434570, 
ENST00000420290, ENST00000456048, 
Fusion gene scores* DoF score5 X 6 X 3=904 X 2 X 4=32
# samples 54
** MAII scorelog2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM65A [Title/Abstract] AND TANGO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF818317FAM65Achr16

67575632

-TANGO2chr22

20052681

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000379312ENST00000401886FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000379312ENST00000447208FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000379312ENST00000398042FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000379312ENST00000432883FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000379312ENST00000327374FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000379312ENST00000479679FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000379312ENST00000401833FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000379312ENST00000434570FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000379312ENST00000420290FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000379312ENST00000456048FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-3UTRENST00000566522ENST00000401886FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-intronENST00000566522ENST00000447208FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-3UTRENST00000566522ENST00000398042FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-3UTRENST00000566522ENST00000432883FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-3UTRENST00000566522ENST00000327374FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-intronENST00000566522ENST00000479679FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-3UTRENST00000566522ENST00000401833FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-intronENST00000566522ENST00000434570FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-intronENST00000566522ENST00000420290FAM65Achr16

67575632

-TANGO2chr22

20052681

+
intron-3UTRENST00000566522ENST00000456048FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000042381ENST00000401886FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000042381ENST00000447208FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000042381ENST00000398042FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000042381ENST00000432883FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000042381ENST00000327374FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000042381ENST00000479679FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000042381ENST00000401833FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000042381ENST00000434570FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000042381ENST00000420290FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000042381ENST00000456048FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000540839ENST00000401886FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000540839ENST00000447208FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000540839ENST00000398042FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000540839ENST00000432883FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000540839ENST00000327374FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000540839ENST00000479679FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000540839ENST00000401833FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000540839ENST00000434570FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000540839ENST00000420290FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000540839ENST00000456048FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000422602ENST00000401886FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000422602ENST00000447208FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000422602ENST00000398042FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000422602ENST00000432883FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000422602ENST00000327374FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000422602ENST00000479679FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000422602ENST00000401833FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000422602ENST00000434570FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000422602ENST00000420290FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000422602ENST00000456048FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000428437ENST00000401886FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000428437ENST00000447208FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000428437ENST00000398042FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000428437ENST00000432883FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000428437ENST00000327374FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000428437ENST00000479679FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000428437ENST00000401833FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000428437ENST00000434570FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-intronENST00000428437ENST00000420290FAM65Achr16

67575632

-TANGO2chr22

20052681

+
5CDS-3UTRENST00000428437ENST00000456048FAM65Achr16

67575632

-TANGO2chr22

20052681

+

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FusionProtFeatures for FAM65A_TANGO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM65A

TANGO2

Q6ICL3

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM65A_TANGO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM65A_TANGO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM65A_TANGO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM65A_TANGO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTANGO2C4225171METABOLIC ENCEPHALOMYOPATHIC CRISES, RECURRENT, WITH RHABDOMYOLYSIS, CARDIAC ARRHYTHMIAS, AND NEURODEGENERATION1UNIPROT