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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12795

FusionGeneSummary for FAM35A_PAPSS2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM35A_PAPSS2
Fusion gene ID: 12795
HgeneTgene
Gene symbol

FAM35A

PAPSS2

Gene ID

9060

Gene name3'-phosphoadenosine 5'-phosphosulfate synthase 2
SynonymsATPSK2|BCYM4|SK2
Cytomap

10q23.2-q23.31

Type of geneprotein-coding
Descriptionbifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 23-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2ATP sulfurylase/APS kinase 2ATP sulfurylase/adenosine 5'-phosphosulfate kinasePAPS synthase 2PAPS synthetase 2SK 2adenosine 5'-ph
Modification date20180523
UniProtAcc

O95340

Ensembl transtripts involved in fusion geneENST00000298784, ENST00000298786, 
ENST00000361175, ENST00000456849, 
ENST00000427144, ENST00000482258, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 3 X 3=27
# samples 53
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM35A [Title/Abstract] AND PAPSS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-XR-A8TG-01AFAM35Achr10

88856746

+PAPSS2chr10

89500992

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000298784ENST00000361175FAM35Achr10

88856746

+PAPSS2chr10

89500992

+
5UTR-3CDSENST00000298784ENST00000456849FAM35Achr10

88856746

+PAPSS2chr10

89500992

+
5UTR-3CDSENST00000298784ENST00000427144FAM35Achr10

88856746

+PAPSS2chr10

89500992

+
5UTR-intronENST00000298784ENST00000482258FAM35Achr10

88856746

+PAPSS2chr10

89500992

+
5UTR-3CDSENST00000298786ENST00000361175FAM35Achr10

88856746

+PAPSS2chr10

89500992

+
5UTR-3CDSENST00000298786ENST00000456849FAM35Achr10

88856746

+PAPSS2chr10

89500992

+
5UTR-3CDSENST00000298786ENST00000427144FAM35Achr10

88856746

+PAPSS2chr10

89500992

+
5UTR-intronENST00000298786ENST00000482258FAM35Achr10

88856746

+PAPSS2chr10

89500992

+

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FusionProtFeatures for FAM35A_PAPSS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM35A

PAPSS2

O95340

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Bifunctional enzyme with both ATP sulfurylase and APSkinase activity, which mediates two steps in the sulfateactivation pathway. The first step is the transfer of a sulfategroup to ATP to yield adenosine 5'-phosphosulfate (APS), and thesecond step is the transfer of a phosphate group from ATP to APSyielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donorused by sulfotransferase). In mammals, PAPS is the sole source ofsulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesisduring postnatal growth (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM35A_PAPSS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM35A_PAPSS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM35AHNRNPA1, DEFA5, TRIM25PAPSS2VHL, APP, APEX1, ARIH2, HNRNPA2B1, GTF3C4, RIC8A, TUBB2A, TXNRD1, CTH, GSPT2, PAPSS1, WDR6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM35A_PAPSS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM35A_PAPSS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePAPSS2C2748515Spondyloepimetaphyseal Dysplasia, Pakistani Type2CTD_human;ORPHANET;UNIPROT