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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12776

FusionGeneSummary for FAM222B_HAO2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM222B_HAO2
Fusion gene ID: 12776
HgeneTgene
Gene symbol

FAM222B

HAO2

Gene ID

55731

51179

Gene namefamily with sequence similarity 222 member Bhydroxyacid oxidase 2
SynonymsC17orf63GIG16|HAOX2
Cytomap

17q11.2

1p12

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM222Buncharacterized protein C17orf63hydroxyacid oxidase 2(S)-2-hydroxy-acid oxidase, peroxisomalcell growth-inhibiting gene 16 proteinglycolate oxidasehydroxyacid oxidase 2 (long chain)long chain alpha-hydroxy acid oxidaselong-chain L-2-hydroxy acid oxidase
Modification date2018051920180523
UniProtAcc

Q8WU58

Q9NYQ3

Ensembl transtripts involved in fusion geneENST00000341217, ENST00000581407, 
ENST00000582266, ENST00000452648, 
ENST00000582059, ENST00000583953, 
ENST00000577682, ENST00000583522, 
ENST00000581381, 		ENST00000361035, 
ENST00000325945, ENST00000482991, 
Fusion gene scores* DoF score19 X 7 X 13=17293 X 3 X 2=18
# samples 224
** MAII scorelog2(22/1729*10)=-2.97436244011762
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM222B [Title/Abstract] AND HAO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHAO2

GO:0019395

fatty acid oxidation

10777549


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-XR-A8TG-01AFAM222Bchr17

27117396

-HAO2chr1

119934733

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341217ENST00000361035FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000341217ENST00000325945FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-intronENST00000341217ENST00000482991FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000581407ENST00000361035FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000581407ENST00000325945FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-intronENST00000581407ENST00000482991FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000582266ENST00000361035FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000582266ENST00000325945FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-intronENST00000582266ENST00000482991FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000452648ENST00000361035FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000452648ENST00000325945FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-intronENST00000452648ENST00000482991FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000582059ENST00000361035FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000582059ENST00000325945FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-intronENST00000582059ENST00000482991FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000583953ENST00000361035FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000583953ENST00000325945FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-intronENST00000583953ENST00000482991FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000577682ENST00000361035FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-3CDSENST00000577682ENST00000325945FAM222Bchr17

27117396

-HAO2chr1

119934733

+
intron-intronENST00000577682ENST00000482991FAM222Bchr17

27117396

-HAO2chr1

119934733

+
5UTR-3CDSENST00000583522ENST00000361035FAM222Bchr17

27117396

-HAO2chr1

119934733

+
5UTR-3CDSENST00000583522ENST00000325945FAM222Bchr17

27117396

-HAO2chr1

119934733

+
5UTR-intronENST00000583522ENST00000482991FAM222Bchr17

27117396

-HAO2chr1

119934733

+
5UTR-3CDSENST00000581381ENST00000361035FAM222Bchr17

27117396

-HAO2chr1

119934733

+
5UTR-3CDSENST00000581381ENST00000325945FAM222Bchr17

27117396

-HAO2chr1

119934733

+
5UTR-intronENST00000581381ENST00000482991FAM222Bchr17

27117396

-HAO2chr1

119934733

+

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FusionProtFeatures for FAM222B_HAO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM222B

Q8WU58

HAO2

Q9NYQ3

Catalyzes the oxidation of L-alpha-hydroxy acids as wellas, more slowly, that of L-alpha-amino acids.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM222B_HAO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM222B_HAO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM222BNLKHAO2PEX5, PPFIBP1, SMG6, PPM1A, RBPMS, RBPMS2, PM20D2, BCOR, ASPSCR1, TNIP1, CTAGE5, UBB, CYHR1, MIA3, ZNF703, WNK1, UBAP2, GSE1, STIP1, SF1, HSPA8, EIF4G3, TBL1X, TBL1XR1, TRIM33


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM222B_HAO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM222B_HAO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHAO2C0023893Liver Cirrhosis, Experimental2CTD_human
TgeneHAO2C4277682Chemical and Drug Induced Liver Injury1CTD_human