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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12769

FusionGeneSummary for FAM222B_C16orf62

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM222B_C16orf62
Fusion gene ID: 12769
HgeneTgene
Gene symbol

FAM222B

C16orf62

Gene ID

55731

Gene namefamily with sequence similarity 222 member B
SynonymsC17orf63
Cytomap

17q11.2

Type of geneprotein-coding
Descriptionprotein FAM222Buncharacterized protein C17orf63
Modification date20180519
UniProtAcc

Q8WU58

Q7Z3J2

Ensembl transtripts involved in fusion geneENST00000341217, ENST00000581407, 
ENST00000582266, ENST00000452648, 
ENST00000582059, ENST00000583953, 
ENST00000577682, ENST00000583522, 
ENST00000581381, 		ENST00000438132, 
ENST00000542263, ENST00000417362, 
ENST00000251143, ENST00000543152, 
ENST00000448695, ENST00000544275, 
ENST00000538853, 
Fusion gene scores* DoF score19 X 7 X 13=172910 X 8 X 7=560
# samples 2214
** MAII scorelog2(22/1729*10)=-2.97436244011762
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/560*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM222B [Title/Abstract] AND C16orf62 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-09-1659-01BFAM222Bchr17

27169700

-C16orf62chr16

19627436

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000341217ENST00000438132FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000341217ENST00000542263FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000341217ENST00000417362FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000341217ENST00000251143FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000341217ENST00000543152FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000341217ENST00000448695FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000341217ENST00000544275FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000341217ENST00000538853FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-3CDSENST00000581407ENST00000438132FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581407ENST00000542263FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581407ENST00000417362FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581407ENST00000251143FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581407ENST00000543152FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581407ENST00000448695FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581407ENST00000544275FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581407ENST00000538853FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-3CDSENST00000582266ENST00000438132FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000582266ENST00000542263FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000582266ENST00000417362FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000582266ENST00000251143FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000582266ENST00000543152FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000582266ENST00000448695FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000582266ENST00000544275FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000582266ENST00000538853FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-3CDSENST00000452648ENST00000438132FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000452648ENST00000542263FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000452648ENST00000417362FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000452648ENST00000251143FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000452648ENST00000543152FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000452648ENST00000448695FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000452648ENST00000544275FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000452648ENST00000538853FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-3CDSENST00000582059ENST00000438132FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000582059ENST00000542263FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000582059ENST00000417362FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000582059ENST00000251143FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000582059ENST00000543152FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000582059ENST00000448695FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000582059ENST00000544275FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000582059ENST00000538853FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-3CDSENST00000583953ENST00000438132FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000583953ENST00000542263FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000583953ENST00000417362FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000583953ENST00000251143FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000583953ENST00000543152FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000583953ENST00000448695FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000583953ENST00000544275FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
intron-intronENST00000583953ENST00000538853FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-3CDSENST00000577682ENST00000438132FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000577682ENST00000542263FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000577682ENST00000417362FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000577682ENST00000251143FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000577682ENST00000543152FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000577682ENST00000448695FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000577682ENST00000544275FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000577682ENST00000538853FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-3CDSENST00000583522ENST00000438132FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000583522ENST00000542263FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000583522ENST00000417362FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000583522ENST00000251143FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000583522ENST00000543152FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000583522ENST00000448695FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000583522ENST00000544275FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000583522ENST00000538853FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-3CDSENST00000581381ENST00000438132FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581381ENST00000542263FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581381ENST00000417362FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581381ENST00000251143FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581381ENST00000543152FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581381ENST00000448695FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581381ENST00000544275FAM222Bchr17

27169700

-C16orf62chr16

19627436

+
5UTR-intronENST00000581381ENST00000538853FAM222Bchr17

27169700

-C16orf62chr16

19627436

+

Top

FusionProtFeatures for FAM222B_C16orf62


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM222B

Q8WU58

C16orf62

Q7Z3J2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAM222B_C16orf62


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAM222B_C16orf62


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM222BNLKC16orf62CCDC22, CCDC93, COMMD1, BSG, COMMD3, COMMD4, DCUN1D1, TRIM25, NTRK1, COMMD6, VPS29, COMMD2, COMMD10, COMMD8, FAM45A, HDAC11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM222B_C16orf62


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM222B_C16orf62


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource