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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12758

FusionGeneSummary for FAM219A_ISLR

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM219A_ISLR
Fusion gene ID: 12758
HgeneTgene
Gene symbol

FAM219A

ISLR

Gene ID

203259

3671

Gene namefamily with sequence similarity 219 member Aimmunoglobulin superfamily containing leucine rich repeat
SynonymsC9orf25HsT17563|Meflin
Cytomap

9p13.3

15q24.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM219Auncharacterized protein C9orf25immunoglobulin superfamily containing leucine-rich repeat proteinmesenchymal stromal cell- and fibroblast-expressing Linx paralogue
Modification date2018051920180519
UniProtAcc

Q8IW50

O14498

Ensembl transtripts involved in fusion geneENST00000379081, ENST00000379087, 
ENST00000379080, ENST00000379084, 
ENST00000379089, ENST00000445726, 
ENST00000297620, ENST00000379078, 
ENST00000249842, ENST00000395118, 
Fusion gene scores* DoF score6 X 4 X 4=964 X 3 X 1=12
# samples 76
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/12*10)=2.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM219A [Title/Abstract] AND ISLR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE707994FAM219Achr9

34426791

-ISLRchr15

74468481

-
ChiTaRS3.1BE707974FAM219Achr9

34426791

-ISLRchr15

74468481

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000379081ENST00000249842FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379081ENST00000395118FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379087ENST00000249842FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379087ENST00000395118FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379080ENST00000249842FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379080ENST00000395118FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379084ENST00000249842FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379084ENST00000395118FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379089ENST00000249842FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379089ENST00000395118FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000445726ENST00000249842FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000445726ENST00000395118FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000297620ENST00000249842FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000297620ENST00000395118FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379078ENST00000249842FAM219Achr9

34426791

-ISLRchr15

74468481

-
intron-3CDSENST00000379078ENST00000395118FAM219Achr9

34426791

-ISLRchr15

74468481

-

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FusionProtFeatures for FAM219A_ISLR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM219A

Q8IW50

ISLR

O14498


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM219A_ISLR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM219A_ISLR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM219A_ISLR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM219A_ISLR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource