	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 12751

FusionGeneSummary for FAM214B_FAM214B

Fusion gene summary

Fusion gene information	Fusion gene name: FAM214B_FAM214B
	Fusion gene ID: 12751
		Hgene	Tgene
	Gene symbol	FAM214B	FAM214B
	Gene ID	80256	80256
	Gene name	family with sequence similarity 214 member B	family with sequence similarity 214 member B
	Synonyms	KIAA1539	KIAA1539
	Cytomap	9p13.3	9p13.3
	Type of gene	protein-coding	protein-coding
	Description	protein FAM214B	protein FAM214B
	Modification date	20180522	20180522
	UniProtAcc	Q7L5A3	Q7L5A3
	Ensembl transtripts involved in fusion gene	ENST00000378566, ENST00000603301, ENST00000488109, ENST00000322813, ENST00000605244, ENST00000378561, ENST00000378557, ENST00000378554, ENST00000605392,	ENST00000378566, ENST00000603301, ENST00000488109, ENST00000322813, ENST00000605244, ENST00000378561, ENST00000378557, ENST00000378554, ENST00000605392,
Fusion gene scores	* DoF score	2 X 2 X 2=8	3 X 2 X 3=18
	# samples	2	3
	** MAII score	log2(2/8*10)=1.32192809488736	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FAM214B [Title/Abstract] AND FAM214B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA224906	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000378566	ENST00000378566	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378566	ENST00000603301	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378566	ENST00000488109	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378566	ENST00000322813	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378566	ENST00000605244	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378566	ENST00000378561	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378566	ENST00000378557	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000378566	ENST00000378554	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000378566	ENST00000605392	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000603301	ENST00000378566	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000603301	ENST00000603301	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000603301	ENST00000488109	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000603301	ENST00000322813	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000603301	ENST00000605244	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000603301	ENST00000378561	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000603301	ENST00000378557	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000603301	ENST00000378554	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000603301	ENST00000605392	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000488109	ENST00000378566	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000488109	ENST00000603301	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000488109	ENST00000488109	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000488109	ENST00000322813	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000488109	ENST00000605244	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000488109	ENST00000378561	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000488109	ENST00000378557	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000488109	ENST00000378554	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000488109	ENST00000605392	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000322813	ENST00000378566	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000322813	ENST00000603301	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000322813	ENST00000488109	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000322813	ENST00000322813	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000322813	ENST00000605244	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000322813	ENST00000378561	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000322813	ENST00000378557	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000322813	ENST00000378554	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000322813	ENST00000605392	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605244	ENST00000378566	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605244	ENST00000603301	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605244	ENST00000488109	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605244	ENST00000322813	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605244	ENST00000605244	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605244	ENST00000378561	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605244	ENST00000378557	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000605244	ENST00000378554	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000605244	ENST00000605392	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378561	ENST00000378566	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378561	ENST00000603301	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378561	ENST00000488109	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378561	ENST00000322813	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378561	ENST00000605244	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378561	ENST00000378561	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378561	ENST00000378557	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000378561	ENST00000378554	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000378561	ENST00000605392	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378557	ENST00000378566	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378557	ENST00000603301	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378557	ENST00000488109	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378557	ENST00000322813	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378557	ENST00000605244	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378557	ENST00000378561	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378557	ENST00000378557	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000378557	ENST00000378554	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000378557	ENST00000605392	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378554	ENST00000378566	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378554	ENST00000603301	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378554	ENST00000488109	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378554	ENST00000322813	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378554	ENST00000605244	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378554	ENST00000378561	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000378554	ENST00000378557	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000378554	ENST00000378554	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000378554	ENST00000605392	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605392	ENST00000378566	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605392	ENST00000603301	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605392	ENST00000488109	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605392	ENST00000322813	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605392	ENST00000605244	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605392	ENST00000378561	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-3UTR	ENST00000605392	ENST00000378557	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000605392	ENST00000378554	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+
intron-intron	ENST00000605392	ENST00000605392	FAM214B	chr9	35104959	-	FAM214B	chr9	35105007	+

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FusionProtFeatures for FAM214B_FAM214B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FAM214B Q7L5A3	FAM214B Q7L5A3

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for FAM214B_FAM214B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM214B_FAM214B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for FAM214B_FAM214B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FAM214B_FAM214B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 12751

FusionGeneSummary for FAM214B_FAM214B

FusionProtFeatures for FAM214B_FAM214B

FusionGeneSequence for FAM214B_FAM214B

FusionGenePPI for FAM214B_FAM214B

RelatedDrugs for FAM214B_FAM214B

RelatedDiseases for FAM214B_FAM214B