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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12732

FusionGeneSummary for FAM20B_CRK

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM20B_CRK
Fusion gene ID: 12732
HgeneTgene
Gene symbol

FAM20B

CRK

Gene ID

9917

1398

Gene nameFAM20B, glycosaminoglycan xylosylkinaseCRK proto-oncogene, adaptor protein
Synonymsgxk1CRKII|p38
Cytomap

1q25.2

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionglycosaminoglycan xylosylkinasefamily with sequence similarity 20, member Bxylose kinaseadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein
Modification date2018052320180522
UniProtAcc

O75063

P46108

Ensembl transtripts involved in fusion geneENST00000263733, ENST00000398970, 
ENST00000300574, ENST00000574295, 
ENST00000572145, 
Fusion gene scores* DoF score5 X 6 X 3=908 X 8 X 2=128
# samples 68
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM20B [Title/Abstract] AND CRK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCRK

GO:0009966

regulation of signal transduction

17515907

TgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

TgeneCRK

GO:0043087

regulation of GTPase activity

11870224

TgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

TgeneCRK

GO:0061045

negative regulation of wound healing

17515907

TgeneCRK

GO:0071538

SH2 domain-mediated complex assembly

12384576

TgeneCRK

GO:2000146

negative regulation of cell motility

17515907


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE706868FAM20Bchr1

179041524

+CRKchr17

1357030

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000263733ENST00000398970FAM20Bchr1

179041524

+CRKchr17

1357030

-
3UTR-intronENST00000263733ENST00000300574FAM20Bchr1

179041524

+CRKchr17

1357030

-
3UTR-intronENST00000263733ENST00000574295FAM20Bchr1

179041524

+CRKchr17

1357030

-
3UTR-intronENST00000263733ENST00000572145FAM20Bchr1

179041524

+CRKchr17

1357030

-

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FusionProtFeatures for FAM20B_CRK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM20B

O75063

CRK

P46108

Responsible for the 2-O-phosphorylation of xylose in theglycosaminoglycan-protein linkage region of proteoglycans therebyregulating the amount of mature GAG chains. Sulfatedglycosaminoglycans (GAGs), including heparan sulfate andchondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise additionof monosaccharide residues by the respective specificglycosyltransferases. Xylose 2-O-phosphorylation may influence thecatalytic activity of B3GAT3 (GlcAT-I) which completes theprecursor tetrasaccharide of GAG-protein linkage regions on whichthe repeating disaccharide region is synthesized.{ECO:0000269|PubMed:19473117, ECO:0000269|PubMed:24425863}. Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM20B_CRK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM20B_CRK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM20B_CRK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM20B_CRK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCRKC0151744Myocardial Ischemia1CTD_human