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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12725

FusionGeneSummary for FAM208B_AKR1E2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM208B_AKR1E2
Fusion gene ID: 12725
HgeneTgene
Gene symbol

FAM208B

AKR1E2

Gene ID

54906

83592

Gene namefamily with sequence similarity 208 member Baldo-keto reductase family 1 member E2
SynonymsC10orf18|bA318E3.2AKR1CL2|AKRDC1|LoopADR|TAKR|hTSP|htAKR
Cytomap

10p15.1

10p15.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM208B1,5-anhydro-D-fructose reductaseAF reductasealdo-keto reductase family 1 member C-like protein 2aldo-keto reductase family 1, member C-like 2aldo-keto reductase loopADRtestis aldo-keto reductasetestis-specific protein
Modification date2018052220180523
UniProtAcc

Q5VWN6

Q96JD6

Ensembl transtripts involved in fusion geneENST00000328090, ENST00000463468, 
ENST00000298375, ENST00000525281, 
ENST00000532248, ENST00000334019, 
ENST00000345253, 
Fusion gene scores* DoF score5 X 4 X 5=1005 X 2 X 5=50
# samples 86
** MAII scorelog2(8/100*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM208B [Title/Abstract] AND AKR1E2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAKR1E2

GO:0055114

oxidation-reduction process

15118078


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-XF-A8HD-01AFAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000328090ENST00000298375FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
5UTR-3UTRENST00000328090ENST00000525281FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
5UTR-3UTRENST00000328090ENST00000532248FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
5UTR-3UTRENST00000328090ENST00000334019FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
5UTR-3UTRENST00000328090ENST00000345253FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
intron-3CDSENST00000463468ENST00000298375FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
intron-3UTRENST00000463468ENST00000525281FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
intron-3UTRENST00000463468ENST00000532248FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
intron-3UTRENST00000463468ENST00000334019FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+
intron-3UTRENST00000463468ENST00000345253FAM208Bchr10

5727138

+AKR1E2chr10

4872867

+

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FusionProtFeatures for FAM208B_AKR1E2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM208B

Q5VWN6

AKR1E2

Q96JD6

Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has lowNADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078).{ECO:0000250|UniProtKB:Q9DCT1, ECO:0000269|PubMed:12604216,ECO:0000269|PubMed:15118078}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM208B_AKR1E2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM208B_AKR1E2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM208BCCDC85B, LDOC1, FAM208B, SIRT7, NFX1, CUL3, PRKAB2, TRIM23, CCNG2, ERH, LMO1, SCAMP1, POLR1C, NEK6, PPP1R16B, KCTD9, CARD9, ATRIP, FBF1, KLHL40, MORN3, TRIM42, ZNF200, ZNF597, STAT3, COX5B, MPHOSPH8, IRF2, L3MBTL1, HNRNPLL, NCAPH2, SIRT6, SMARCB1AKR1E2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM208B_AKR1E2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM208B_AKR1E2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource