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Fusion gene ID: 12724 |
FusionGeneSummary for FAM208A_TADA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM208A_TADA3 | Fusion gene ID: 12724 | Hgene | Tgene | Gene symbol | FAM208A | TADA3 | Gene ID | 23272 | 10474 |
| Gene name | family with sequence similarity 208 member A | transcriptional adaptor 3 | |
| Synonyms | C3orf63|RAP140|TASOR|se89-1 | ADA3|NGG1|STAF54|TADA3L|hADA3 | |
| Cytomap | 3p14.3 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein TASORCTCL tumor antigen se89-1protein FAM208Aretinoblastoma-associated protein 140retinoblastoma-associated protein RAP140transgene activation suppressor protein | transcriptional adapter 3ADA3 homologADA3-like proteinalteration/deficiency in activation 3 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UK61 | O75528 | |
| Ensembl transtripts involved in fusion gene | ENST00000431842, ENST00000493960, ENST00000355628, ENST00000485156, | ENST00000301964, ENST00000440161, ENST00000343450, ENST00000492635, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 3 X 3=36 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FAM208A [Title/Abstract] AND TADA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TADA3 | GO:0043966 | histone H3 acetylation | 11564863|18838386 |
| Tgene | TADA3 | GO:0045893 | positive regulation of transcription, DNA-templated | 20413580 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-AX-A3FW-01A | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000431842 | ENST00000301964 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-5UTR | ENST00000431842 | ENST00000440161 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-5UTR | ENST00000431842 | ENST00000343450 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-intron | ENST00000431842 | ENST00000492635 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-5UTR | ENST00000493960 | ENST00000301964 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-5UTR | ENST00000493960 | ENST00000440161 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-5UTR | ENST00000493960 | ENST00000343450 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-intron | ENST00000493960 | ENST00000492635 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-5UTR | ENST00000355628 | ENST00000301964 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-5UTR | ENST00000355628 | ENST00000440161 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-5UTR | ENST00000355628 | ENST00000343450 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| 5CDS-intron | ENST00000355628 | ENST00000492635 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| intron-5UTR | ENST00000485156 | ENST00000301964 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| intron-5UTR | ENST00000485156 | ENST00000440161 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| intron-5UTR | ENST00000485156 | ENST00000343450 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
| intron-intron | ENST00000485156 | ENST00000492635 | FAM208A | chr3 | 56694759 | - | TADA3 | chr3 | 9833177 | - |
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FusionProtFeatures for FAM208A_TADA3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM208A | TADA3 |
| Component of the HUSH complex, a multiprotein complexthat mediates epigenetic repression. The HUSH complex is recruitedto genomic loci rich in H3K9me3 and is probably required tomaintain transcriptional silencing by promoting recruitment ofSETDB1, a histone methyltransferase that mediates furtherdeposition of H3K9me3. {ECO:0000269|PubMed:26022416}. | Functions as a component of the PCAF complex. The PCAFcomplex is capable of efficiently acetylating histones in anucleosomal context. The PCAF complex could be considered as thehuman version of the yeast SAGA complex. Also known as acoactivator for p53/TP53-dependent transcriptional activation.Component of the ATAC complex, a complex with histoneacetyltransferase activity on histones H3 and H4.{ECO:0000269|PubMed:11707411, ECO:0000269|PubMed:19103755}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM208A_TADA3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM208A_TADA3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FAM208A | ELAVL1, AP2M1, EZH2, SUZ12, RNF2, BMI1, ZCCHC7, HPS1, SKAP1, CORO1A, IFI16, B9D2, DYNLT1, MATR3, MPHOSPH8, USP37, RB1, KLHL40, FAM131B, HNRNPLL, CDC16, BBS7, IQCF1, SSSCA1, IL17RA, TRIM25 | TADA3 | CCDC101, USP5, TADA2A, EP300, TP53, EIF3J, HSPA8, RFX1, ZNF7, SAP18, RARA, RXRA, ESR1, SUPT3H, TAF9, USP22, TAF10, ATXN7, ANKRD12, KAT2B, KAT2A, CTNNB1, AR, TXNRD2, NR1I2, SREBF1, PIAS4, ING5, MAGEH1, XRCC6, YEATS2, DR1, MBIP, WDR5, MAP3K7, TAF5L, NUP205, KDM1A, CCNC, HEXIM2, HIST3H3, MAGEA10, TADA2B, ATXN7L3, CSRP2BP, SUPT20H, ZZZ3, HAUS1, TRRAP, TADA1, TAF9B, ATF7IP, TAF12, SPATA20, HAUS4, TAF6L, BCAS2, SUPT7L, KPNA1, LIMK1, MYO1C, MED12, SETD4, BRD2, IKZF5, CDH19, CARD8, ATXN7L3B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM208A_TADA3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM208A_TADA3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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