FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12715

FusionGeneSummary for FAM19A5_UBE3B

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM19A5_UBE3B
Fusion gene ID: 12715
HgeneTgene
Gene symbol

FAM19A5

UBE3B

Gene ID

25817

89910

Gene namefamily with sequence similarity 19 member A5, C-C motif chemokine likeubiquitin protein ligase E3B
SynonymsQLLK5208|TAFA-5|TAFA5|UNQ5208BPIDS|KOS
Cytomap

22q13.32

12q24.11

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM19A5TAFA protein 5chemokine-like protein TAFA-5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5ubiquitin-protein ligase E3BHECT-type ubiquitin transferase E3B
Modification date2018032920180523
UniProtAcc

Q7Z5A7

Q7Z3V4

Ensembl transtripts involved in fusion geneENST00000402357, ENST00000358295, 
ENST00000473898, ENST00000406880, 
ENST00000434735, ENST00000342494, 
ENST00000535089, ENST00000280774, 
ENST00000536398, ENST00000340074, 
ENST00000540230, ENST00000537063, 
ENST00000535900, 
Fusion gene scores* DoF score8 X 5 X 4=1603 X 3 X 3=27
# samples 73
** MAII scorelog2(7/160*10)=-1.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM19A5 [Title/Abstract] AND UBE3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE066493FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000402357ENST00000434735FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000402357ENST00000342494FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000402357ENST00000535089FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000402357ENST00000280774FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000402357ENST00000536398FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000402357ENST00000340074FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000402357ENST00000540230FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000402357ENST00000537063FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000402357ENST00000535900FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000358295ENST00000434735FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000358295ENST00000342494FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000358295ENST00000535089FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000358295ENST00000280774FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000358295ENST00000536398FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000358295ENST00000340074FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000358295ENST00000540230FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000358295ENST00000537063FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000358295ENST00000535900FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000473898ENST00000434735FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000473898ENST00000342494FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000473898ENST00000535089FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000473898ENST00000280774FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000473898ENST00000536398FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000473898ENST00000340074FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000473898ENST00000540230FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000473898ENST00000537063FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000473898ENST00000535900FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000406880ENST00000434735FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000406880ENST00000342494FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000406880ENST00000535089FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000406880ENST00000280774FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000406880ENST00000536398FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000406880ENST00000340074FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000406880ENST00000540230FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000406880ENST00000537063FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-
intron-intronENST00000406880ENST00000535900FAM19A5chr22

49090610

+UBE3Bchr12

109955091

-

Top

FusionProtFeatures for FAM19A5_UBE3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM19A5

Q7Z5A7

UBE3B

Q7Z3V4

E3 ubiquitin-protein ligase which accepts ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAM19A5_UBE3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAM19A5_UBE3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM19A5_UBE3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM19A5_UBE3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUBE3BC1855663Kaufman oculocerebrofacial syndrome1ORPHANET;UNIPROT