|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 12712 |
FusionGeneSummary for FAM19A5_MCAT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM19A5_MCAT | Fusion gene ID: 12712 | Hgene | Tgene | Gene symbol | FAM19A5 | MCAT | Gene ID | 25817 | 27349 |
| Gene name | family with sequence similarity 19 member A5, C-C motif chemokine like | malonyl-CoA-acyl carrier protein transacylase | |
| Synonyms | QLLK5208|TAFA-5|TAFA5|UNQ5208 | FASN2C|MCT|MCT1|MT|NET62|fabD | |
| Cytomap | 22q13.32 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM19A5TAFA protein 5chemokine-like protein TAFA-5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 | malonyl-CoA-acyl carrier protein transacylase, mitochondrial[Acyl-carrier-protein] malonyltransferase[acyl-carrier-protein] S-malonyltransferasemalonyl CoA:ACP acyltransferase (mitochondrial)mitochondrial malonyl CoA:ACP acyltransferasemitochondrial | |
| Modification date | 20180329 | 20180519 | |
| UniProtAcc | Q7Z5A7 | Q8IVS2 | |
| Ensembl transtripts involved in fusion gene | ENST00000402357, ENST00000358295, ENST00000473898, ENST00000406880, | ENST00000290429, ENST00000327555, ENST00000464244, | |
| Fusion gene scores | * DoF score | 8 X 5 X 4=160 | 4 X 3 X 4=48 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/160*10)=-1.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM19A5 [Title/Abstract] AND MCAT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MCAT | GO:0006633 | fatty acid biosynthetic process | 12882974 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-FS-A4F4-06A | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000402357 | ENST00000290429 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| intron-intron | ENST00000402357 | ENST00000327555 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| intron-intron | ENST00000402357 | ENST00000464244 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| In-frame | ENST00000358295 | ENST00000290429 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| 5CDS-intron | ENST00000358295 | ENST00000327555 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| 5CDS-intron | ENST00000358295 | ENST00000464244 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| 3UTR-3CDS | ENST00000473898 | ENST00000290429 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| 3UTR-intron | ENST00000473898 | ENST00000327555 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| 3UTR-intron | ENST00000473898 | ENST00000464244 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| intron-3CDS | ENST00000406880 | ENST00000290429 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| intron-intron | ENST00000406880 | ENST00000327555 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
| intron-intron | ENST00000406880 | ENST00000464244 | FAM19A5 | chr22 | 48972383 | + | MCAT | chr22 | 43533304 | - |
Top |
FusionProtFeatures for FAM19A5_MCAT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM19A5 | MCAT |
| Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of themitochondrial ACP protein (NDUFAB1). This suggests the existenceof the biosynthesis of fatty acids in mitochondria.{ECO:0000269|PubMed:12882974}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FAM19A5_MCAT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FAM19A5_ENST00000358295_chr22_48972383_+_MCAT_ENST00000290429_chr22_43533304_-_251aa MQLLKALWALAGAALCCFLVLVIHAQFLKEGLYAVKIRAEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIENPVCEVSNY LFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAVDIKKPLVSVYSNVHAHRYRHPGHIHKLLAQQL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FAM19A5_ENST00000358295_chr22_48972383_+_MCAT_ENST00000290429_chr22_43533304_-_753nt ATGCAGCTCCTGAAGGCGCTCTGGGCACTGGCAGGGGCCGCGCTCTGCTGCTTCCTCGTCCTAGTGATCCACGCGCAGTTCCTCAAAGAA GGTTTGTATGCAGTGAAAATCCGAGCTGAGGCCATGCAGGAAGCTTCAGAAGCTGTCCCCAGTGGGATGCTGTCTGTCCTCGGCCAGCCT CAGTCCAAGTTCAACTTCGCCTGTTTGGAAGCCCGGGAACACTGCAAGTCTTTAGGCATAGAGAACCCCGTATGTGAAGTGTCCAACTAC CTCTTTCCAGATTGCAGGGTGATTTCAGGACACCAAGAGGCTCTACGGTTTCTCCAGAAGAATTCCTCTAAGTTTCATTTCAGACGCACC AGGATGTTGCCGGTTAGTGGCGCATTCCACACCCGCCTCATGGAGCCAGCCGTGGAGCCCCTGACGCAAGCTTTAAAGGCAGTCGACATT AAGAAGCCTCTGGTTTCTGTCTACTCCAACGTCCACGCGCATAGATACAGGCATCCCGGGCACATCCACAAGCTGCTGGCCCAGCAGCTG GTCTCCCCAGTGAAGTGGGAGCAGACGATGCATGCCATATACGAAAGGAAAAAGGGCAGGGGGTTCCCCCAAACTTTCGAAGTAGGCCCT GGCAGGCAGCTGGGAGCCATCCTGAAGAGCTGTAACATGCAGGCCTGGAAGTCCTACAGCGCCGTGGATGTGCTGCAGACCCTCGAACAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FAM19A5_ENST00000358295_chr22_48972383_+_MCAT_ENST00000290429_chr22_43533304_-_1765nt AAAGACACAAATCGCCTCCCGGAGTGGCGCCTCCAGTCGCGGCGGAGCGCGGCGTTGGCGGCGGATGGAGGGCGCGAGCGGGCGGCCGCG GAGGCTGCACCCGGCGGGGCGCTGATGCGGCGCCTGGACCTTCGCTGCGCGACTTCGGGGGCGTCGGCCGAGTTGGGACTCCGCGATGCA GCTCCTGAAGGCGCTCTGGGCACTGGCAGGGGCCGCGCTCTGCTGCTTCCTCGTCCTAGTGATCCACGCGCAGTTCCTCAAAGAAGGTTT GTATGCAGTGAAAATCCGAGCTGAGGCCATGCAGGAAGCTTCAGAAGCTGTCCCCAGTGGGATGCTGTCTGTCCTCGGCCAGCCTCAGTC CAAGTTCAACTTCGCCTGTTTGGAAGCCCGGGAACACTGCAAGTCTTTAGGCATAGAGAACCCCGTATGTGAAGTGTCCAACTACCTCTT TCCAGATTGCAGGGTGATTTCAGGACACCAAGAGGCTCTACGGTTTCTCCAGAAGAATTCCTCTAAGTTTCATTTCAGACGCACCAGGAT GTTGCCGGTTAGTGGCGCATTCCACACCCGCCTCATGGAGCCAGCCGTGGAGCCCCTGACGCAAGCTTTAAAGGCAGTCGACATTAAGAA GCCTCTGGTTTCTGTCTACTCCAACGTCCACGCGCATAGATACAGGCATCCCGGGCACATCCACAAGCTGCTGGCCCAGCAGCTGGTCTC CCCAGTGAAGTGGGAGCAGACGATGCATGCCATATACGAAAGGAAAAAGGGCAGGGGGTTCCCCCAAACTTTCGAAGTAGGCCCTGGCAG GCAGCTGGGAGCCATCCTGAAGAGCTGTAACATGCAGGCCTGGAAGTCCTACAGCGCCGTGGATGTGCTGCAGACCCTCGAACATGTGGA CCTGGACCCTCAGGAGCCCCCGAGATGACTGCAGGGGGCTCAAATGCGATGACCCCCTCTGTCCTCCTGAGGAGAGGCTGTAGGCTGTGC CTGTCGCCCCCTACCTTCCTAATGGCTCCTCCTCTGAGGAGTGAAAGGGATTTGTTTGCAACGTGCTTTGAAGGCCACATAAAAAGCCCT AAAAATGAGTATTTCTTTACATGACCCAGTCCATTTCTCCCCCTTGGAAAAACGTTTGGACGTTGGGAAGAATGATGCCACAGGGCTGGT GTGTGGGGAAGCTAGAATCCTGGCCCCGCCTCTGCCAGCCCTGCACCATAGGCAGGTGTGCCATCTCAGCGGGAAGGGGAGGACTGGCTG CTGCAGCCTGTCCTGCTCTGTGAGTGCTGAGAACATGCTGGTGTGGCCTCAATTTCAGCCAGTGCCAGGGGAGCCCCTCCACCACCCCCA GCCTGCCCCCCAGGGCTCCTTTGTCACAAATCTGAAAGGTTTTAGAACCCAGTTGGCCTTGGCAGTTTTGTTCACCTCCTCACTTGACAG CTGGGAGACAGAGGCCCACATTTATGGACATACCCAAGAGATATGTATTGCCTGCTGTGTGCTAGAGAGTGAGTGCGCTCTGTTCTGGTA GAAAGGTCCTTGAGTGAGGTGCGGGGTGTGGGGAGTGCCAGGTAGGGAGGGCGACTGAGGCCCTGGTCCTAGGGGTGGAACCATGGAGGA ACACCCTGGTCACCCACTGGGACTGCGGGTCTGCGGGGCGCCAGAGGGAGCACAGCACATACCTGCCTCGGAGCTGACCCCTGGCTCCAT |
Top |
FusionGenePPI for FAM19A5_MCAT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FAM19A5 | MCAT | ICT1, MRPS16, ITGAV, SPCS2, PTPN1, RAVER1, SPTAN1, SHMT1, EWSR1, TAP1, AGMAT, TMEM43, HNRNPDL, MRPL4, HNRNPA1, MRPL39, POLR2M, RBMX, ERAL1, RPUSD2, MYC, RXRB, REEP5, TFEB, SLC33A1, MMGT1, USF1, ALAS1, TAF5, RBM3, ZNF324B, DDX28, MRPS34, METTL17, MRPS15, ZYG11B, MRPS11, MALSU1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FAM19A5_MCAT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FAM19A5_MCAT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MCAT | C0036341 | Schizophrenia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|