FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12679

FusionGeneSummary for FAM192A_C16orf62

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM192A_C16orf62
Fusion gene ID: 12679
HgeneTgene
Gene symbol

FAM192A

C16orf62

Gene ID

80011

Gene namefamily with sequence similarity 192 member A
SynonymsC16orf94|CDA018|CDA10|NIP30
Cytomap

16q13

Type of geneprotein-coding
Descriptionprotein FAM192ANEFA-interacting nuclear protein NIP30
Modification date20180519
UniProtAcc

Q9GZU8

Q7Z3J2

Ensembl transtripts involved in fusion geneENST00000309137, ENST00000389447, 
ENST00000566077, ENST00000569266, 
ENST00000567439, ENST00000564108, 
ENST00000562400, 		ENST00000438132, 
ENST00000542263, ENST00000417362, 
ENST00000251143, ENST00000543152, 
ENST00000448695, ENST00000544275, 
ENST00000538853, 
Fusion gene scores* DoF score3 X 3 X 3=2710 X 8 X 7=560
# samples 314
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(14/560*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM192A [Title/Abstract] AND C16orf62 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0RX-01AFAM192Achr16

57219733

-C16orf62chr16

19663298

+
TCGALDBRCATCGA-BH-A0RX-01AFAM192Achr16

57219943

-C16orf62chr16

19663298

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000309137ENST00000438132FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000309137ENST00000542263FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000309137ENST00000417362FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000309137ENST00000251143FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000309137ENST00000543152FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000309137ENST00000448695FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3UTRENST00000309137ENST00000544275FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-intronENST00000309137ENST00000538853FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000438132FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000542263FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000417362FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000251143FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000543152FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000448695FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3UTRENST00000389447ENST00000544275FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-intronENST00000389447ENST00000538853FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000566077ENST00000438132FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000566077ENST00000542263FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000566077ENST00000417362FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000566077ENST00000251143FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000566077ENST00000543152FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000566077ENST00000448695FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3UTRENST00000566077ENST00000544275FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-intronENST00000566077ENST00000538853FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000438132FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000542263FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000417362FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000251143FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000543152FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000448695FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3UTRENST00000569266ENST00000544275FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-intronENST00000569266ENST00000538853FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000567439ENST00000438132FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000567439ENST00000542263FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000567439ENST00000417362FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000567439ENST00000251143FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000567439ENST00000543152FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000567439ENST00000448695FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3UTRENST00000567439ENST00000544275FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-intronENST00000567439ENST00000538853FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000564108ENST00000438132FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000564108ENST00000542263FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000564108ENST00000417362FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000564108ENST00000251143FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000564108ENST00000543152FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3CDSENST00000564108ENST00000448695FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-3UTRENST00000564108ENST00000544275FAM192Achr16

57219733

-C16orf62chr16

19663298

+
5UTR-intronENST00000564108ENST00000538853FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000438132FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000542263FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000417362FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000251143FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000543152FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000448695FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3UTRENST00000562400ENST00000544275FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-intronENST00000562400ENST00000538853FAM192Achr16

57219733

-C16orf62chr16

19663298

+
intron-3CDSENST00000309137ENST00000438132FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000309137ENST00000542263FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000309137ENST00000417362FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000309137ENST00000251143FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000309137ENST00000543152FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000309137ENST00000448695FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3UTRENST00000309137ENST00000544275FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-intronENST00000309137ENST00000538853FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000438132FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000542263FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000417362FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000251143FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000543152FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000389447ENST00000448695FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3UTRENST00000389447ENST00000544275FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-intronENST00000389447ENST00000538853FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000566077ENST00000438132FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000566077ENST00000542263FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000566077ENST00000417362FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000566077ENST00000251143FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000566077ENST00000543152FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000566077ENST00000448695FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3UTRENST00000566077ENST00000544275FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-intronENST00000566077ENST00000538853FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000438132FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000542263FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000417362FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000251143FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000543152FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000569266ENST00000448695FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3UTRENST00000569266ENST00000544275FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-intronENST00000569266ENST00000538853FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000567439ENST00000438132FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000567439ENST00000542263FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000567439ENST00000417362FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000567439ENST00000251143FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000567439ENST00000543152FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000567439ENST00000448695FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3UTRENST00000567439ENST00000544275FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-intronENST00000567439ENST00000538853FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000564108ENST00000438132FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000564108ENST00000542263FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000564108ENST00000417362FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000564108ENST00000251143FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000564108ENST00000543152FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000564108ENST00000448695FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3UTRENST00000564108ENST00000544275FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-intronENST00000564108ENST00000538853FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000438132FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000542263FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000417362FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000251143FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000543152FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3CDSENST00000562400ENST00000448695FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-3UTRENST00000562400ENST00000544275FAM192Achr16

57219943

-C16orf62chr16

19663298

+
intron-intronENST00000562400ENST00000538853FAM192Achr16

57219943

-C16orf62chr16

19663298

+

Top

FusionProtFeatures for FAM192A_C16orf62


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM192A

Q9GZU8

C16orf62

Q7Z3J2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAM192A_C16orf62


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAM192A_C16orf62


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM192AELAVL1, ATP13A2, LMNA, CLK3, HSFX1, TRAF2, MOV10, NXF1, CAMTA2, SCNM1, PSME3, PSMA1, CPSF7, RAB40A, RSRP1, RAB40AL, FOXD4L6, PSMB9, MRPS22, EWSR1, KIF3A, BLM, CLCN2, PRKCD, YWHAH, KIFAP3, CREB1, RPL15, RASL10B, CCDC69, IL17RE, TP53TG5, HUS1B, PSMB3, PPM1E, MRPS34, MTNR1BC16orf62CCDC22, CCDC93, COMMD1, BSG, COMMD3, COMMD4, DCUN1D1, TRIM25, NTRK1, COMMD6, VPS29, COMMD2, COMMD10, COMMD8, FAM45A, HDAC11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM192A_C16orf62


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM192A_C16orf62


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource