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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1265

FusionGeneSummary for AIG1_FAM3A

check button Fusion gene summary
Fusion gene informationFusion gene name: AIG1_FAM3A
Fusion gene ID: 1265
HgeneTgene
Gene symbol

AIG1

FAM3A

Gene ID

51390

60343

Gene nameandrogen induced 1family with sequence similarity 3 member A
SynonymsAIG-1|dJ95L4.12.19|DLD|DXS560S|XAP-7
Cytomap

6q24.2

Xq28

Type of geneprotein-codingprotein-coding
Descriptionandrogen-induced gene 1 proteinprotein FAM3Acytokine-like protein 2-19
Modification date2018052920180522
UniProtAcc

Q9NVV5

P98173

Ensembl transtripts involved in fusion geneENST00000357847, ENST00000344492, 
ENST00000275235, ENST00000367598, 
ENST00000494282, ENST00000367596, 
ENST00000434658, ENST00000359889, 
ENST00000369643, ENST00000447601, 
ENST00000369641, ENST00000393572, 
ENST00000492763, 
Fusion gene scores* DoF score6 X 5 X 4=1201 X 1 X 1=1
# samples 71
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: AIG1 [Title/Abstract] AND FAM3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFAM3A

GO:0019732

antifungal humoral response

18212107

TgeneFAM3A

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

18212107

TgeneFAM3A

GO:1905035

negative regulation of antifungal innate immune response

18212107


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ081920AIG1chr6

143661275

+FAM3AchrX

153734552

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000357847ENST00000434658AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-3UTRENST00000357847ENST00000359889AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-3UTRENST00000357847ENST00000369643AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-3UTRENST00000357847ENST00000447601AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-intronENST00000357847ENST00000369641AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-intronENST00000357847ENST00000393572AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-intronENST00000357847ENST00000492763AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-3UTRENST00000344492ENST00000434658AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-3UTRENST00000344492ENST00000359889AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-3UTRENST00000344492ENST00000369643AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-3UTRENST00000344492ENST00000447601AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-intronENST00000344492ENST00000369641AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-intronENST00000344492ENST00000393572AIG1chr6

143661275

+FAM3AchrX

153734552

-
3UTR-intronENST00000344492ENST00000492763AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000275235ENST00000434658AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000275235ENST00000359889AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000275235ENST00000369643AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000275235ENST00000447601AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000275235ENST00000369641AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000275235ENST00000393572AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000275235ENST00000492763AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000367598ENST00000434658AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000367598ENST00000359889AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000367598ENST00000369643AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000367598ENST00000447601AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000367598ENST00000369641AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000367598ENST00000393572AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000367598ENST00000492763AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000494282ENST00000434658AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000494282ENST00000359889AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000494282ENST00000369643AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000494282ENST00000447601AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000494282ENST00000369641AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000494282ENST00000393572AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000494282ENST00000492763AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000367596ENST00000434658AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000367596ENST00000359889AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000367596ENST00000369643AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-3UTRENST00000367596ENST00000447601AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000367596ENST00000369641AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000367596ENST00000393572AIG1chr6

143661275

+FAM3AchrX

153734552

-
intron-intronENST00000367596ENST00000492763AIG1chr6

143661275

+FAM3AchrX

153734552

-

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FusionProtFeatures for AIG1_FAM3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AIG1

Q9NVV5

FAM3A

P98173

May act as a defensin against invading fungalmicroorganisms.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AIG1_FAM3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AIG1_FAM3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AIG1_FAM3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AIG1_FAM3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource