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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12640

FusionGeneSummary for FAM168B_FAM107B

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM168B_FAM107B
Fusion gene ID: 12640
HgeneTgene
Gene symbol

FAM168B

FAM107B

Gene ID

130074

83641

Gene namefamily with sequence similarity 168 member Bfamily with sequence similarity 107 member B
SynonymsMANIC10orf45|HITS
Cytomap

2q21.1

10p13

Type of geneprotein-codingprotein-coding
Descriptionmyelin-associated neurite-outgrowth inhibitorprotein FAM168Bprotein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small protein
Modification date2018051920180519
UniProtAcc

A1KXE4

Q9H098

Ensembl transtripts involved in fusion geneENST00000409185, ENST00000389915, 
ENST00000181796, ENST00000378470, 
ENST00000468747, ENST00000378467, 
ENST00000378465, ENST00000378458, 
ENST00000478076, ENST00000378462, 
ENST00000496330, ENST00000479731, 
ENST00000471815, 
Fusion gene scores* DoF score5 X 7 X 2=709 X 7 X 6=378
# samples 79
** MAII scorelog2(7/70*10)=0log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM168B [Title/Abstract] AND FAM107B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF902150FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000409185ENST00000181796FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000378470FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000468747FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000378467FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000378465FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000378458FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000478076FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000378462FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000496330FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000479731FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000409185ENST00000471815FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000181796FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000378470FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000468747FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000378467FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000378465FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000378458FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000478076FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000378462FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000496330FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000479731FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-
intron-intronENST00000389915ENST00000471815FAM168Bchr2

131809662

+FAM107Bchr10

14613016

-

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FusionProtFeatures for FAM168B_FAM107B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM168B

A1KXE4

FAM107B

Q9H098

Modulates neuronal axonal outgrowth by acting as anegative regulator of CDC42 and STAT3 and a positive regulator ofSTMN2. Positive regulator of CDC27 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM168B_FAM107B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM168B_FAM107B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM168B_FAM107B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM168B_FAM107B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource