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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12624

FusionGeneSummary for FAM168A_MYEOV

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM168A_MYEOV
Fusion gene ID: 12624
HgeneTgene
Gene symbol

FAM168A

MYEOV

Gene ID

23201

26579

Gene namefamily with sequence similarity 168 member Amyeloma overexpressed
SynonymsKIAA0280|TCRP1OCIM
Cytomap

11q13.4

11q13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM168Atongue cancer chemotherapy resistance-associated protein 1myeloma-overexpressed gene proteinmyeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas)oncogene in multiple myeloma
Modification date2018052320180519
UniProtAcc

Q92567

Q96EZ4

Ensembl transtripts involved in fusion geneENST00000064778, ENST00000450446, 
ENST00000356467, 
ENST00000441339, 
ENST00000308946, ENST00000535407, 
ENST00000541137, 
Fusion gene scores* DoF score20 X 4 X 10=80013 X 4 X 7=364
# samples 2314
** MAII scorelog2(23/800*10)=-1.79836613883035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/364*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM168A [Title/Abstract] AND MYEOV [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM168A

GO:1905053

positive regulation of base-excision repair

25260657


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-DA-A95V-06AFAM168Achr11

73308968

-MYEOVchr11

69156278

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000064778ENST00000441339FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-intronENST00000064778ENST00000308946FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-intronENST00000064778ENST00000535407FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-3UTRENST00000064778ENST00000541137FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-intronENST00000450446ENST00000441339FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-intronENST00000450446ENST00000308946FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-intronENST00000450446ENST00000535407FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-3UTRENST00000450446ENST00000541137FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-intronENST00000356467ENST00000441339FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-intronENST00000356467ENST00000308946FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-intronENST00000356467ENST00000535407FAM168Achr11

73308968

-MYEOVchr11

69156278

+
5UTR-3UTRENST00000356467ENST00000541137FAM168Achr11

73308968

-MYEOVchr11

69156278

+

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FusionProtFeatures for FAM168A_MYEOV


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM168A

Q92567

MYEOV

Q96EZ4

In cancer context, protects cells from induced-DNAdamage and apoptosis. Acts, at least in part, throughPI3K/AKT/NFKB signaling pathway and by preventing POLBdegradation. Decreases POLB ubiquitation and stabilizes itsprotein levels. {ECO:0000269|PubMed:21334329,ECO:0000269|PubMed:21603883, ECO:0000269|PubMed:23251525,ECO:0000269|PubMed:25260657}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM168A_MYEOV


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM168A_MYEOV


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM168ABAG3, RBFOX1, DAB1, SNRPC, UBE2V1, SF1, TAX1BP1, DAZAP2, CALCOCO2, TNIP1, RBPMS, R3HDM2, FAM168A, SS18L1, VPS37C, KLHL42, SMAP2, OTUB2, UBASH3B, C1orf94, OTULIN, NAF1, DTX2, PRR20A, MOV10, FBXO6, WWP2, EWSR1, FBXW5, MCM2, TRIM25MYEOVPRTFDC1, CNN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM168A_MYEOV


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM168A_MYEOV


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAM168AC0038356Stomach Neoplasms1CTD_human